{
  "url": "https://dantelabs.com/traits/abnormal-b-cell-physiology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-b-cell-physiology",
    "id": "HP:0005372",
    "name": "Abnormality of B cell physiology",
    "label": "Abnormal B cell physiology",
    "definition": "An abnormality of the physiological functioning of B cells.",
    "synonyms": [
      "Reduced B cell function"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-lymphocyte-physiology",
        "name": "Abnormal lymphocyte physiology",
        "url": "https://dantelabs.com/traits/abnormal-lymphocyte-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-circulating-immunoglobulin-concentration",
        "name": "Abnormal circulating immunoglobulin concentration",
        "genes": 8,
        "url": "https://dantelabs.com/traits/abnormal-circulating-immunoglobulin-concentration"
      },
      {
        "slug": "impaired-ig-class-switch-recombination",
        "name": "Impaired Ig class switch recombination",
        "genes": 4,
        "url": "https://dantelabs.com/traits/impaired-ig-class-switch-recombination"
      },
      {
        "slug": "impaired-memory-b-cell-generation",
        "name": "Impaired memory B cell generation",
        "genes": 2,
        "url": "https://dantelabs.com/traits/impaired-memory-b-cell-generation"
      },
      {
        "slug": "defective-b-cell-activation",
        "name": "Defective B cell activation",
        "genes": 1,
        "url": "https://dantelabs.com/traits/defective-b-cell-activation"
      },
      {
        "slug": "abnormal-immunoglobulin-level-in-body-fluid",
        "name": "Abnormal immunoglobulin level in body fluid",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-immunoglobulin-level-in-body-fluid"
      }
    ],
    "genes": [
      {
        "slug": "jak3",
        "symbol": "JAK3",
        "hgnc": "HGNC:6193",
        "name": "Janus kinase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak3"
      },
      {
        "slug": "pnp",
        "symbol": "PNP",
        "hgnc": "HGNC:7892",
        "name": "purine nucleoside phosphorylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnp"
      }
    ]
  }
}