{
  "url": "https://dantelabs.com/pl/genes/wnt10a",
  "gene": {
    "slug": "wnt10a",
    "symbol": "WNT10A",
    "name": "Wnt family member 10A",
    "hgnc": "HGNC:13829",
    "summary": null,
    "location": "2q35",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000135925",
    "entrezId": 80326,
    "omim": [
      "606268"
    ],
    "uniprot": [
      "Q9GZT5"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "2",
      "start": 218880852,
      "end": 218893928,
      "strand": "+",
      "ensemblTranscript": "ENST00000258411.8",
      "refseqTranscript": "NM_025216.3",
      "ensemblProtein": "ENSP00000258411.3",
      "refseqProtein": "NP_079492.2",
      "exons": [
        {
          "start": 218880852,
          "end": 218881108
        },
        {
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          "end": 218882423
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          "end": 218890363
        },
        {
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          "end": 218893928
        }
      ],
      "cds": {
        "start": 218880996,
        "end": 218893271
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "2",
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      "end": 219764303,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 219387389,
      "genes": [
        {
          "symbol": "SLC11A1",
          "ensemblId": "ENSG00000018280",
          "biotype": "protein_coding",
          "start": 218382006,
          "end": 218396906,
          "strand": "+",
          "slug": "slc11a1"
        },
        {
          "symbol": "CTDSP1",
          "ensemblId": "ENSG00000144579",
          "biotype": "protein_coding",
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          "end": 218405942,
          "strand": "+",
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        {
          "symbol": "VIL1",
          "ensemblId": "ENSG00000127831",
          "biotype": "protein_coding",
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          "end": 218453295,
          "strand": "+",
          "slug": "vil1"
        },
        {
          "symbol": "USP37",
          "ensemblId": "ENSG00000135913",
          "biotype": "protein_coding",
          "start": 218450251,
          "end": 218568768,
          "strand": "-",
          "slug": "usp37"
        },
        {
          "symbol": "CNOT9",
          "ensemblId": "ENSG00000144580",
          "biotype": "protein_coding",
          "start": 218568575,
          "end": 218597080,
          "strand": "+",
          "slug": "cnot9"
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        {
          "symbol": "PLCD4",
          "ensemblId": "ENSG00000115556",
          "biotype": "protein_coding",
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          "end": 218637186,
          "strand": "+",
          "slug": "plcd4"
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        {
          "symbol": "ZNF142",
          "ensemblId": "ENSG00000115568",
          "biotype": "protein_coding",
          "start": 218633329,
          "end": 218659655,
          "strand": "-",
          "slug": "znf142"
        },
        {
          "symbol": "BCS1L",
          "ensemblId": "ENSG00000074582",
          "biotype": "protein_coding",
          "start": 218658764,
          "end": 218668759,
          "strand": "+",
          "slug": "bcs1l"
        },
        {
          "symbol": "RNF25",
          "ensemblId": "ENSG00000163481",
          "biotype": "protein_coding",
          "start": 218662081,
          "end": 218672009,
          "strand": "-",
          "slug": "rnf25"
        },
        {
          "symbol": "STK36",
          "ensemblId": "ENSG00000163482",
          "biotype": "protein_coding",
          "start": 218672027,
          "end": 218702717,
          "strand": "+",
          "slug": "stk36"
        },
        {
          "symbol": "TTLL4",
          "ensemblId": "ENSG00000135912",
          "biotype": "protein_coding",
          "start": 218710773,
          "end": 218759724,
          "strand": "+",
          "slug": "ttll4"
        },
        {
          "symbol": "CYP27A1",
          "ensemblId": "ENSG00000135929",
          "biotype": "protein_coding",
          "start": 218781688,
          "end": 218825335,
          "strand": "+",
          "slug": "cyp27a1"
        },
        {
          "symbol": "PRKAG3",
          "ensemblId": "ENSG00000115592",
          "biotype": "protein_coding",
          "start": 218819050,
          "end": 218832086,
          "strand": "-",
          "slug": "prkag3"
        },
        {
          "symbol": "WNT6",
          "ensemblId": "ENSG00000115596",
          "biotype": "protein_coding",
          "start": 218859795,
          "end": 218874233,
          "strand": "+",
          "slug": "wnt6"
        },
        {
          "symbol": "CDK5R2",
          "ensemblId": "ENSG00000171450",
          "biotype": "protein_coding",
          "start": 218959666,
          "end": 218962155,
          "strand": "+",
          "slug": "cdk5r2"
        },
        {
          "symbol": "FEV",
          "ensemblId": "ENSG00000163497",
          "biotype": "protein_coding",
          "start": 218981087,
          "end": 218985566,
          "strand": "-",
          "slug": "fev"
        },
        {
          "symbol": "CRYBA2",
          "ensemblId": "ENSG00000163499",
          "biotype": "protein_coding",
          "start": 218990189,
          "end": 218994270,
          "strand": "-",
          "slug": "cryba2"
        },
        {
          "symbol": "CFAP65",
          "ensemblId": "ENSG00000181378",
          "biotype": "protein_coding",
          "start": 219002846,
          "end": 219041527,
          "strand": "-",
          "slug": "cfap65"
        },
        {
          "symbol": "IHH",
          "ensemblId": "ENSG00000163501",
          "biotype": "protein_coding",
          "start": 219054424,
          "end": 219061064,
          "strand": "-",
          "slug": "ihh"
        },
        {
          "symbol": "NHEJ1",
          "ensemblId": "ENSG00000187736",
          "biotype": "protein_coding",
          "start": 219069355,
          "end": 219160869,
          "strand": "-",
          "slug": "nhej1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000280537",
          "biotype": "protein_coding",
          "start": 219075329,
          "end": 219170827,
          "strand": "-"
        },
        {
          "symbol": "SLC23A3",
          "ensemblId": "ENSG00000213901",
          "biotype": "protein_coding",
          "start": 219161465,
          "end": 219170095,
          "strand": "-",
          "slug": "slc23a3"
        },
        {
          "symbol": "CNPPD1",
          "ensemblId": "ENSG00000115649",
          "biotype": "protein_coding",
          "start": 219170704,
          "end": 219182664,
          "strand": "-",
          "slug": "cnppd1"
        },
        {
          "symbol": "RETREG2",
          "ensemblId": "ENSG00000144567",
          "biotype": "protein_coding",
          "start": 219176225,
          "end": 219185917,
          "strand": "+",
          "slug": "retreg2"
        },
        {
          "symbol": "ZFAND2B",
          "ensemblId": "ENSG00000158552",
          "biotype": "protein_coding",
          "start": 219195237,
          "end": 219209651,
          "strand": "+",
          "slug": "zfand2b"
        },
        {
          "symbol": "ABCB6",
          "ensemblId": "ENSG00000115657",
          "biotype": "protein_coding",
          "start": 219209765,
          "end": 219219012,
          "strand": "-",
          "slug": "abcb6"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000284820",
          "biotype": "protein_coding",
          "start": 219209772,
          "end": 219222738,
          "strand": "-"
        },
        {
          "symbol": "ATG9A",
          "ensemblId": "ENSG00000198925",
          "biotype": "protein_coding",
          "start": 219219380,
          "end": 219230383,
          "strand": "-",
          "slug": "atg9a"
        },
        {
          "symbol": "ANKZF1",
          "ensemblId": "ENSG00000163516",
          "biotype": "protein_coding",
          "start": 219229769,
          "end": 219236679,
          "strand": "+",
          "slug": "ankzf1"
        },
        {
          "symbol": "GLB1L",
          "ensemblId": "ENSG00000163521",
          "biotype": "protein_coding",
          "start": 219236598,
          "end": 219245478,
          "strand": "-",
          "slug": "glb1l"
        },
        {
          "symbol": "STK16",
          "ensemblId": "ENSG00000115661",
          "biotype": "protein_coding",
          "start": 219245212,
          "end": 219250339,
          "strand": "+",
          "slug": "stk16"
        },
        {
          "symbol": "TUBA4A",
          "ensemblId": "ENSG00000127824",
          "biotype": "protein_coding",
          "start": 219249710,
          "end": 219277902,
          "strand": "-",
          "slug": "tuba4a"
        },
        {
          "symbol": "TUBA4B",
          "ensemblId": "ENSG00000243910",
          "biotype": "protein_coding",
          "start": 219253243,
          "end": 219272197,
          "strand": "+",
          "slug": "tuba4b"
        },
        {
          "symbol": "DNAJB2",
          "ensemblId": "ENSG00000135924",
          "biotype": "protein_coding",
          "start": 219279308,
          "end": 219286900,
          "strand": "+",
          "slug": "dnajb2"
        },
        {
          "symbol": "PTPRN",
          "ensemblId": "ENSG00000054356",
          "biotype": "protein_coding",
          "start": 219289623,
          "end": 219309648,
          "strand": "-",
          "slug": "ptprn"
        },
        {
          "symbol": "RESP18",
          "ensemblId": "ENSG00000182698",
          "biotype": "protein_coding",
          "start": 219327407,
          "end": 219335552,
          "strand": "-",
          "slug": "resp18"
        },
        {
          "symbol": "DNPEP",
          "ensemblId": "ENSG00000123992",
          "biotype": "protein_coding",
          "start": 219360090,
          "end": 219400022,
          "strand": "-",
          "slug": "dnpep"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "ectodermal-dysplasias",
        "name": "Dysplazje ektodermalne",
        "diseases": [
          {
            "mondoId": "MONDO:0100358",
            "name": "Dysplazja ektodermalna związana z genem WNT10A",
            "genes": 1,
            "inheritance": null,
            "description": "Zaburzenie związane z genem WNT10A, od izolowanego braku zębów po dysplazję odontoonychodermalną ze zmianami paznokci i skóry.",
            "management": "Wczesna ocena stomatologiczna pomaga zaplanować leczenie brakujących zębów.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Illumina",
                "Labcorp Genetics (formerly Invitae)",
                "Natera",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/pl/conditions/ectodermal-dysplasias"
      },
      {
        "slug": "hereditary-palmoplantar-keratodermas",
        "name": "Dziedziczne keratodermie dłoni i stóp oraz wrodzona pachyonychia",
        "diseases": [
          {
            "mondoId": "MONDO:0019272",
            "name": "Dziedziczna keratodermia dłoni i stóp",
            "genes": 35,
            "inheritance": null,
            "description": "Dziedziczne pogrubienie dłoni i stóp, w tym wrodzona pachyonychia, choroba Meledy (mal de Meleda), keratodermie typu Nagashimy i bothnijska, zespół keratitis-ichthyosis-deafness oraz zespoły Papillon-Lefèvre i Haim-Munk związane z genem CTSC.",
            "management": "Rozpoznanie pomaga w doborze pielęgnacji stóp i leczeniu bólu; w postaciach związanych z CTSC wczesne leczenie stomatologiczne chroni zęby, a w postaciach związanych z GJB2 zaleca się badanie słuchu.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/pl/conditions/hereditary-palmoplantar-keratodermas"
      },
      {
        "slug": "hypodontia-and-anodontia",
        "name": "Hipodoncja i anodoncja",
        "diseases": [
          {
            "mondoId": "MONDO:0005486",
            "name": "Agenezja zębów (hipodoncja)",
            "genes": 7,
            "inheritance": null,
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/pl/conditions/hypodontia-and-anodontia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-fingernail-morphology",
        "name": "Abnormal fingernails",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-fingernail-morphology"
      },
      {
        "slug": "abnormal-primary-tooth-morphology",
        "name": "Abnormality of baby teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-primary-tooth-morphology"
      },
      {
        "slug": "abnormal-canine-tooth-morphology",
        "name": "Abnormality of canine",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-canine-tooth-morphology"
      },
      {
        "slug": "abnormal-dental-morphology",
        "name": "Abnormality of dental shape",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-dental-morphology"
      },
      {
        "slug": "abnormal-primary-molar-morphology",
        "name": "Abnormality of shape of baby molar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-primary-molar-morphology"
      },
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "systems": [],
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      },
      {
        "slug": "abnormal-hair-morphology",
        "name": "Abnormality of the hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-hair-morphology"
      },
      {
        "slug": "abnormal-toenail-morphology",
        "name": "Abnormality of the toenail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-toenail-morphology"
      },
      {
        "slug": "agenesis-of-permanent-teeth",
        "name": "Absence of adult teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/agenesis-of-permanent-teeth"
      },
      {
        "slug": "agenesis-of-mandibular-premolar",
        "name": "Absence of lower premolar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/agenesis-of-mandibular-premolar"
      },
      {
        "slug": "agenesis-of-premolar",
        "name": "Absence of premolar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-premolar"
      },
      {
        "slug": "agenesis-of-first-permanent-molar-tooth",
        "name": "Absence of six year molar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-first-permanent-molar-tooth"
      },
      {
        "slug": "agenesis-of-maxillary-lateral-incisor",
        "name": "Absence of upper lateral incisor",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-maxillary-lateral-incisor"
      },
      {
        "slug": "agenesis-of-central-incisor",
        "name": "Absent central incisor",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-central-incisor"
      },
      {
        "slug": "anonychia",
        "name": "Absent nails",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/anonychia"
      },
      {
        "slug": "apocrine-hidrocystoma",
        "name": "Apocrine hidrocystoma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/apocrine-hidrocystoma"
      },
      {
        "slug": "nail-dysplasia",
        "name": "Atypical nail growth",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/nail-dysplasia"
      },
      {
        "slug": "dental-malocclusion",
        "name": "Bad bite",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dental-malocclusion"
      },
      {
        "slug": "basal-cell-carcinoma",
        "name": "Basal cell carcinoma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/basal-cell-carcinoma"
      },
      {
        "slug": "bird-like-facies",
        "name": "Bird-like facial appearance",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bird-like-facies"
      },
      {
        "slug": "impaired-mastication",
        "name": "Chewing difficulties",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/impaired-mastication"
      },
      {
        "slug": "keratosis-pilaris",
        "name": "Chicken skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/keratosis-pilaris"
      },
      {
        "slug": "orofacial-cleft",
        "name": "Cleft of the mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/orofacial-cleft"
      },
      {
        "slug": "conical-incisor",
        "name": "Cone shaped front tooth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/conical-incisor"
      },
      {
        "slug": "hypohidrosis",
        "name": "Decreased ability to sweat",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypohidrosis"
      },
      {
        "slug": "short-dental-root",
        "name": "Decreased length of dental roots",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-dental-root"
      },
      {
        "slug": "tooth-agenesis",
        "name": "Decreased number of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/tooth-agenesis"
      },
      {
        "slug": "hypoplasia-of-teeth",
        "name": "Decreased size of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypoplasia-of-teeth"
      },
      {
        "slug": "microdontia",
        "name": "Decreased size of tooth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/microdontia"
      },
      {
        "slug": "delayed-eruption-of-permanent-teeth",
        "name": "Delayed eruption of permanent teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-eruption-of-permanent-teeth"
      },
      {
        "slug": "delayed-eruption-of-teeth",
        "name": "Delayed eruption of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-eruption-of-teeth"
      },
      {
        "slug": "onycholysis",
        "name": "Detachment of nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/onycholysis"
      },
      {
        "slug": "dry-hair",
        "name": "Dry hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/dry-hair"
      },
      {
        "slug": "dry-skin",
        "name": "Dry skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dry-skin"
      },
      {
        "slug": "premature-loss-of-primary-teeth",
        "name": "Early loss of baby teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/premature-loss-of-primary-teeth"
      },
      {
        "slug": "ectodermal-dysplasia",
        "name": "Ectodermal dysplasia",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/ectodermal-dysplasia"
      },
      {
        "slug": "hyperhidrosis",
        "name": "Excessive sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperhidrosis"
      },
      {
        "slug": "palmoplantar-hyperhidrosis",
        "name": "Excessive sweating of palms and soles",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/palmoplantar-hyperhidrosis"
      },
      {
        "slug": "photophobia",
        "name": "Extreme sensitivity of the eyes to light",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/photophobia"
      },
      {
        "slug": "facial-telangiectasia",
        "name": "Facial telangiectasia",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/facial-telangiectasia"
      },
      {
        "slug": "hypodontia",
        "name": "Failure of development of between one and six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypodontia"
      },
      {
        "slug": "oligodontia",
        "name": "Failure of development of more than six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oligodontia"
      },
      {
        "slug": "fine-hair",
        "name": "Fine hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/fine-hair"
      },
      {
        "slug": "follicular-hyperkeratosis",
        "name": "Follicular hyperkeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/follicular-hyperkeratosis"
      },
      {
        "slug": "ridged-nail",
        "name": "Grooved nails",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ridged-nail"
      },
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/alopecia"
      },
      {
        "slug": "hypergranulosis",
        "name": "Hypergranulosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/hypergranulosis"
      },
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      },
      {
        "slug": "multiple-eyelid-margin-cysts",
        "name": "Multiple eyelid margin cysts",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/multiple-eyelid-margin-cysts"
      },
      {
        "slug": "narrow-nail",
        "name": "Narrow nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/narrow-nail"
      },
      {
        "slug": "orthokeratosis",
        "name": "Orthokeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/orthokeratosis"
      },
      {
        "slug": "eclabion",
        "name": "Outward turned lips",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/eclabion"
      },
      {
        "slug": "ovarian-neoplasm",
        "name": "Ovarian cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ovarian-neoplasm"
      },
      {
        "slug": "palmar-hyperkeratosis",
        "name": "Palmar hyperkeratosis",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/palmar-hyperkeratosis"
      },
      {
        "slug": "palmoplantar-erythema",
        "name": "Palmoplantar erythema",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/palmoplantar-erythema"
      },
      {
        "slug": "peg-shaped-maxillary-lateral-incisors",
        "name": "Peg-shaped maxillary lateral incisors",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/peg-shaped-maxillary-lateral-incisors"
      },
      {
        "slug": "plantar-hyperkeratosis",
        "name": "Plantar hyperkeratosis",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/plantar-hyperkeratosis"
      },
      {
        "slug": "dystrophic-fingernails",
        "name": "Poor fingernail formation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dystrophic-fingernails"
      },
      {
        "slug": "nail-dystrophy",
        "name": "Poor nail formation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/nail-dystrophy"
      },
      {
        "slug": "dystrophic-toenail",
        "name": "Poor toenail formation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dystrophic-toenail"
      },
      {
        "slug": "poroma",
        "name": "Poroma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/poroma"
      },
      {
        "slug": "erythema",
        "name": "Redness of skin or mucous membrane",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/erythema"
      },
      {
        "slug": "short-eyelashes",
        "name": "Short eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-eyelashes"
      },
      {
        "slug": "short-face",
        "name": "Short face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-face"
      },
      {
        "slug": "short-nail",
        "name": "Short nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-nail"
      },
      {
        "slug": "small-nail",
        "name": "Small nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/small-nail"
      },
      {
        "slug": "smooth-tongue",
        "name": "Smooth tongue",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/smooth-tongue"
      },
      {
        "slug": "sparse-body-hair",
        "name": "Sparse body hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-body-hair"
      },
      {
        "slug": "sparse-eyebrow",
        "name": "Sparse eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sparse-eyebrow"
      },
      {
        "slug": "sparse-hair",
        "name": "Sparse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-hair"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-eyebrow",
        "name": "Sparse or absent eyebrows",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-eyebrow"
      },
      {
        "slug": "sparse-scalp-hair",
        "name": "Sparse scalp hair",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sparse-scalp-hair"
      },
      {
        "slug": "squamous-cell-carcinoma",
        "name": "Squamous cell carcinoma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/squamous-cell-carcinoma"
      },
      {
        "slug": "taurodontia",
        "name": "Taurodontia",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/taurodontia"
      },
      {
        "slug": "palmoplantar-keratoderma",
        "name": "Thickening of palms and soles",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/palmoplantar-keratoderma"
      },
      {
        "slug": "palmoplantar-hyperkeratosis",
        "name": "Thickening of the outer layer of the skin of the palms and soles",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/palmoplantar-hyperkeratosis"
      },
      {
        "slug": "epidermal-acanthosis",
        "name": "Thickening of upper layer of skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/epidermal-acanthosis"
      },
      {
        "slug": "enamel-hypoplasia",
        "name": "Thin dental enamel",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/enamel-hypoplasia"
      },
      {
        "slug": "thin-nail",
        "name": "Thin nail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thin-nail"
      },
      {
        "slug": "thin-skin",
        "name": "Thin skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thin-skin"
      },
      {
        "slug": "widely-spaced-primary-teeth",
        "name": "Wide gaps between baby teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/widely-spaced-primary-teeth"
      },
      {
        "slug": "widely-spaced-teeth",
        "name": "Widely spaced teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/widely-spaced-teeth"
      }
    ],
    "related": [
      {
        "slug": "aagab",
        "symbol": "AAGAB",
        "name": "alpha and gamma adaptin binding protein",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/aagab"
      },
      {
        "slug": "ap1b1",
        "symbol": "AP1B1",
        "name": "adaptor related protein complex 1 subunit beta 1",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/ap1b1"
      },
      {
        "slug": "aqp5",
        "symbol": "AQP5",
        "name": "aquaporin 5",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/aqp5"
      },
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "name": "cathepsin C",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/ctsc"
      },
      {
        "slug": "dsg1",
        "symbol": "DSG1",
        "name": "desmoglein 1",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/dsg1"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "name": "desmoplakin",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/dsp"
      },
      {
        "slug": "eda",
        "symbol": "EDA",
        "name": "ectodysplasin A",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/eda"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "name": "gap junction protein alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/gja1"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "name": "gap junction protein beta 2",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/gjb2"
      },
      {
        "slug": "gjb3",
        "symbol": "GJB3",
        "name": "gap junction protein beta 3",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/gjb3"
      },
      {
        "slug": "gjb4",
        "symbol": "GJB4",
        "name": "gap junction protein beta 4",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/gjb4"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "name": "gap junction protein beta 6",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/gjb6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}