{
  "url": "https://dantelabs.com/pl/genes/slc26a5",
  "gene": {
    "slug": "slc26a5",
    "symbol": "SLC26A5",
    "name": "solute carrier family 26 member 5",
    "hgnc": "HGNC:9359",
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    "locusType": "gene with protein product",
    "aliases": [
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      "PRESTIN"
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    "previousSymbols": [
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    "entrezId": 375611,
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      "build": "GRCh37",
      "release": "87",
      "chrom": "7",
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      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
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      "genes": [
        {
          "symbol": "FBXL13",
          "ensemblId": "ENSG00000161040",
          "biotype": "protein_coding",
          "start": 102811020,
          "end": 103075400,
          "strand": "-",
          "slug": "fbxl13"
        },
        {
          "symbol": "LRRC17",
          "ensemblId": "ENSG00000128606",
          "biotype": "protein_coding",
          "start": 102912941,
          "end": 102945111,
          "strand": "+",
          "slug": "lrrc17"
        },
        {
          "symbol": "ARMC10",
          "ensemblId": "ENSG00000170632",
          "biotype": "protein_coding",
          "start": 103074625,
          "end": 103103945,
          "strand": "+",
          "slug": "armc10"
        },
        {
          "symbol": "NAPEPLD",
          "ensemblId": "ENSG00000161048",
          "biotype": "protein_coding",
          "start": 103099776,
          "end": 103151172,
          "strand": "-",
          "slug": "napepld"
        },
        {
          "symbol": "PMPCB",
          "ensemblId": "ENSG00000105819",
          "biotype": "protein_coding",
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          "strand": "+",
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        {
          "symbol": "DNAJC2",
          "ensemblId": "ENSG00000105821",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "dnajc2"
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        {
          "symbol": "PSMC2",
          "ensemblId": "ENSG00000161057",
          "biotype": "protein_coding",
          "start": 103328570,
          "end": 103370346,
          "strand": "+",
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        },
        {
          "symbol": "RELN",
          "ensemblId": "ENSG00000189056",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "reln"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Utrata słuchu i głuchota",
        "diseases": [
          {
            "mondoId": "MONDO:0019497",
            "name": "Niezespołowa genetyczna utrata słuchu",
            "genes": 97,
            "inheritance": null,
            "description": "Dziedziczna utrata słuchu bez innych objawów medycznych, obejmująca częste recesywne postacie wywoływane przez GJB2, OTOF, SLC26A4, STRC i wiele innych genów, a także postacie dominujące, sprzężone z chromosomem X oraz mitochondrialne.",
            "management": "Znajomość genetycznej przyczyny może pomóc w wyborze wsparcia słuchowego i decyzji dotyczących implantu ślimakowego, kwalifikacji do badań terapii genowych (na przykład w przypadku OTOF) oraz poradnictwa rodzinnego.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/pl/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/actg1"
      },
      {
        "slug": "afg2b",
        "symbol": "AFG2B",
        "name": "AAA ATPase AFG2B",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/afg2b"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/aifm1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/atp2b2"
      },
      {
        "slug": "cabp2",
        "symbol": "CABP2",
        "name": "calcium binding protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/cabp2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/cd164"
      },
      {
        "slug": "cdc14a",
        "symbol": "CDC14A",
        "name": "cell division cycle 14A",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/cdc14a"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "name": "cadherin related 23",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/cdh23"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/ceacam16"
      },
      {
        "slug": "cib2",
        "symbol": "CIB2",
        "name": "calcium and integrin binding family member 2",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/cib2"
      },
      {
        "slug": "cldn14",
        "symbol": "CLDN14",
        "name": "claudin 14",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/cldn14"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}