{
  "url": "https://dantelabs.com/pl/genes/scnn1a",
  "gene": {
    "slug": "scnn1a",
    "symbol": "SCNN1A",
    "name": "sodium channel epithelial 1 subunit alpha",
    "hgnc": "HGNC:10599",
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    "location": "12p13.31",
    "locusType": "gene with protein product",
    "aliases": [
      "ENaCalpha"
    ],
    "previousSymbols": [
      "SCNN1"
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    "ensemblId": "ENSG00000111319",
    "entrezId": 6337,
    "omim": [
      "600228"
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    "uniprot": [
      "P37088"
    ],
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      "refseqTranscript": "NM_001038.6",
      "ensemblProtein": "ENSP00000228916.2",
      "refseqProtein": "NP_001029.1",
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      ],
      "cds": {
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    },
    "grch37": {
      "build": "GRCh37",
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      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 6861204,
      "genes": [
        {
          "symbol": "ANO2",
          "ensemblId": "ENSG00000047617",
          "biotype": "protein_coding",
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          "end": 5946232,
          "strand": "-",
          "slug": "ano2"
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        {
          "symbol": "VWF",
          "ensemblId": "ENSG00000110799",
          "biotype": "protein_coding",
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          "end": 6124770,
          "strand": "-",
          "slug": "vwf"
        },
        {
          "symbol": "CD9",
          "ensemblId": "ENSG00000010278",
          "biotype": "protein_coding",
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          "end": 6238271,
          "strand": "+",
          "slug": "cd9"
        },
        {
          "symbol": "PLEKHG6",
          "ensemblId": "ENSG00000008323",
          "biotype": "protein_coding",
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          "end": 6328934,
          "strand": "+",
          "slug": "plekhg6"
        },
        {
          "symbol": "TNFRSF1A",
          "ensemblId": "ENSG00000067182",
          "biotype": "protein_coding",
          "start": 6328757,
          "end": 6342114,
          "strand": "-",
          "slug": "tnfrsf1a"
        },
        {
          "symbol": "LTBR",
          "ensemblId": "ENSG00000111321",
          "biotype": "protein_coding",
          "start": 6375045,
          "end": 6391571,
          "strand": "+",
          "slug": "ltbr"
        },
        {
          "symbol": "CD27",
          "ensemblId": "ENSG00000139193",
          "biotype": "protein_coding",
          "start": 6444933,
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          "strand": "+",
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        },
        {
          "symbol": "TAPBPL",
          "ensemblId": "ENSG00000139192",
          "biotype": "protein_coding",
          "start": 6451690,
          "end": 6466517,
          "strand": "+",
          "slug": "tapbpl"
        },
        {
          "symbol": "VAMP1",
          "ensemblId": "ENSG00000139190",
          "biotype": "protein_coding",
          "start": 6462237,
          "end": 6470948,
          "strand": "-",
          "slug": "vamp1"
        },
        {
          "symbol": "MRPL51",
          "ensemblId": "ENSG00000111639",
          "biotype": "protein_coding",
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          "end": 6493856,
          "strand": "-",
          "slug": "mrpl51"
        },
        {
          "symbol": "NCAPD2",
          "ensemblId": "ENSG00000010292",
          "biotype": "protein_coding",
          "start": 6493356,
          "end": 6531970,
          "strand": "+",
          "slug": "ncapd2"
        },
        {
          "symbol": "GAPDH",
          "ensemblId": "ENSG00000111640",
          "biotype": "protein_coding",
          "start": 6534012,
          "end": 6538930,
          "strand": "+",
          "slug": "gapdh"
        },
        {
          "symbol": "IFFO1",
          "ensemblId": "ENSG00000010295",
          "biotype": "protein_coding",
          "start": 6538961,
          "end": 6556102,
          "strand": "-",
          "slug": "iffo1"
        },
        {
          "symbol": "NOP2",
          "ensemblId": "ENSG00000111641",
          "biotype": "protein_coding",
          "start": 6556863,
          "end": 6568691,
          "strand": "-",
          "slug": "nop2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285238",
          "biotype": "protein_coding",
          "start": 6556886,
          "end": 6607367,
          "strand": "-"
        },
        {
          "symbol": "CHD4",
          "ensemblId": "ENSG00000111642",
          "biotype": "protein_coding",
          "start": 6570081,
          "end": 6614982,
          "strand": "-",
          "slug": "chd4"
        },
        {
          "symbol": "LPAR5",
          "ensemblId": "ENSG00000184574",
          "biotype": "protein_coding",
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          "end": 6636444,
          "strand": "-",
          "slug": "lpar5"
        },
        {
          "symbol": "ACRBP",
          "ensemblId": "ENSG00000111644",
          "biotype": "protein_coding",
          "start": 6638075,
          "end": 6647441,
          "strand": "-",
          "slug": "acrbp"
        },
        {
          "symbol": "ING4",
          "ensemblId": "ENSG00000111653",
          "biotype": "protein_coding",
          "start": 6650282,
          "end": 6663180,
          "strand": "-",
          "slug": "ing4"
        },
        {
          "symbol": "ZNF384",
          "ensemblId": "ENSG00000126746",
          "biotype": "protein_coding",
          "start": 6665037,
          "end": 6689572,
          "strand": "-",
          "slug": "znf384"
        },
        {
          "symbol": "PIANP",
          "ensemblId": "ENSG00000139200",
          "biotype": "protein_coding",
          "start": 6693791,
          "end": 6700859,
          "strand": "-",
          "slug": "pianp"
        },
        {
          "symbol": "COPS7A",
          "ensemblId": "ENSG00000111652",
          "biotype": "protein_coding",
          "start": 6724014,
          "end": 6732462,
          "strand": "+",
          "slug": "cops7a"
        },
        {
          "symbol": "MLF2",
          "ensemblId": "ENSG00000089693",
          "biotype": "protein_coding",
          "start": 6747986,
          "end": 6768932,
          "strand": "-",
          "slug": "mlf2"
        },
        {
          "symbol": "PTMS",
          "ensemblId": "ENSG00000159335",
          "biotype": "protein_coding",
          "start": 6765516,
          "end": 6770952,
          "strand": "+",
          "slug": "ptms"
        },
        {
          "symbol": "LAG3",
          "ensemblId": "ENSG00000089692",
          "biotype": "protein_coding",
          "start": 6772360,
          "end": 6778455,
          "strand": "+",
          "slug": "lag3"
        },
        {
          "symbol": "CD4",
          "ensemblId": "ENSG00000010610",
          "biotype": "protein_coding",
          "start": 6786858,
          "end": 6820807,
          "strand": "+",
          "slug": "cd4"
        },
        {
          "symbol": "GPR162",
          "ensemblId": "ENSG00000250510",
          "biotype": "protein_coding",
          "start": 6821624,
          "end": 6829972,
          "strand": "+",
          "slug": "gpr162"
        },
        {
          "symbol": "P3H3",
          "ensemblId": "ENSG00000110811",
          "biotype": "protein_coding",
          "start": 6828220,
          "end": 6839867,
          "strand": "+",
          "slug": "p3h3"
        },
        {
          "symbol": "GNB3",
          "ensemblId": "ENSG00000111664",
          "biotype": "protein_coding",
          "start": 6839954,
          "end": 6847393,
          "strand": "+",
          "slug": "gnb3"
        },
        {
          "symbol": "CDCA3",
          "ensemblId": "ENSG00000111665",
          "biotype": "protein_coding",
          "start": 6844723,
          "end": 6852353,
          "strand": "-",
          "slug": "cdca3"
        },
        {
          "symbol": "USP5",
          "ensemblId": "ENSG00000111667",
          "biotype": "protein_coding",
          "start": 6852098,
          "end": 6866632,
          "strand": "+",
          "slug": "usp5"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "monogenic-hypertension-mineralocorticoid-disorders",
        "name": "Monogenicznie uwarunkowane nadciśnienie i zaburzenia mineralokortykoidowe",
        "diseases": [
          {
            "mondoId": "MONDO:0019161",
            "name": "Pseudohipoaldosteronizm typu 1",
            "genes": 4,
            "inheritance": null,
            "description": "Schorzenie z utratą soli, w którym organizm nie reaguje na aldosteron, wywołane zmianami w genie NR3C2 (łagodniejsza postać ograniczona do nerek) lub w genach kanałów sodowych SCNN1 (cięższa postać wieloukładowa).",
            "management": "Znajomość tego schorzenia wspiera wczesne suplementowanie soli oraz monitorowanie poziomu potasu w niemowlęctwie.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "Laboratory for Molecular Medicine",
                "PanelApp Australia"
              ],
              "clingen": "Strong",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/pl/conditions/monogenic-hypertension-mineralocorticoid-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-circulating-aldosterone-concentration",
        "name": "Abnormal circulating aldosterone",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-aldosterone-concentration"
      },
      {
        "slug": "arrhythmia",
        "name": "Abnormal heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/arrhythmia"
      },
      {
        "slug": "acute-infectious-pneumonia",
        "name": "Acute infectious pneumonia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/acute-infectious-pneumonia"
      },
      {
        "slug": "atopic-dermatitis",
        "name": "Baby eczema",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atopic-dermatitis"
      },
      {
        "slug": "halitosis",
        "name": "Bad breath",
        "systems": [
          "abnormality-of-head-or-neck",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/halitosis"
      },
      {
        "slug": "osteomyelitis",
        "name": "Bone infection",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/osteomyelitis"
      },
      {
        "slug": "dyspnea",
        "name": "Breathing difficulty",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dyspnea"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "chronic-bronchitis",
        "name": "Chronic bronchitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/chronic-bronchitis"
      },
      {
        "slug": "clubbing",
        "name": "Clubbing of fingers and toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/clubbing"
      },
      {
        "slug": "complete-right-bundle-branch-block",
        "name": "Complete right bundle branch block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/complete-right-bundle-branch-block"
      },
      {
        "slug": "constipation",
        "name": "Constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/constipation"
      },
      {
        "slug": "cough",
        "name": "Cough",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cough"
      },
      {
        "slug": "hemoptysis",
        "name": "Coughing up blood",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hemoptysis"
      },
      {
        "slug": "crackles",
        "name": "Crackles",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/crackles"
      },
      {
        "slug": "decreased-circulating-renin-concentration",
        "name": "Decreased circulating renin concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-renin-concentration"
      },
      {
        "slug": "dehydration",
        "name": "Dehydration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dehydration"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "cerebral-ischemia",
        "name": "Disruption of blood oxygen supply to brain",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cerebral-ischemia"
      },
      {
        "slug": "increased-circulating-renin-concentration",
        "name": "Elevated blood renin level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-renin-concentration"
      },
      {
        "slug": "tachycardia",
        "name": "Elevated heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tachycardia"
      },
      {
        "slug": "increased-circulating-aldosterone-concentration",
        "name": "Elevated plasma aldosterone",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-circulating-aldosterone-concentration"
      },
      {
        "slug": "elevated-sweat-chloride",
        "name": "Elevated sweat chloride",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-sweat-chloride"
      },
      {
        "slug": "emphysema",
        "name": "Emphysema",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/emphysema"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "failure-to-thrive-in-infancy",
        "name": "Faltering weight in infancy",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/failure-to-thrive-in-infancy"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "feeding-difficulties-in-infancy",
        "name": "Feeding difficulties in infancy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/feeding-difficulties-in-infancy"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "first-degree-atrioventricular-block",
        "name": "First degree atrioventricular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/first-degree-atrioventricular-block"
      },
      {
        "slug": "abnormal-respiratory-system-physiology",
        "name": "Functional respiratory abnormality",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-respiratory-system-physiology"
      },
      {
        "slug": "cholelithiasis",
        "name": "Gallstones",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cholelithiasis"
      },
      {
        "slug": "glucocortocoid-insensitive-primary-hyperaldosteronism",
        "name": "Glucocortocoid-insensitive primary hyperaldosteronism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/glucocortocoid-insensitive-primary-hyperaldosteronism"
      },
      {
        "slug": "myocardial-infarction",
        "name": "Heart attack",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myocardial-infarction"
      },
      {
        "slug": "cardiac-arrest",
        "name": "Heart stops beating",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cardiac-arrest"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "hyperactive-renin-angiotensin-system",
        "name": "Hyperactive renin-angiotensin system",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/hyperactive-renin-angiotensin-system"
      },
      {
        "slug": "hypovolemic-shock",
        "name": "Hypovolemic shock",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypovolemic-shock"
      },
      {
        "slug": "hyperkalemia",
        "name": "Increased circulating potassium concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperkalemia"
      },
      {
        "slug": "nephropathy",
        "name": "Kidney damage",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nephropathy"
      },
      {
        "slug": "renal-salt-wasting",
        "name": "Loss of salt in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-salt-wasting"
      },
      {
        "slug": "decreased-circulating-aldosterone-concentration",
        "name": "Low blood aldosterone level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-aldosterone-concentration"
      },
      {
        "slug": "hypokalemia",
        "name": "Low blood potassium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypokalemia"
      },
      {
        "slug": "hypotension",
        "name": "Low blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypotension"
      },
      {
        "slug": "hyponatremia",
        "name": "Low blood sodium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyponatremia"
      },
      {
        "slug": "metabolic-acidosis",
        "name": "Metabolic acidosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/metabolic-acidosis"
      },
      {
        "slug": "metabolic-alkalosis",
        "name": "Metabolic alkalosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/metabolic-alkalosis"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      },
      {
        "slug": "paroxysmal-ventricular-tachycardia",
        "name": "Paroxysmal ventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/paroxysmal-ventricular-tachycardia"
      },
      {
        "slug": "bronchiectasis",
        "name": "Permanent enlargement of the airways of the lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bronchiectasis"
      },
      {
        "slug": "pustule",
        "name": "Pimple",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pustule"
      },
      {
        "slug": "proportionate-short-stature",
        "name": "Proportionate short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/proportionate-short-stature"
      },
      {
        "slug": "pseudohypoaldosteronism",
        "name": "Pseudohypoaldosteronism",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/pseudohypoaldosteronism"
      },
      {
        "slug": "recurrent-bronchiolitis",
        "name": "Recurrent bronchiolitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-bronchiolitis"
      },
      {
        "slug": "recurrent-lower-respiratory-tract-infections",
        "name": "Recurrent chest infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-lower-respiratory-tract-infections"
      },
      {
        "slug": "recurrent-haemophilus-influenzae-infection",
        "name": "Recurrent Haemophilus influenzae infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-haemophilus-influenzae-infection"
      },
      {
        "slug": "recurrent-tonsillitis",
        "name": "Recurrent inflammation of tonsils",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-tonsillitis"
      },
      {
        "slug": "recurrent-respiratory-infections",
        "name": "Recurrent respiratory infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/recurrent-respiratory-infections"
      },
      {
        "slug": "recurrent-upper-and-lower-respiratory-tract-infections",
        "name": "Recurrent upper and lower respiratory tract infections",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-upper-and-lower-respiratory-tract-infections"
      },
      {
        "slug": "reduced-fev1-fvc-ratio",
        "name": "Reduced FEV1/FVC ratio",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/reduced-fev1-fvc-ratio"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "respiratory-tract-infection",
        "name": "Respiratory tract infection",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/respiratory-tract-infection"
      },
      {
        "slug": "sick-sinus-syndrome",
        "name": "Sick sinus syndrome",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sick-sinus-syndrome"
      },
      {
        "slug": "st-segment-elevation",
        "name": "ST segment elevation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/st-segment-elevation"
      },
      {
        "slug": "supraventricular-tachycardia",
        "name": "Supraventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/supraventricular-tachycardia"
      },
      {
        "slug": "trifascicular-block",
        "name": "Trifascicular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/trifascicular-block"
      },
      {
        "slug": "ventricular-arrhythmia",
        "name": "Ventricular arrhythmia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/ventricular-arrhythmia"
      },
      {
        "slug": "ventricular-fibrillation",
        "name": "Ventricular fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventricular-fibrillation"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vomiting"
      },
      {
        "slug": "cachexia",
        "name": "Wasting syndrome",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cachexia"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/weight-loss"
      },
      {
        "slug": "productive-cough",
        "name": "Wet cough",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/productive-cough"
      },
      {
        "slug": "wheezing",
        "name": "Wheezing",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/wheezing"
      }
    ],
    "related": [
      {
        "slug": "nr3c2",
        "symbol": "NR3C2",
        "name": "nuclear receptor subfamily 3 group C member 2",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/nr3c2"
      },
      {
        "slug": "scnn1b",
        "symbol": "SCNN1B",
        "name": "sodium channel epithelial 1 subunit beta",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/scnn1b"
      },
      {
        "slug": "scnn1g",
        "symbol": "SCNN1G",
        "name": "sodium channel epithelial 1 subunit gamma",
        "shared": 1,
        "url": "https://dantelabs.com/pl/genes/scnn1g"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}