{
  "url": "https://dantelabs.com/traits/verrucae",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "verrucae",
    "id": "HP:0200043",
    "name": "Warts",
    "label": "Verrucae",
    "definition": "Warts, benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "papilloma",
        "name": "Papilloma",
        "url": "https://dantelabs.com/traits/papilloma"
      }
    ],
    "narrower": [
      {
        "slug": "disseminated-cutaneous-warts",
        "name": "Disseminated cutaneous warts",
        "genes": 5,
        "url": "https://dantelabs.com/traits/disseminated-cutaneous-warts"
      },
      {
        "slug": "genital-warts",
        "name": "Genital warts",
        "genes": 2,
        "url": "https://dantelabs.com/traits/genital-warts"
      },
      {
        "slug": "verruca-plana",
        "name": "Flat wart",
        "genes": 1,
        "url": "https://dantelabs.com/traits/verruca-plana"
      }
    ],
    "genes": [
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "cib1",
        "symbol": "CIB1",
        "hgnc": "HGNC:16920",
        "name": "calcium and integrin binding 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cib1"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "pdcd1",
        "symbol": "PDCD1",
        "hgnc": "HGNC:8760",
        "name": "programmed cell death 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdcd1"
      },
      {
        "slug": "pold1",
        "symbol": "POLD1",
        "hgnc": "HGNC:9175",
        "name": "DNA polymerase delta 1, catalytic subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pold1"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "hgnc": "HGNC:18276",
        "name": "SEC61 translocon subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      },
      {
        "slug": "stk4",
        "symbol": "STK4",
        "hgnc": "HGNC:11408",
        "name": "serine/threonine kinase 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk4"
      },
      {
        "slug": "dock8",
        "symbol": "DOCK8",
        "hgnc": "HGNC:19191",
        "name": "dedicator of cytokinesis 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock8"
      },
      {
        "slug": "il7",
        "symbol": "IL7",
        "hgnc": "HGNC:6023",
        "name": "interleukin 7",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/il7"
      },
      {
        "slug": "tmc6",
        "symbol": "TMC6",
        "hgnc": "HGNC:18021",
        "name": "transmembrane channel like 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tmc6"
      },
      {
        "slug": "tmc8",
        "symbol": "TMC8",
        "hgnc": "HGNC:20474",
        "name": "transmembrane channel like 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmc8"
      },
      {
        "slug": "atp2a2",
        "symbol": "ATP2A2",
        "hgnc": "HGNC:812",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2a2"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "hgnc": "HGNC:27089",
        "name": "capping protein regulator and myosin 1 linker 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/carmil2"
      },
      {
        "slug": "cxcr4",
        "symbol": "CXCR4",
        "hgnc": "HGNC:2561",
        "name": "C-X-C motif chemokine receptor 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cxcr4"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "ecm1",
        "symbol": "ECM1",
        "hgnc": "HGNC:3153",
        "name": "extracellular matrix protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ecm1"
      },
      {
        "slug": "rnf31",
        "symbol": "RNF31",
        "hgnc": "HGNC:16031",
        "name": "ring finger protein 31",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf31"
      },
      {
        "slug": "sash3",
        "symbol": "SASH3",
        "hgnc": "HGNC:15975",
        "name": "SAM and SH3 domain containing 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sash3"
      },
      {
        "slug": "blnk",
        "symbol": "BLNK",
        "hgnc": "HGNC:14211",
        "name": "B cell linker",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blnk"
      },
      {
        "slug": "cd79a",
        "symbol": "CD79A",
        "hgnc": "HGNC:1698",
        "name": "CD79a molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79a"
      },
      {
        "slug": "cd79b",
        "symbol": "CD79B",
        "hgnc": "HGNC:1699",
        "name": "CD79b molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79b"
      },
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "ighm",
        "symbol": "IGHM",
        "hgnc": "HGNC:5541",
        "name": "immunoglobulin heavy constant mu",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighm"
      },
      {
        "slug": "igll1",
        "symbol": "IGLL1",
        "hgnc": "HGNC:5870",
        "name": "immunoglobulin lambda like polypeptide 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igll1"
      },
      {
        "slug": "lrrc8a",
        "symbol": "LRRC8A",
        "hgnc": "HGNC:19027",
        "name": "leucine rich repeat containing 8 VRAC subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc8a"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "pik3r1",
        "symbol": "PIK3R1",
        "hgnc": "HGNC:8979",
        "name": "phosphoinositide-3-kinase regulatory subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3r1"
      },
      {
        "slug": "spi1",
        "symbol": "SPI1",
        "hgnc": "HGNC:11241",
        "name": "Spi-1 proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spi1"
      },
      {
        "slug": "tcf3",
        "symbol": "TCF3",
        "hgnc": "HGNC:11633",
        "name": "transcription factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf3"
      },
      {
        "slug": "fcn3",
        "symbol": "FCN3",
        "hgnc": "HGNC:3625",
        "name": "ficolin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcn3"
      },
      {
        "slug": "ivns1abp",
        "symbol": "IVNS1ABP",
        "hgnc": "HGNC:16951",
        "name": "influenza virus NS1A binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivns1abp"
      }
    ]
  }
}