{
  "url": "https://dantelabs.com/traits/ulcerative-colitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ulcerative-colitis",
    "id": "HP:0100279",
    "name": "Ulcerative colitis",
    "definition": "A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon.",
    "synonyms": [
      "Colitis ulcerosa"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "chronic-colitis",
        "name": "Chronic colitis",
        "url": "https://dantelabs.com/traits/chronic-colitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "il37",
        "symbol": "IL37",
        "hgnc": "HGNC:15563",
        "name": "interleukin 37",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il37"
      },
      {
        "slug": "masp2",
        "symbol": "MASP2",
        "hgnc": "HGNC:6902",
        "name": "MBL associated serine protease 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/masp2"
      },
      {
        "slug": "bach2",
        "symbol": "BACH2",
        "hgnc": "HGNC:14078",
        "name": "BACH transcriptional regulator 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bach2"
      },
      {
        "slug": "gpr35",
        "symbol": "GPR35",
        "hgnc": "HGNC:4492",
        "name": "G protein-coupled receptor 35",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr35"
      },
      {
        "slug": "mst1",
        "symbol": "MST1",
        "hgnc": "HGNC:7380",
        "name": "macrophage stimulating 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mst1"
      },
      {
        "slug": "plcg2",
        "symbol": "PLCG2",
        "hgnc": "HGNC:9066",
        "name": "phospholipase C gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcg2"
      },
      {
        "slug": "sema4d",
        "symbol": "SEMA4D",
        "hgnc": "HGNC:10732",
        "name": "semaphorin 4D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema4d"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "tcf4",
        "symbol": "TCF4",
        "hgnc": "HGNC:11634",
        "name": "transcription factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf4"
      },
      {
        "slug": "card11",
        "symbol": "CARD11",
        "hgnc": "HGNC:16393",
        "name": "caspase recruitment domain family member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card11"
      },
      {
        "slug": "cybc1",
        "symbol": "CYBC1",
        "hgnc": "HGNC:28672",
        "name": "cytochrome b-245 chaperone 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybc1"
      },
      {
        "slug": "dock11",
        "symbol": "DOCK11",
        "hgnc": "HGNC:23483",
        "name": "dedicator of cytokinesis 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock11"
      },
      {
        "slug": "map3k7",
        "symbol": "MAP3K7",
        "hgnc": "HGNC:6859",
        "name": "mitogen-activated protein kinase kinase kinase 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k7"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "il6",
        "symbol": "IL6",
        "hgnc": "HGNC:6018",
        "name": "interleukin 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il6"
      },
      {
        "slug": "inava",
        "symbol": "INAVA",
        "hgnc": "HGNC:25599",
        "name": "innate immunity activator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inava"
      },
      {
        "slug": "nod2",
        "symbol": "NOD2",
        "hgnc": "HGNC:5331",
        "name": "nucleotide binding oligomerization domain containing 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nod2"
      }
    ]
  }
}