{
  "url": "https://dantelabs.com/traits/spotty-hyperpigmentation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "spotty-hyperpigmentation",
    "id": "HP:0005585",
    "name": "Spotty increased pigmentation",
    "label": "Spotty hyperpigmentation",
    "synonyms": [
      "Patchy hyperpigmentation"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "irregular-hyperpigmentation",
        "name": "Irregular hyperpigmentation",
        "url": "https://dantelabs.com/traits/irregular-hyperpigmentation"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "banf1",
        "symbol": "BANF1",
        "hgnc": "HGNC:17397",
        "name": "barrier to autointegration nuclear assembly factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/banf1"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "pde11a",
        "symbol": "PDE11A",
        "hgnc": "HGNC:8773",
        "name": "phosphodiesterase 11A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde11a"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "srd5a3",
        "symbol": "SRD5A3",
        "hgnc": "HGNC:25812",
        "name": "steroid 5 alpha-reductase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srd5a3"
      },
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyst"
      },
      {
        "slug": "cript",
        "symbol": "CRIPT",
        "hgnc": "HGNC:14312",
        "name": "CXXC repeat containing interactor of PDZ3 domain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cript"
      },
      {
        "slug": "fermt1",
        "symbol": "FERMT1",
        "hgnc": "HGNC:15889",
        "name": "FERM domain containing kindlin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fermt1"
      }
    ]
  }
}