{
  "url": "https://dantelabs.com/traits/sparse-lateral-eyebrow",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "sparse-lateral-eyebrow",
    "id": "HP:0005338",
    "name": "Limited hair on end of eyebrow",
    "label": "Sparse lateral eyebrow",
    "definition": "Decreased density/number and/or decreased diameter of lateral eyebrow hairs.",
    "synonyms": [
      "Lateral hypoplasia of eyebrows",
      "Lateral thinning of eyebrows",
      "Laterally sparse eyebrow",
      "Laterally sparse eyebrows"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "sparse-eyebrow",
        "name": "Sparse eyebrow",
        "url": "https://dantelabs.com/traits/sparse-eyebrow"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "donson",
        "symbol": "DONSON",
        "hgnc": "HGNC:2993",
        "name": "DNA replication fork stabilization factor DONSON",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/donson"
      },
      {
        "slug": "hephl1",
        "symbol": "HEPHL1",
        "hgnc": "HGNC:30477",
        "name": "hephaestin like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hephl1"
      },
      {
        "slug": "irx5",
        "symbol": "IRX5",
        "hgnc": "HGNC:14361",
        "name": "iroquois homeobox 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irx5"
      },
      {
        "slug": "kdf1",
        "symbol": "KDF1",
        "hgnc": "HGNC:26624",
        "name": "keratinocyte differentiation factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdf1"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "ppp1cb",
        "symbol": "PPP1CB",
        "hgnc": "HGNC:9282",
        "name": "protein phosphatase 1 catalytic subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1cb"
      },
      {
        "slug": "trps1",
        "symbol": "TRPS1",
        "hgnc": "HGNC:12340",
        "name": "transcriptional repressor GATA binding 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trps1"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      },
      {
        "slug": "cog6",
        "symbol": "COG6",
        "hgnc": "HGNC:18621",
        "name": "component of oligomeric golgi complex 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog6"
      },
      {
        "slug": "hnrnpk",
        "symbol": "HNRNPK",
        "hgnc": "HGNC:5044",
        "name": "heterogeneous nuclear ribonucleoprotein K",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpk"
      },
      {
        "slug": "kat5",
        "symbol": "KAT5",
        "hgnc": "HGNC:5275",
        "name": "lysine acetyltransferase 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kat5"
      },
      {
        "slug": "man1b1",
        "symbol": "MAN1B1",
        "hgnc": "HGNC:6823",
        "name": "mannosidase alpha class 1B member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man1b1"
      },
      {
        "slug": "nectin1",
        "symbol": "NECTIN1",
        "hgnc": "HGNC:9706",
        "name": "nectin cell adhesion molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin1"
      },
      {
        "slug": "pigl",
        "symbol": "PIGL",
        "hgnc": "HGNC:8966",
        "name": "phosphatidylinositol glycan anchor biosynthesis class L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigl"
      },
      {
        "slug": "pura",
        "symbol": "PURA",
        "hgnc": "HGNC:9701",
        "name": "purine rich element binding protein A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pura"
      },
      {
        "slug": "tshz3",
        "symbol": "TSHZ3",
        "hgnc": "HGNC:30700",
        "name": "teashirt zinc finger homeobox 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshz3"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist2"
      },
      {
        "slug": "usb1",
        "symbol": "USB1",
        "hgnc": "HGNC:25792",
        "name": "U6 snRNA biogenesis phosphodiesterase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usb1"
      },
      {
        "slug": "wdr26",
        "symbol": "WDR26",
        "hgnc": "HGNC:21208",
        "name": "WD repeat domain 26",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wdr26"
      },
      {
        "slug": "wls",
        "symbol": "WLS",
        "hgnc": "HGNC:30238",
        "name": "Wnt ligand secretion mediator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wls"
      },
      {
        "slug": "cdc42bpb",
        "symbol": "CDC42BPB",
        "hgnc": "HGNC:1738",
        "name": "CDC42 binding protein kinase beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc42bpb"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "kmt5b",
        "symbol": "KMT5B",
        "hgnc": "HGNC:24283",
        "name": "lysine methyltransferase 5B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt5b"
      },
      {
        "slug": "krt25",
        "symbol": "KRT25",
        "hgnc": "HGNC:30839",
        "name": "keratin 25",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt25"
      },
      {
        "slug": "krt71",
        "symbol": "KRT71",
        "hgnc": "HGNC:28927",
        "name": "keratin 71",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt71"
      },
      {
        "slug": "krt74",
        "symbol": "KRT74",
        "hgnc": "HGNC:28929",
        "name": "keratin 74",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt74"
      },
      {
        "slug": "liph",
        "symbol": "LIPH",
        "hgnc": "HGNC:18483",
        "name": "lipase H",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/liph"
      },
      {
        "slug": "lmbrd2",
        "symbol": "LMBRD2",
        "hgnc": "HGNC:25287",
        "name": "LMBR1 domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbrd2"
      },
      {
        "slug": "lpar6",
        "symbol": "LPAR6",
        "hgnc": "HGNC:15520",
        "name": "lysophosphatidic acid receptor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lpar6"
      },
      {
        "slug": "mesd",
        "symbol": "MESD",
        "hgnc": "HGNC:13520",
        "name": "mesoderm development LRP chaperone",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mesd"
      },
      {
        "slug": "plxna1",
        "symbol": "PLXNA1",
        "hgnc": "HGNC:9099",
        "name": "plexin A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plxna1"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "hgnc": "HGNC:14341",
        "name": "EDAR associated via death domain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edaradd"
      },
      {
        "slug": "pigk",
        "symbol": "PIGK",
        "hgnc": "HGNC:8965",
        "name": "phosphatidylinositol glycan anchor biosynthesis class K",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigk"
      },
      {
        "slug": "pqbp1",
        "symbol": "PQBP1",
        "hgnc": "HGNC:9330",
        "name": "polyglutamine binding protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pqbp1"
      },
      {
        "slug": "tbx3",
        "symbol": "TBX3",
        "hgnc": "HGNC:11602",
        "name": "T-box transcription factor 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx3"
      }
    ]
  }
}