{
  "url": "https://dantelabs.com/traits/small-joint-hypermobility",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "small-joint-hypermobility",
    "id": "HP:0430046",
    "name": "Small joint hypermobility",
    "definition": "The capability that a small joint (or a group of joints) has to move, passively and/or actively, beyond normal limits along physiological axes. Small joints include metacarpophalangeal joints, proximal interphalangeal joints, nsecond to fifth metatarsophalangeal joints, and wrists.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      }
    ],
    "narrower": [
      {
        "slug": "finger-joint-hypermobility",
        "name": "Increased mobility in finger joint",
        "genes": 19,
        "url": "https://dantelabs.com/traits/finger-joint-hypermobility"
      },
      {
        "slug": "distal-joint-hypermobility",
        "name": "Distal joint hypermobility",
        "genes": 13,
        "url": "https://dantelabs.com/traits/distal-joint-hypermobility"
      },
      {
        "slug": "wrist-hypermobility",
        "name": "Increased wrist mobility",
        "genes": 7,
        "url": "https://dantelabs.com/traits/wrist-hypermobility"
      },
      {
        "slug": "hyperextensibility-at-elbow",
        "name": "Hyperextensibility at elbow",
        "genes": 6,
        "url": "https://dantelabs.com/traits/hyperextensibility-at-elbow"
      },
      {
        "slug": "hyperextensible-hand-joints",
        "name": "Hyperextensible hand joints",
        "genes": 4,
        "url": "https://dantelabs.com/traits/hyperextensible-hand-joints"
      },
      {
        "slug": "hypermobility-of-interphalangeal-joints",
        "name": "Increased mobility of hinge joints",
        "genes": 4,
        "url": "https://dantelabs.com/traits/hypermobility-of-interphalangeal-joints"
      }
    ],
    "genes": [
      {
        "slug": "fkbp14",
        "symbol": "FKBP14",
        "hgnc": "HGNC:18625",
        "name": "FKBP prolyl isomerase 14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp14"
      },
      {
        "slug": "plaa",
        "symbol": "PLAA",
        "hgnc": "HGNC:9043",
        "name": "phospholipase A2 activating protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plaa"
      },
      {
        "slug": "cdk10",
        "symbol": "CDK10",
        "hgnc": "HGNC:1770",
        "name": "cyclin dependent kinase 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk10"
      },
      {
        "slug": "emilin1",
        "symbol": "EMILIN1",
        "hgnc": "HGNC:19880",
        "name": "elastin microfibril interfacer 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emilin1"
      },
      {
        "slug": "gtpbp2",
        "symbol": "GTPBP2",
        "hgnc": "HGNC:4670",
        "name": "GTP binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp2"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv4"
      }
    ]
  }
}