{
  "url": "https://dantelabs.com/traits/sclerodactyly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "sclerodactyly",
    "id": "HP:0011838",
    "name": "Sclerodactyly",
    "definition": "Localized thickening and tightness of the skin of the fingers or toes.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "thickened-skin",
        "name": "Thickened skin",
        "url": "https://dantelabs.com/traits/thickened-skin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "smarcad1",
        "symbol": "SMARCAD1",
        "hgnc": "HGNC:18398",
        "name": "SNF2 related chromatin remodeling ATPase with DExD box 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcad1"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "rspo1",
        "symbol": "RSPO1",
        "hgnc": "HGNC:21679",
        "name": "R-spondin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo1"
      }
    ]
  }
}