{
  "url": "https://dantelabs.com/traits/reduced-factor-x-activity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "reduced-factor-x-activity",
    "id": "HP:0008321",
    "name": "Reduced factor X activity",
    "definition": "Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa).",
    "synonyms": [
      "Decreased factor x activity"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-common-coagulation-pathway",
        "name": "Abnormality of the common coagulation pathway",
        "url": "https://dantelabs.com/traits/abnormality-of-the-common-coagulation-pathway"
      }
    ],
    "narrower": [
      {
        "slug": "factor-x-activation-deficiency",
        "name": "Factor X activation deficiency",
        "genes": 1,
        "url": "https://dantelabs.com/traits/factor-x-activation-deficiency"
      }
    ],
    "genes": [
      {
        "slug": "f10",
        "symbol": "F10",
        "hgnc": "HGNC:3528",
        "name": "coagulation factor X",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f10"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "hgnc": "HGNC:23663",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vkorc1"
      }
    ]
  }
}