{
  "url": "https://dantelabs.com/traits/prolinuria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "prolinuria",
    "id": "HP:0003137",
    "name": "Prolinuria",
    "definition": "Level of proline in the urine anove the upper limit of normal.",
    "synonyms": [
      "Proline high in urine"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "increased-proteinogenic-amino-acid-level-in-urine",
        "name": "Increased proteinogenic amino acid level in urine",
        "url": "https://dantelabs.com/traits/increased-proteinogenic-amino-acid-level-in-urine"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "slc36a2",
        "symbol": "SLC36A2",
        "hgnc": "HGNC:18762",
        "name": "solute carrier family 36 member 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc36a2"
      },
      {
        "slug": "slc6a18",
        "symbol": "SLC6A18",
        "hgnc": "HGNC:26441",
        "name": "solute carrier family 6 member 18",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a18"
      },
      {
        "slug": "slc6a19",
        "symbol": "SLC6A19",
        "hgnc": "HGNC:27960",
        "name": "solute carrier family 6 member 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a19"
      },
      {
        "slug": "slc6a20",
        "symbol": "SLC6A20",
        "hgnc": "HGNC:30927",
        "name": "solute carrier family 6 member 20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a20"
      },
      {
        "slug": "aldh4a1",
        "symbol": "ALDH4A1",
        "hgnc": "HGNC:406",
        "name": "aldehyde dehydrogenase 4 family member A1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aldh4a1"
      },
      {
        "slug": "prodh",
        "symbol": "PRODH",
        "hgnc": "HGNC:9453",
        "name": "proline dehydrogenase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prodh"
      },
      {
        "slug": "oplah",
        "symbol": "OPLAH",
        "hgnc": "HGNC:8149",
        "name": "5-oxoprolinase, ATP-hydrolysing",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oplah"
      }
    ]
  }
}