{
  "url": "https://dantelabs.com/traits/progressive-ptosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "progressive-ptosis",
    "id": "HP:0007838",
    "name": "Progressive drooping of upper eyelid",
    "label": "Progressive ptosis",
    "definition": "A progressive form of ptosis.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "url": "https://dantelabs.com/traits/ptosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "pabpn1",
        "symbol": "PABPN1",
        "hgnc": "HGNC:8565",
        "name": "poly(A) binding protein nuclear 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pabpn1"
      },
      {
        "slug": "abcd3",
        "symbol": "ABCD3",
        "hgnc": "HGNC:67",
        "name": "ATP binding cassette subfamily D member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd3"
      },
      {
        "slug": "gipc1",
        "symbol": "GIPC1",
        "hgnc": "HGNC:1226",
        "name": "GIPC PDZ domain containing family member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gipc1"
      },
      {
        "slug": "lrp12",
        "symbol": "LRP12",
        "hgnc": "HGNC:31708",
        "name": "LDL receptor related protein 12",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp12"
      },
      {
        "slug": "notch2nlc",
        "symbol": "NOTCH2NLC",
        "hgnc": "HGNC:53924",
        "name": "notch 2 N-terminal like C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch2nlc"
      },
      {
        "slug": "nutm2b-as1",
        "symbol": "NUTM2B-AS1",
        "hgnc": "HGNC:51204",
        "name": "NUTM2B antisense RNA 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nutm2b-as1"
      },
      {
        "slug": "rilpl1",
        "symbol": "RILPL1",
        "hgnc": "HGNC:26814",
        "name": "Rab interacting lysosomal protein like 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rilpl1"
      }
    ]
  }
}