{
  "url": "https://dantelabs.com/traits/megacystis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "megacystis",
    "id": "HP:0000021",
    "name": "Megacystis",
    "definition": "Dilatation of the bladder postnatally.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "dilatation-of-the-bladder",
        "name": "Dilatation of the bladder",
        "url": "https://dantelabs.com/traits/dilatation-of-the-bladder"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "actg2",
        "symbol": "ACTG2",
        "hgnc": "HGNC:145",
        "name": "actin gamma 2, smooth muscle",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/actg2"
      },
      {
        "slug": "myh11",
        "symbol": "MYH11",
        "hgnc": "HGNC:7569",
        "name": "myosin heavy chain 11",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/myh11"
      },
      {
        "slug": "myl9",
        "symbol": "MYL9",
        "hgnc": "HGNC:15754",
        "name": "myosin light chain 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myl9"
      },
      {
        "slug": "lmod1",
        "symbol": "LMOD1",
        "hgnc": "HGNC:6647",
        "name": "leiomodin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmod1"
      },
      {
        "slug": "mylk",
        "symbol": "MYLK",
        "hgnc": "HGNC:7590",
        "name": "myosin light chain kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mylk"
      },
      {
        "slug": "lrig2",
        "symbol": "LRIG2",
        "hgnc": "HGNC:20889",
        "name": "leucine rich repeats and immunoglobulin like domains 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrig2"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      },
      {
        "slug": "aqp2",
        "symbol": "AQP2",
        "hgnc": "HGNC:634",
        "name": "aquaporin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aqp2"
      },
      {
        "slug": "avpr2",
        "symbol": "AVPR2",
        "hgnc": "HGNC:897",
        "name": "arginine vasopressin receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/avpr2"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      }
    ]
  }
}