{
  "url": "https://dantelabs.com/traits/malnutrition",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "malnutrition",
    "id": "HP:0004395",
    "name": "Malnutrition",
    "definition": "A deficiency in the intake of energy and nutrients.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abdominal-symptom",
        "name": "Abdominal symptom",
        "url": "https://dantelabs.com/traits/abdominal-symptom"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "get4",
        "symbol": "GET4",
        "hgnc": "HGNC:21690",
        "name": "guided entry of tail-anchored proteins factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/get4"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "atp6v0a1",
        "symbol": "ATP6V0A1",
        "hgnc": "HGNC:865",
        "name": "ATPase H+ transporting V0 subunit a1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v0a1"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "dnajc21",
        "symbol": "DNAJC21",
        "hgnc": "HGNC:27030",
        "name": "DnaJ heat shock protein family (Hsp40) member C21",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc21"
      },
      {
        "slug": "efl1",
        "symbol": "EFL1",
        "hgnc": "HGNC:25789",
        "name": "elongation factor like GTPase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efl1"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamc2"
      },
      {
        "slug": "lipa",
        "symbol": "LIPA",
        "hgnc": "HGNC:6617",
        "name": "lipase A, lysosomal acid type",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipa"
      },
      {
        "slug": "saa1",
        "symbol": "SAA1",
        "hgnc": "HGNC:10513",
        "name": "serum amyloid A1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/saa1"
      },
      {
        "slug": "sbds",
        "symbol": "SBDS",
        "hgnc": "HGNC:19440",
        "name": "SBDS ribosome maturation factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sbds"
      },
      {
        "slug": "slc5a1",
        "symbol": "SLC5A1",
        "hgnc": "HGNC:11036",
        "name": "solute carrier family 5 member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a1"
      },
      {
        "slug": "arhgap29",
        "symbol": "ARHGAP29",
        "hgnc": "HGNC:30207",
        "name": "Rho GTPase activating protein 29",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgap29"
      },
      {
        "slug": "arhgef38",
        "symbol": "ARHGEF38",
        "hgnc": "HGNC:25968",
        "name": "Rho guanine nucleotide exchange factor 38",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgef38"
      },
      {
        "slug": "bmp4",
        "symbol": "BMP4",
        "hgnc": "HGNC:1071",
        "name": "bone morphogenetic protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp4"
      },
      {
        "slug": "cdh1",
        "symbol": "CDH1",
        "hgnc": "HGNC:1748",
        "name": "cadherin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh1"
      },
      {
        "slug": "cobll1",
        "symbol": "COBLL1",
        "hgnc": "HGNC:23571",
        "name": "cordon-bleu WH2 repeat protein like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cobll1"
      },
      {
        "slug": "crlf1",
        "symbol": "CRLF1",
        "hgnc": "HGNC:2364",
        "name": "cytokine receptor like factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crlf1"
      },
      {
        "slug": "ctrc",
        "symbol": "CTRC",
        "hgnc": "HGNC:2523",
        "name": "chymotrypsin C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctrc"
      },
      {
        "slug": "dlg1",
        "symbol": "DLG1",
        "hgnc": "HGNC:2900",
        "name": "discs large MAGUK scaffold protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlg1"
      },
      {
        "slug": "dlx4",
        "symbol": "DLX4",
        "hgnc": "HGNC:2917",
        "name": "distal-less homeobox 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlx4"
      },
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "hla-dqa1",
        "symbol": "HLA-DQA1",
        "hgnc": "HGNC:4942",
        "name": "major histocompatibility complex, class II, DQ alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dqa1"
      },
      {
        "slug": "hla-dqb1",
        "symbol": "HLA-DQB1",
        "hgnc": "HGNC:4944",
        "name": "major histocompatibility complex, class II, DQ beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dqb1"
      },
      {
        "slug": "irf6",
        "symbol": "IRF6",
        "hgnc": "HGNC:6121",
        "name": "interferon regulatory factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf6"
      },
      {
        "slug": "lmnb1",
        "symbol": "LMNB1",
        "hgnc": "HGNC:6637",
        "name": "lamin B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb1"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "hgnc": "HGNC:7391",
        "name": "msh homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx1"
      },
      {
        "slug": "nectin1",
        "symbol": "NECTIN1",
        "hgnc": "HGNC:9706",
        "name": "nectin cell adhesion molecule 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin1"
      },
      {
        "slug": "nos1",
        "symbol": "NOS1",
        "hgnc": "HGNC:7872",
        "name": "nitric oxide synthase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nos1"
      },
      {
        "slug": "pdgfra",
        "symbol": "PDGFRA",
        "hgnc": "HGNC:8803",
        "name": "platelet derived growth factor receptor alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfra"
      },
      {
        "slug": "ric1",
        "symbol": "RIC1",
        "hgnc": "HGNC:17686",
        "name": "RIC1 partner of RAB6A GEF complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ric1"
      },
      {
        "slug": "spink1",
        "symbol": "SPINK1",
        "hgnc": "HGNC:11244",
        "name": "serine peptidase inhibitor Kazal type 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink1"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "actg2",
        "symbol": "ACTG2",
        "hgnc": "HGNC:145",
        "name": "actin gamma 2, smooth muscle",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actg2"
      },
      {
        "slug": "aldob",
        "symbol": "ALDOB",
        "hgnc": "HGNC:417",
        "name": "aldolase, fructose-bisphosphate B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldob"
      },
      {
        "slug": "cox4i2",
        "symbol": "COX4I2",
        "hgnc": "HGNC:16232",
        "name": "cytochrome c oxidase subunit 4I2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox4i2"
      },
      {
        "slug": "myo5b",
        "symbol": "MYO5B",
        "hgnc": "HGNC:7603",
        "name": "myosin VB",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo5b"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "sar1b",
        "symbol": "SAR1B",
        "hgnc": "HGNC:10535",
        "name": "secretion associated Ras related GTPase 1B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sar1b"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "tymp",
        "symbol": "TYMP",
        "hgnc": "HGNC:3148",
        "name": "thymidine phosphorylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tymp"
      }
    ]
  }
}