{
  "url": "https://dantelabs.com/traits/hbh-hemoglobin",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hbh-hemoglobin",
    "id": "HP:0011903",
    "name": "HbH hemoglobin",
    "definition": "Hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia.",
    "synonyms": [
      "Haemoglobin H",
      "HbH haemoglobin",
      "Hemoglobin H"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hemoglobin",
        "name": "Abnormal hemoglobin",
        "url": "https://dantelabs.com/traits/abnormal-hemoglobin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "hba1",
        "symbol": "HBA1",
        "hgnc": "HGNC:4823",
        "name": "hemoglobin subunit alpha 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hba1"
      },
      {
        "slug": "hba2",
        "symbol": "HBA2",
        "hgnc": "HGNC:4824",
        "name": "hemoglobin subunit alpha 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hba2"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prps1"
      }
    ]
  }
}