{
  "url": "https://dantelabs.com/traits/chondrocalcinosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "chondrocalcinosis",
    "id": "HP:0000934",
    "name": "Calcium deposits in joints",
    "label": "Chondrocalcinosis",
    "definition": "Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) .",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-joint-morphology",
        "name": "Abnormal shape of joints",
        "url": "https://dantelabs.com/traits/abnormal-joint-morphology"
      },
      {
        "slug": "abnormal-sharpey-fiber-morphology",
        "name": "Abnormal Sharpey fiber morphology",
        "url": "https://dantelabs.com/traits/abnormal-sharpey-fiber-morphology"
      },
      {
        "slug": "ectopic-calcification",
        "name": "Ectopic calcification",
        "url": "https://dantelabs.com/traits/ectopic-calcification"
      }
    ],
    "narrower": [
      {
        "slug": "polyarticular-chondrocalcinosis",
        "name": "Polyarticular chondrocalcinosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/polyarticular-chondrocalcinosis"
      }
    ],
    "genes": [
      {
        "slug": "hyal1",
        "symbol": "HYAL1",
        "hgnc": "HGNC:5320",
        "name": "hyaluronidase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyal1"
      },
      {
        "slug": "cdc73",
        "symbol": "CDC73",
        "hgnc": "HGNC:16783",
        "name": "cell division cycle 73",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/cdc73"
      },
      {
        "slug": "gcm2",
        "symbol": "GCM2",
        "hgnc": "HGNC:4198",
        "name": "GCM transcription factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcm2"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "tnfrsf11b",
        "symbol": "TNFRSF11B",
        "hgnc": "HGNC:11909",
        "name": "TNF receptor superfamily member 11b",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11b"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "tnfrsf1a",
        "symbol": "TNFRSF1A",
        "hgnc": "HGNC:11916",
        "name": "TNF receptor superfamily member 1A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1a"
      },
      {
        "slug": "alpl",
        "symbol": "ALPL",
        "hgnc": "HGNC:438",
        "name": "alkaline phosphatase, biomineralization associated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpl"
      },
      {
        "slug": "ap2s1",
        "symbol": "AP2S1",
        "hgnc": "HGNC:565",
        "name": "adaptor related protein complex 2 subunit sigma 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap2s1"
      },
      {
        "slug": "atp7b",
        "symbol": "ATP7B",
        "hgnc": "HGNC:870",
        "name": "ATPase copper transporting beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7b"
      },
      {
        "slug": "fxyd2",
        "symbol": "FXYD2",
        "hgnc": "HGNC:4026",
        "name": "FXYD domain containing ion transport regulator 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fxyd2"
      },
      {
        "slug": "gna11",
        "symbol": "GNA11",
        "hgnc": "HGNC:4379",
        "name": "G protein subunit alpha 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gna11"
      },
      {
        "slug": "kcnj1",
        "symbol": "KCNJ1",
        "hgnc": "HGNC:6255",
        "name": "potassium inwardly rectifying channel subfamily J member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj1"
      },
      {
        "slug": "slc12a1",
        "symbol": "SLC12A1",
        "hgnc": "HGNC:10910",
        "name": "solute carrier family 12 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a1"
      }
    ]
  }
}