{
  "url": "https://dantelabs.com/traits/cavitating-leukodystrophy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cavitating-leukodystrophy",
    "id": "HP:0033369",
    "name": "Cavitating leukodystrophy",
    "definition": "A type of leukodystrophy characterized by multiple small cavitations typically in the periventricular and deep cerebral white matter. The cavitations are visible as a central cavity with cerebrospinal fluid-like signal intensity.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "leukodystrophy",
        "name": "Leukodystrophy",
        "url": "https://dantelabs.com/traits/leukodystrophy"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "coa8",
        "symbol": "COA8",
        "hgnc": "HGNC:20492",
        "name": "cytochrome c oxidase assembly factor 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa8"
      },
      {
        "slug": "iba57",
        "symbol": "IBA57",
        "hgnc": "HGNC:27302",
        "name": "iron-sulfur cluster assembly factor IBA57",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iba57"
      }
    ]
  }
}