{
  "url": "https://dantelabs.com/traits/abnormal-limb-bone-morphology",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-limb-bone-morphology",
    "id": "HP:0002813",
    "name": "Abnormal shape of limb bone",
    "label": "Abnormal limb bone morphology",
    "definition": "Any abnormality of bones of the arms or legs.",
    "synonyms": [
      "Arm and/or leg bone differences",
      "Limb abnormality",
      "Abnormality of limb bone morphology"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-appendicular-skeleton-morphology",
        "name": "Abnormal appendicular skeleton morphology",
        "url": "https://dantelabs.com/traits/abnormal-appendicular-skeleton-morphology"
      },
      {
        "slug": "abnormality-of-limb-bone",
        "name": "Abnormality of limb bone",
        "url": "https://dantelabs.com/traits/abnormality-of-limb-bone"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-metaphysis-morphology",
        "name": "Abnormality of the wide portion of a long bone",
        "genes": 95,
        "url": "https://dantelabs.com/traits/abnormal-metaphysis-morphology"
      },
      {
        "slug": "abnormal-diaphysis-morphology",
        "name": "Abnormal shape of shaft of long bone",
        "genes": 15,
        "url": "https://dantelabs.com/traits/abnormal-diaphysis-morphology"
      },
      {
        "slug": "abnormal-digit-morphology",
        "name": "Abnormality of fingers or toes",
        "genes": 15,
        "url": "https://dantelabs.com/traits/abnormal-digit-morphology"
      },
      {
        "slug": "ectrodactyly",
        "name": "Cleft hand",
        "genes": 15,
        "url": "https://dantelabs.com/traits/ectrodactyly"
      },
      {
        "slug": "acromicria",
        "name": "Acromicria",
        "genes": 13,
        "url": "https://dantelabs.com/traits/acromicria"
      },
      {
        "slug": "aplasia-hypoplasia-involving-bones-of-the-extremities",
        "name": "Aplasia/hypoplasia involving bones of the extremities",
        "genes": 5,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-involving-bones-of-the-extremities"
      },
      {
        "slug": "abnormal-lower-limb-bone-morphology",
        "name": "Abnormal shape of bones of the lower limbs",
        "genes": 3,
        "url": "https://dantelabs.com/traits/abnormal-lower-limb-bone-morphology"
      },
      {
        "slug": "subperiosteal-bone-resorption",
        "name": "Subperiosteal bone resorption",
        "genes": 3,
        "url": "https://dantelabs.com/traits/subperiosteal-bone-resorption"
      },
      {
        "slug": "limb-duplication",
        "name": "Limb duplication",
        "genes": 1,
        "url": "https://dantelabs.com/traits/limb-duplication"
      },
      {
        "slug": "abnormal-upper-limb-bone-morphology",
        "name": "Abnormal shape of bones of the upper limbs",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-upper-limb-bone-morphology"
      },
      {
        "slug": "abnormal-limb-epiphysis-morphology",
        "name": "Abnormal shape of end part of limb bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-limb-epiphysis-morphology"
      }
    ],
    "genes": [
      {
        "slug": "alg3",
        "symbol": "ALG3",
        "hgnc": "HGNC:23056",
        "name": "ALG3 alpha-1,3- mannosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg3"
      },
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "cdh3",
        "symbol": "CDH3",
        "hgnc": "HGNC:1762",
        "name": "cadherin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh3"
      },
      {
        "slug": "gdf6",
        "symbol": "GDF6",
        "hgnc": "HGNC:4221",
        "name": "growth differentiation factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf6"
      }
    ]
  }
}