{
  "url": "https://dantelabs.com/traits/abnormal-enchondral-ossification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-enchondral-ossification",
    "id": "HP:0003336",
    "name": "Abnormal enchondral ossification",
    "definition": "An abnormality of the process of endochondral ossification, which is a type of replacement ossification in which bone tissue replaces cartilage.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-bone-ossification",
        "name": "Abnormal bone maturation",
        "url": "https://dantelabs.com/traits/abnormal-bone-ossification"
      }
    ],
    "narrower": [
      {
        "slug": "abnormally-ossified-vertebrae",
        "name": "Abnormal bone maturation of vertebra",
        "genes": 14,
        "url": "https://dantelabs.com/traits/abnormally-ossified-vertebrae"
      },
      {
        "slug": "abnormal-pelvis-bone-ossification",
        "name": "Abnormal maturation of the pelvis bone",
        "genes": 7,
        "url": "https://dantelabs.com/traits/abnormal-pelvis-bone-ossification"
      },
      {
        "slug": "abnormal-sternal-ossification",
        "name": "Abnormal maturation of breastbone",
        "genes": 5,
        "url": "https://dantelabs.com/traits/abnormal-sternal-ossification"
      },
      {
        "slug": "abnormal-ossification-involving-the-femoral-head-and-neck",
        "name": "Abnormal maturation of thigh bone head and neck",
        "genes": 4,
        "url": "https://dantelabs.com/traits/abnormal-ossification-involving-the-femoral-head-and-neck"
      },
      {
        "slug": "abnormal-foot-bone-ossification",
        "name": "Abnormal foot bone ossification",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-foot-bone-ossification"
      },
      {
        "slug": "abnormal-hand-bone-ossification",
        "name": "Abnormal maturation of the hand bones",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-hand-bone-ossification"
      },
      {
        "slug": "delayed-patellar-ossification",
        "name": "Delayed bone maturation of the knee cap",
        "genes": 2,
        "url": "https://dantelabs.com/traits/delayed-patellar-ossification"
      },
      {
        "slug": "abnormal-epiphyseal-ossification",
        "name": "Abnormal maturation of the end part of a bone",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-epiphyseal-ossification"
      },
      {
        "slug": "calcific-stippling-of-infantile-cartilaginous-skeleton",
        "name": "Calcific stippling of infantile cartilaginous skeleton",
        "genes": 1,
        "url": "https://dantelabs.com/traits/calcific-stippling-of-infantile-cartilaginous-skeleton"
      },
      {
        "slug": "abnormal-humeral-ossification",
        "name": "Abnormal maturation of long bone in upper arm",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-humeral-ossification"
      },
      {
        "slug": "abnormal-rib-ossification",
        "name": "Abnormal maturation of rib bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-rib-ossification"
      }
    ],
    "genes": [
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/trpv4"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      },
      {
        "slug": "trip11",
        "symbol": "TRIP11",
        "hgnc": "HGNC:12305",
        "name": "thyroid hormone receptor interactor 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip11"
      }
    ]
  }
}