{
  "url": "https://dantelabs.com/traits/abnormal-digit-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-digit-morphology",
    "id": "HP:0011297",
    "name": "Abnormality of fingers or toes",
    "label": "Abnormal digit morphology",
    "definition": "A morphological abnormality of a digit, i.e., of a finger or toe.",
    "synonyms": [
      "Abnormality of digit",
      "Digital anomalies"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-limb-bone-morphology",
        "name": "Abnormal shape of limb bone",
        "url": "https://dantelabs.com/traits/abnormal-limb-bone-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "clinodactyly",
        "name": "Curvature of digit",
        "genes": 201,
        "url": "https://dantelabs.com/traits/clinodactyly"
      },
      {
        "slug": "syndactyly",
        "name": "Webbed fingers or toes",
        "genes": 159,
        "url": "https://dantelabs.com/traits/syndactyly"
      },
      {
        "slug": "clubbing",
        "name": "Clubbing of fingers and toes",
        "genes": 103,
        "url": "https://dantelabs.com/traits/clubbing"
      },
      {
        "slug": "polydactyly",
        "name": "More than five fingers or toes on hands or feet",
        "genes": 69,
        "url": "https://dantelabs.com/traits/polydactyly"
      },
      {
        "slug": "oligodactyly",
        "name": "Oligodactyly",
        "genes": 28,
        "url": "https://dantelabs.com/traits/oligodactyly"
      },
      {
        "slug": "abnormal-finger-morphology",
        "name": "Abnormalities of the fingers",
        "genes": 22,
        "url": "https://dantelabs.com/traits/abnormal-finger-morphology"
      },
      {
        "slug": "short-digit",
        "name": "Short digit",
        "genes": 15,
        "url": "https://dantelabs.com/traits/short-digit"
      },
      {
        "slug": "abnormal-toe-morphology",
        "name": "Abnormalities of the toes",
        "genes": 11,
        "url": "https://dantelabs.com/traits/abnormal-toe-morphology"
      },
      {
        "slug": "broad-phalanx",
        "name": "Wide digital bones",
        "genes": 10,
        "url": "https://dantelabs.com/traits/broad-phalanx"
      },
      {
        "slug": "macrodactyly",
        "name": "Finger overgrowth",
        "genes": 4,
        "url": "https://dantelabs.com/traits/macrodactyly"
      }
    ],
    "genes": [
      {
        "slug": "chsy1",
        "symbol": "CHSY1",
        "hgnc": "HGNC:17198",
        "name": "chondroitin sulfate synthase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chsy1"
      },
      {
        "slug": "lmx1b",
        "symbol": "LMX1B",
        "hgnc": "HGNC:6654",
        "name": "LIM homeobox transcription factor 1 beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmx1b"
      },
      {
        "slug": "fgf10",
        "symbol": "FGF10",
        "hgnc": "HGNC:3666",
        "name": "fibroblast growth factor 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf10"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "glmn",
        "symbol": "GLMN",
        "hgnc": "HGNC:14373",
        "name": "glomulin, FKBP associated protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glmn"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "foxa2",
        "symbol": "FOXA2",
        "hgnc": "HGNC:5022",
        "name": "forkhead box A2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxa2"
      },
      {
        "slug": "gli2",
        "symbol": "GLI2",
        "hgnc": "HGNC:4318",
        "name": "GLI family zinc finger 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli2"
      },
      {
        "slug": "hesx1",
        "symbol": "HESX1",
        "hgnc": "HGNC:4877",
        "name": "HESX homeobox 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hesx1"
      },
      {
        "slug": "lhx4",
        "symbol": "LHX4",
        "hgnc": "HGNC:21734",
        "name": "LIM homeobox 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx4"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "pou1f1",
        "symbol": "POU1F1",
        "hgnc": "HGNC:9210",
        "name": "POU class 1 homeobox 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou1f1"
      },
      {
        "slug": "prop1",
        "symbol": "PROP1",
        "hgnc": "HGNC:9455",
        "name": "PROP paired-like homeobox 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prop1"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      }
    ]
  }
}