{ "url": "https://dantelabs.com/no/genes/tnni3", "gene": { "slug": "tnni3", "symbol": "TNNI3", "name": "troponin I3, cardiac type", "hgnc": "HGNC:11947", "summary": null, "location": "19q13.42", "locusType": "gene with protein product", "aliases": [ "TNNC1", "CMH7", "cTNI" ], "previousSymbols": [ "CMD2A" ], "ensemblId": "ENSG00000129991", "entrezId": 7137, "omim": [ "191044" ], "uniprot": [ "P19429" ], "model": { "build": "GRCh38", "release": "v1.5", "chrom": "19", "start": 55151767, "end": 55157732, "strand": "-", "ensemblTranscript": "ENST00000344887.10", "refseqTranscript": "NM_000363.5", "ensemblProtein": "ENSP00000341838.5", "refseqProtein": "NP_000354.4", "exons": [ { "start": 55151767, "end": 55151917 }, { "start": 55154030, "end": 55154206 }, { "start": 55154741, "end": 55154830 }, { "start": 55156201, "end": 55156332 }, { "start": 55156603, "end": 55156644 }, { "start": 55157050, "end": 55157133 }, { "start": 55157296, "end": 55157308 }, { "start": 55157579, "end": 55157732 } ], "cds": { "start": 55151834, "end": 55157589 } }, "grch37": { "build": "GRCh37", "release": "87", "chrom": "19", "start": 55663137, "end": 55669141, "strand": "-" }, "neighbourhood": { "release": "116", "start": 54654750, "end": 55654749, "genes": [ { "symbol": "LILRB4", "ensemblId": "ENSG00000186818", "biotype": "protein_coding", "start": 54643889, "end": 54670531, "strand": "+", "slug": "lilrb4" }, { "symbol": "KIR3DL3", "ensemblId": "ENSG00000242019", "biotype": "protein_coding", "start": 54724442, "end": 54736632, "strand": "+", "slug": "kir3dl3" }, { "symbol": "KIR2DL3", "ensemblId": "ENSG00000243772", "biotype": "protein_coding", "start": 54738505, "end": 54753061, "strand": "+", "slug": "kir2dl3" }, { "symbol": "KIR2DL1", "ensemblId": "ENSG00000125498", "biotype": "protein_coding", "start": 54769793, "end": 54784332, "strand": "+", "slug": "kir2dl1" }, { "symbol": "KIR2DL4", "ensemblId": "ENSG00000189013", "biotype": "protein_coding", "start": 54803610, "end": 54814517, "strand": "+", "slug": "kir2dl4" }, { "symbol": "KIR3DL1", "ensemblId": "ENSG00000167633", "biotype": "protein_coding", "start": 54816440, "end": 54830778, "strand": "+", "slug": "kir3dl1" }, { "symbol": "KIR2DS4", "ensemblId": "ENSG00000221957", "biotype": "protein_coding", "start": 54832676, "end": 54848569, "strand": "+", "slug": "kir2ds4" }, { "symbol": "KIR3DL2", "ensemblId": "ENSG00000240403", "biotype": "protein_coding", "start": 54850433, "end": 54867209, "strand": "+", "slug": "kir3dl2" }, { "symbol": "FCAR", "ensemblId": "ENSG00000186431", "biotype": "protein_coding", "start": 54874227, "end": 54891420, "strand": "+", "slug": "fcar" }, { "symbol": "NCR1", "ensemblId": "ENSG00000189430", "biotype": "protein_coding", "start": 54906112, "end": 54941199, "strand": "+", "slug": "ncr1" }, { "symbol": "NLRP7", "ensemblId": "ENSG00000167634", "biotype": "protein_coding", "start": 54923454, "end": 54966312, "strand": "-", "slug": "nlrp7" }, { "symbol": "NLRP2", "ensemblId": "ENSG00000022556", "biotype": "protein_coding", "start": 54953130, "end": 55001142, "strand": "+", "slug": "nlrp2" }, { "symbol": "GP6", "ensemblId": "ENSG00000088053", "biotype": "protein_coding", "start": 55012055, "end": 55038264, "strand": "-", "slug": "gp6" }, { "symbol": "RDH13", "ensemblId": "ENSG00000160439", "biotype": "protein_coding", "start": 55039108, "end": 55071291, "strand": "-", "slug": "rdh13" }, { "symbol": "EPS8L1", "ensemblId": "ENSG00000131037", "biotype": "protein_coding", "start": 55072020, "end": 55090124, "strand": "+", "slug": "eps8l1" }, { "symbol": "PPP1R12C", "ensemblId": "ENSG00000125503", "biotype": "protein_coding", "start": 55090913, "end": 55117679, "strand": "-", "slug": "ppp1r12c" }, { "symbol": "TNNT1", "ensemblId": "ENSG00000105048", "biotype": "protein_coding", "start": 55131662, "end": 55149351, "strand": "-", "slug": "tnnt1" }, { "symbol": "", "ensemblId": "ENSG00000267110", "biotype": "protein_coding", "start": 55154757, "end": 55160671, "strand": "-" }, { "symbol": "DNAAF3", "ensemblId": "ENSG00000167646", "biotype": "protein_coding", "start": 55158661, "end": 55166722, "strand": "-", "slug": "dnaaf3" }, { "symbol": "SYT5", "ensemblId": "ENSG00000129990", "biotype": "protein_coding", "start": 55171196, "end": 55180328, "strand": "-", "slug": "syt5" }, { "symbol": "PTPRH", "ensemblId": "ENSG00000080031", "biotype": "protein_coding", "start": 55181230, "end": 55209512, "strand": "-", "slug": "ptprh" }, { "symbol": "TMEM86B", "ensemblId": "ENSG00000180089", "biotype": "protein_coding", "start": 55226524, "end": 55228784, "strand": "-", "slug": "tmem86b" }, { "symbol": "PPP6R1", "ensemblId": "ENSG00000105063", "biotype": "protein_coding", "start": 55229776, "end": 55259070, "strand": "-", "slug": "ppp6r1" }, { "symbol": "HSPBP1", "ensemblId": "ENSG00000133265", "biotype": "protein_coding", "start": 55262219, "end": 55280930, "strand": "-", "slug": "hspbp1" }, { "symbol": "BRSK1", "ensemblId": "ENSG00000160469", "biotype": "protein_coding", "start": 55282072, "end": 55312592, "strand": "+", "slug": "brsk1" }, { "symbol": "TMEM150B", "ensemblId": "ENSG00000180061", "biotype": "protein_coding", "start": 55309440, "end": 55334048, "strand": "-", "slug": "tmem150b" }, { "symbol": "KMT5C", "ensemblId": "ENSG00000133247", "biotype": "protein_coding", "start": 55339367, "end": 55348122, "strand": "+", "slug": "kmt5c" }, { "symbol": "COX6B2", "ensemblId": "ENSG00000160471", "biotype": "protein_coding", "start": 55349306, "end": 55354754, "strand": "-", "slug": "cox6b2" }, { "symbol": "", "ensemblId": "ENSG00000267706", "biotype": "protein_coding", "start": 55352301, "end": 55359516, "strand": "-" }, { "symbol": "GARIN5B", "ensemblId": "ENSG00000180043", "biotype": "protein_coding", "start": 55354908, "end": 55363260, "strand": "-", "slug": "garin5b" }, { "symbol": "IL11", "ensemblId": "ENSG00000095752", "biotype": "protein_coding", "start": 55364382, "end": 55370463, "strand": "-", "slug": "il11" }, { "symbol": "TMEM190", "ensemblId": "ENSG00000160472", "biotype": "protein_coding", "start": 55376816, "end": 55378246, "strand": "+", "slug": "tmem190" }, { "symbol": "TMEM238", "ensemblId": "ENSG00000233493", "biotype": "protein_coding", "start": 55379244, "end": 55384305, "strand": "-", "slug": "tmem238" }, { "symbol": "RPL28", "ensemblId": "ENSG00000108107", "biotype": "protein_coding", "start": 55383856, "end": 55403342, "strand": "+", "slug": "rpl28" }, { "symbol": "UBE2S", "ensemblId": "ENSG00000108106", "biotype": "protein_coding", "start": 55385311, "end": 55408164, "strand": "-", "slug": "ube2s" }, { "symbol": "SHISA7", "ensemblId": "ENSG00000187902", "biotype": "protein_coding", "start": 55428740, "end": 55452900, "strand": "-", "slug": "shisa7" }, { "symbol": "ISOC2", "ensemblId": "ENSG00000063241", "biotype": "protein_coding", "start": 55452975, "end": 55462343, "strand": "-", "slug": "isoc2" }, { "symbol": "C19orf85", "ensemblId": "ENSG00000283567", "biotype": "protein_coding", "start": 55463001, "end": 55464752, "strand": "-", "slug": "c19orf85" }, { "symbol": "ZNF628", "ensemblId": "ENSG00000197483", "biotype": "protein_coding", "start": 55476597, "end": 55484487, "strand": "+", "slug": "znf628" }, { "symbol": "NAT14", "ensemblId": "ENSG00000090971", "biotype": "protein_coding", "start": 55484949, "end": 55487578, "strand": "+", "slug": "nat14" }, { "symbol": "SSC5D", "ensemblId": "ENSG00000179954", "biotype": "protein_coding", "start": 55488404, "end": 55519099, "strand": "+", "slug": "ssc5d" }, { "symbol": "SBK2", "ensemblId": "ENSG00000187550", "biotype": "protein_coding", "start": 55528607, "end": 55537143, "strand": "-", "slug": "sbk2" }, { "symbol": "SBK3", "ensemblId": "ENSG00000231274", "biotype": "protein_coding", "start": 55539018, "end": 55550284, "strand": "-", "slug": "sbk3" }, { "symbol": "ZNF579", "ensemblId": "ENSG00000218891", "biotype": "protein_coding", "start": 55576774, "end": 55580921, "strand": "-", "slug": "znf579" }, { "symbol": "FIZ1", "ensemblId": "ENSG00000179943", "biotype": "protein_coding", "start": 55591371, "end": 55606194, "strand": "-", "slug": "fiz1" }, { "symbol": "ZNF524", "ensemblId": "ENSG00000171443", "biotype": "protein_coding", "start": 55599714, "end": 55603592, "strand": "+", "slug": "znf524" }, { "symbol": "ZNF865", "ensemblId": "ENSG00000261221", "biotype": "protein_coding", "start": 55605502, "end": 55617269, "strand": "+", "slug": "znf865" }, { "symbol": "ZNF784", "ensemblId": "ENSG00000179922", "biotype": "protein_coding", "start": 55620741, "end": 55624570, "strand": "-", "slug": "znf784" }, { "symbol": "ZNF581", "ensemblId": "ENSG00000171425", "biotype": "protein_coding", "start": 55624664, "end": 55647294, "strand": "+", "slug": "znf581" }, { "symbol": "ZNF580", "ensemblId": "ENSG00000213015", "biotype": "protein_coding", "start": 55635003, "end": 55643470, "strand": "+", "slug": "znf580" }, { "symbol": "CCDC106", "ensemblId": "ENSG00000173581", "biotype": "protein_coding", "start": 55640967, "end": 55653161, "strand": "+", "slug": "ccdc106" }, { "symbol": "U2AF2", "ensemblId": "ENSG00000063244", "biotype": "protein_coding", "start": 55654115, "end": 55674717, "strand": "+", "slug": "u2af2" } ], "truncated": false }, "reports": [ { "slug": "dilated-cardiomyopathy", "name": "Dilatert kardiomyopati", "diseases": [ { "mondoId": "MONDO:0005021", "name": "Dilatert kardiomyopati", "genes": 50, "inheritance": null, "description": "Forstørrelse og svekkelse av venstre ventrikkel som ikke forklares av sykdom i kransarteriene eller hjerteklaffene. Arvelige former skyldes varianter i TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN og mange andre gener, og omfatter Barth syndrom og Emery-Dreifuss muskeldystrofi.", "management": "Kjennskap til en genetisk årsak støtter tidligere hjerteoppfølging og screening av familiemedlemmer. For gener med høy risiko for arytmi, som LMNA, FLNC og RBM20, er den til hjelp ved beslutninger om rytmeovervåking og implanterbare defibrillatorer.", "evidence": { "gencc": [ "Ambry Genetics", "ClinGen", "Labcorp Genetics (formerly Invitae)" ], "clingen": "Strong", "acmgSf": false, "inheritance": [ "autosomal-dominant", "autosomal-recessive" ] }, "sameAsReport": true, "broad": false } ], "url": "https://dantelabs.com/no/conditions/dilated-cardiomyopathy" }, { "slug": "restrictive-cardiomyopathy", "name": "Restriktiv kardiomyopati", "diseases": [ { "mondoId": "MONDO:0007270", "name": "Familiær restriktiv kardiomyopati 1 (TNNI3)", "genes": 1, "inheritance": "autosomal-dominant", "description": "En form for restriktiv kardiomyopati forårsaket av endringer i sarkomergenet TNNI3.", "management": "Kunnskap om dette støtter spesialistoppfølging av hjertet og screening av slektninger.", "evidence": { "gencc": [ "Labcorp Genetics (formerly Invitae)" ], "acmgSf": false, "inheritance": [ "autosomal-dominant" ] }, "sameAsReport": false, "broad": false } ], "url": "https://dantelabs.com/no/conditions/restrictive-cardiomyopathy" }, { "slug": "hypertrophic-cardiomyopathy", "name": "Hypertrofisk kardiomyopati", "diseases": [ { "mondoId": "MONDO:0005045", "name": "Hypertrofisk kardiomyopati", "genes": 62, "inheritance": "autosomal-dominant", "description": "En tilstand der hjertemuskelen er forstørret uten en åpenbar årsak. Forstørrelsen er vanligvis asymmetrisk og kan være assosiert med obstruksjon av utløpsveien fra hjertekammeret.", "management": "Betablokkere, ikke-dihydropyridin-kalsiumkanalblokkere, begrensning av aktivitet, genetisk veiledning", "evidence": { "gencc": [ "ClinGen", "G2P", "Labcorp Genetics (formerly Invitae)" ], "clingen": "Definitive", "acmgSf": true, "inheritance": [ "autosomal-dominant" ], "actionability": 10 }, "sameAsReport": true, "broad": true } ], "url": "https://dantelabs.com/no/conditions/hypertrophic-cardiomyopathy" } ], "pharmacogenomics": [], "traits": [], "phenotypes": [ { "slug": "arrhythmia", "name": "Abnormal heart rate", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/arrhythmia" }, { "slug": "abnormal-left-ventricular-function", "name": "Abnormal left ventricular function", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/abnormal-left-ventricular-function" }, { "slug": "apical-hypertrophic-cardiomyopathy", "name": "Apical hypertrophic cardiomyopathy", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/apical-hypertrophic-cardiomyopathy" }, { "slug": "dyspnea", "name": "Breathing difficulty", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/dyspnea" }, { "slug": "congestive-heart-failure", "name": "Cardiac failure", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/congestive-heart-failure" }, { "slug": "cardiomyocyte-hypertrophy", "name": "Cardiomyocyte hypertrophy", "systems": [ "abnormal-cellular-phenotype", "abnormality-of-the-cardiovascular-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/cardiomyocyte-hypertrophy" }, { "slug": "emg-abnormality", "name": "EMG abnormality", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/emg-abnormality" }, { "slug": "hypertrophic-cardiomyopathy", "name": "Enlarged and thickened heart muscle", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/hypertrophic-cardiomyopathy" }, { "slug": "hepatomegaly", "name": "Enlarged liver", "systems": [ "abnormality-of-the-digestive-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/hepatomegaly" }, { "slug": "pulmonary-edema", "name": "Excess fluid in lungs", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/pulmonary-edema" }, { "slug": "exertional-dyspnea", "name": "Exertional breathlessness", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/exertional-dyspnea" }, { "slug": "syncope", "name": "Fainting spell", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-nervous-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/syncope" }, { "slug": "fatigue", "name": "Fatigue", "systems": [ "constitutional-symptom" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/fatigue" }, { "slug": "edema", "name": "Fluid retention", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/edema" }, { "slug": "postnatal-growth-retardation", "name": "Growth delay as children", "systems": [ "growth-abnormality" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/postnatal-growth-retardation" }, { "slug": "increased-left-ventricular-end-diastolic-volume", "name": "Increased left ventricular end-diastolic volume", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/increased-left-ventricular-end-diastolic-volume" }, { "slug": "interstitial-cardiac-fibrosis", "name": "Interstitial cardiac fibrosis", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/interstitial-cardiac-fibrosis" }, { "slug": "left-atrial-enlargement", "name": "Left atrial enlargement", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/left-atrial-enlargement" }, { "slug": "left-ventricular-hypertrophy", "name": "Left ventricular hypertrophy", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/left-ventricular-hypertrophy" }, { "slug": "left-ventricular-systolic-dysfunction", "name": "Left ventricular systolic dysfunction", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/left-ventricular-systolic-dysfunction" }, { "slug": "lipoatrophy", "name": "Loss of fat tissue in localized area", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/lipoatrophy" }, { "slug": "mitral-regurgitation", "name": "Mitral regurgitation", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/mitral-regurgitation" }, { "slug": "myopathy", "name": "Muscle tissue disease", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/myopathy" }, { "slug": "orthopnea", "name": "Orthopnea", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/orthopnea" }, { "slug": "peripheral-edema", "name": "Peripheral edema", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/peripheral-edema" }, { "slug": "pulmonary-venous-hypertension", "name": "Pulmonary venous hypertension", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-respiratory-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/pulmonary-venous-hypertension" }, { "slug": "atrial-fibrillation", "name": "Quivering upper heart chambers resulting in irregular heartbeat", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/atrial-fibrillation" }, { "slug": "recurrent-respiratory-infections", "name": "Recurrent respiratory infections", "systems": [ "abnormality-of-the-immune-system", "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/recurrent-respiratory-infections" }, { "slug": "restrictive-cardiomyopathy", "name": "Restrictive cardiomyopathy", "systems": [ "abnormality-of-the-cardiovascular-system" ], "url": "https://dantelabs.com/traits/restrictive-cardiomyopathy" }, { "slug": "right-atrial-enlargement", "name": "Right atrial enlargement", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/right-atrial-enlargement" }, { "slug": "sensorineural-hearing-impairment", "name": "Sensorineural hearing impairment", "systems": [ "abnormality-of-the-ear" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment" }, { "slug": "severely-reduced-left-ventricular-ejection-fraction", "name": "Severely reduced left ventricular ejection fraction", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/severely-reduced-left-ventricular-ejection-fraction" }, { "slug": "dilated-cardiomyopathy", "name": "Stretched and thinned heart muscle", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/dilated-cardiomyopathy" }, { "slug": "stroke", "name": "Stroke", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-nervous-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/stroke" }, { "slug": "sudden-cardiac-death", "name": "Sudden cardiac death", "systems": [ "abnormality-of-the-cardiovascular-system", "constitutional-symptom" ], "url": "https://dantelabs.com/traits/sudden-cardiac-death" }, { "slug": "supraventricular-arrhythmia", "name": "Supraventricular arrhythmia", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/supraventricular-arrhythmia" }, { "slug": "thromboembolic-stroke", "name": "Thromboembolic stroke", "systems": [ "abnormality-of-blood-and-blood-forming-tissues" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/thromboembolic-stroke" }, { "slug": "thromboembolism", "name": "Thromboembolism", "systems": [ "abnormality-of-blood-and-blood-forming-tissues" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/thromboembolism" }, { "slug": "tricuspid-regurgitation", "name": "Tricuspid regurgitation", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/tricuspid-regurgitation" }, { "slug": "ventricular-hypertrophy", "name": "Ventricular hypertrophy", "systems": [ "abnormality-of-the-cardiovascular-system" ], "url": "https://dantelabs.com/traits/ventricular-hypertrophy" }, { "slug": "ventriculomegaly", "name": "Ventriculomegaly", "systems": [ "abnormality-of-the-nervous-system" ], "url": "https://dantelabs.com/traits/ventriculomegaly" }, { "slug": "wolff-parkinson-white-syndrome", "name": "Wolff-Parkinson-White syndrome", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/wolff-parkinson-white-syndrome" } ], "related": [ { "slug": "actc1", "symbol": "ACTC1", "name": "actin alpha cardiac muscle 1", "shared": 2, "url": "https://dantelabs.com/no/genes/actc1" }, { "slug": "flnc", "symbol": "FLNC", "name": "filamin C", "shared": 2, "url": "https://dantelabs.com/no/genes/flnc" }, { "slug": "jph2", "symbol": "JPH2", "name": "junctophilin 2", "shared": 2, "url": "https://dantelabs.com/no/genes/jph2" }, { "slug": "ldb3", "symbol": "LDB3", "name": "LIM domain binding 3", "shared": 2, "url": "https://dantelabs.com/no/genes/ldb3" }, { "slug": "mybpc3", "symbol": "MYBPC3", "name": "myosin binding protein C3", "shared": 2, "url": "https://dantelabs.com/no/genes/mybpc3" }, { "slug": "myh7", "symbol": "MYH7", "name": "myosin heavy chain 7", "shared": 2, "url": "https://dantelabs.com/no/genes/myh7" }, { "slug": "mypn", "symbol": "MYPN", "name": "myopalladin", "shared": 2, "url": "https://dantelabs.com/no/genes/mypn" }, { "slug": "pln", "symbol": "PLN", "name": "phospholamban", "shared": 2, "url": "https://dantelabs.com/no/genes/pln" }, { "slug": "raf1", "symbol": "RAF1", "name": "Raf-1 proto-oncogene, serine/threonine kinase", "shared": 2, "url": "https://dantelabs.com/no/genes/raf1" }, { "slug": "tcap", "symbol": "TCAP", "name": "titin-cap", "shared": 2, "url": "https://dantelabs.com/no/genes/tcap" }, { "slug": "tnnc1", "symbol": "TNNC1", "name": "troponin C1, slow skeletal and cardiac type", "shared": 2, "url": "https://dantelabs.com/no/genes/tnnc1" }, { "slug": "tnnt2", "symbol": "TNNT2", "name": "troponin T2, cardiac type", "shared": 2, "url": "https://dantelabs.com/no/genes/tnnt2" } ], "sources": { "bundleId": "2026.10.17-8666dff2", "panel": "2026-10-17", "acmgSf": "SF v3.2" }, "locusKind": "proteinCoding" }, "variants": { "total": 18, "url": "https://dantelabs.com/genes/tnni3/variants", "items": [ { "slug": "r162q", "name": "R162Q", 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