{
  "url": "https://dantelabs.com/no/genes/serpinc1",
  "gene": {
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    "reports": [
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        "slug": "thrombophilia",
        "name": "Trombofili",
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          {
            "mondoId": "MONDO:0100240",
            "name": "Arvelig trombofili",
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            "inheritance": null,
            "description": null,
            "management": "Antikoagulasjon (varighet etter genotype); unngå østrogenholdige prevensjonsmidler; LMWH ved graviditetsprofylakse; forlenget antikoagulasjon etter kirurgi; livslang antikoagulasjon ved sammensatte/høyrisikogenotyper",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
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              "clingen": "Definitive",
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              "inheritance": [
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        "url": "https://dantelabs.com/no/conditions/thrombophilia"
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    "pharmacogenomics": [],
    "traits": [],
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        "slug": "arterial-occlusion",
        "name": "Arterial occlusion",
        "systems": [
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        "url": "https://dantelabs.com/traits/arterial-occlusion"
      },
      {
        "slug": "deep-venous-thrombosis",
        "name": "Blood clot in a deep vein",
        "systems": [
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/deep-venous-thrombosis"
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      {
        "slug": "arterial-thrombosis",
        "name": "Blood clot in artery",
        "systems": [
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arterial-thrombosis"
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      {
        "slug": "pulmonary-embolism",
        "name": "Blood clot in artery of lung",
        "systems": [
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pulmonary-embolism"
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      {
        "slug": "cerebral-venous-thrombosis",
        "name": "Blood clot in cerebral vein",
        "systems": [
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        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/cerebral-venous-thrombosis"
      },
      {
        "slug": "hepatic-vein-thrombosis",
        "name": "Blood clot in liver vein",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hepatic-vein-thrombosis"
      },
      {
        "slug": "portal-vein-thrombosis",
        "name": "Blood clot in portal vein",
        "systems": [
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          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/portal-vein-thrombosis"
      },
      {
        "slug": "decreased-level-of-heparin-co-factor-ii",
        "name": "Decreased level of heparin co-factor II",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
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        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-level-of-heparin-co-factor-ii"
      },
      {
        "slug": "mesenteric-venous-thrombosis",
        "name": "Mesenteric venous thrombosis",
        "systems": [
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/mesenteric-venous-thrombosis"
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      {
        "slug": "recurrent-thromboembolism",
        "name": "Recurrent thromboembolism",
        "systems": [
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-thromboembolism"
      },
      {
        "slug": "recurrent-thrombophlebitis",
        "name": "Recurrent thrombophlebitis",
        "systems": [
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        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-thrombophlebitis"
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      {
        "slug": "reduced-antithrombin-antigen",
        "name": "Reduced antithrombin antigen",
        "systems": [
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        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/reduced-antithrombin-antigen"
      },
      {
        "slug": "reduced-antithrombin-iii-activity",
        "name": "Reduced antithrombin III activity",
        "systems": [
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        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/reduced-antithrombin-iii-activity"
      },
      {
        "slug": "retinal-venous-occlusion",
        "name": "Retinal venous occlusion",
        "systems": [
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          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retinal-venous-occlusion"
      },
      {
        "slug": "superficial-thrombophlebitis",
        "name": "Superficial thrombophlebitis",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/superficial-thrombophlebitis"
      }
    ],
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      {
        "slug": "f2",
        "symbol": "F2",
        "name": "coagulation factor II, thrombin",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/f2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "name": "coagulation factor V",
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        "url": "https://dantelabs.com/no/genes/f5"
      },
      {
        "slug": "f9",
        "symbol": "F9",
        "name": "coagulation factor IX",
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        "url": "https://dantelabs.com/no/genes/f9"
      },
      {
        "slug": "hrg",
        "symbol": "HRG",
        "name": "histidine rich glycoprotein",
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        "url": "https://dantelabs.com/no/genes/hrg"
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      {
        "slug": "proc",
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        "name": "protein C, inactivator of coagulation factors Va and VIIIa",
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        "url": "https://dantelabs.com/no/genes/proc"
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        "url": "https://dantelabs.com/no/genes/pros1"
      },
      {
        "slug": "serpind1",
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        "name": "serpin family D member 1",
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        "url": "https://dantelabs.com/no/genes/serpind1"
      },
      {
        "slug": "thbd",
        "symbol": "THBD",
        "name": "thrombomodulin",
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        "url": "https://dantelabs.com/no/genes/thbd"
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      "panel": "2026-10-17",
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    "locusKind": "proteinCoding"
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    "url": "https://dantelabs.com/genes/serpinc1/variants",
    "items": [
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        "url": "https://dantelabs.com/genes/serpinc1/variants/k139-f140del"
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        "url": "https://dantelabs.com/genes/serpinc1/variants/k260x"
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      {
        "slug": "l131f",
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        "symbol": "SERPINC1",
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        "url": "https://dantelabs.com/genes/serpinc1/variants/l131f"
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      {
        "slug": "n219d",
        "name": "N219D",
        "commonName": null,
        "symbol": "SERPINC1",
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        "url": "https://dantelabs.com/genes/serpinc1/variants/n219d"
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      {
        "slug": "n437k",
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        "commonName": null,
        "symbol": "SERPINC1",
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        "url": "https://dantelabs.com/genes/serpinc1/variants/n437k"
      },
      {
        "slug": "p73l",
        "name": "P73L",
        "commonName": null,
        "symbol": "SERPINC1",
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        "hgvsC": "c.218C>T",
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        "url": "https://dantelabs.com/genes/serpinc1/variants/p73l"
      },
      {
        "slug": "p318l",
        "name": "P318L",
        "commonName": null,
        "symbol": "SERPINC1",
        "classification": "pathogenic",
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