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"https://dantelabs.com/traits/exercise-intolerance" }, { "slug": "elevated-circulating-creatine-kinase-activity", "name": "Elevated blood creatine phosphokinase", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/elevated-circulating-creatine-kinase-activity" }, { "slug": "tachycardia", "name": "Elevated heart rate", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/tachycardia" }, { "slug": "hypertrophic-cardiomyopathy", "name": "Enlarged and thickened heart muscle", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/hypertrophic-cardiomyopathy" }, { "slug": "exercise-induced-muscle-cramps", "name": "Exercise-induced muscle cramps", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/exercise-induced-muscle-cramps" }, { "slug": "exercise-induced-myalgia", "name": "Exercise-induced muscle pain", "systems": [ "constitutional-symptom" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/exercise-induced-myalgia" }, { "slug": "exercise-induced-muscle-stiffness", "name": "Exercise-induced muscle stiffness", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/exercise-induced-muscle-stiffness" }, { "slug": "exercise-induced-myoglobinuria", "name": "Exercise-induced myoglobinuria", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/exercise-induced-myoglobinuria" }, { "slug": "exercise-induced-rhabdomyolysis", "name": "Exercise-induced rhabdomyolysis", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "url": "https://dantelabs.com/traits/exercise-induced-rhabdomyolysis" }, { "slug": "exertional-dyspnea", "name": "Exertional breathlessness", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/exertional-dyspnea" }, { "slug": "failure-to-elevate-ammonia-on-ischemic-exercise", "name": "Failure to elevate ammonia on ischemic exercise", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/failure-to-elevate-ammonia-on-ischemic-exercise" }, { "slug": "failure-to-elevate-lactate-upon-ischemic-exercise-test", "name": "Failure to elevate lactate upon ischemic exercise test", "systems": [ "abnormality-of-metabolism-homeostasis" ], "url": "https://dantelabs.com/traits/failure-to-elevate-lactate-upon-ischemic-exercise-test" }, { "slug": "fatigue", "name": "Fatigue", "systems": [ "constitutional-symptom" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/fatigue" }, { "slug": "glycogen-accumulation-in-muscle-fiber-lysosomes", "name": "Glycogen accumulation in muscle fiber lysosomes", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-musculoskeletal-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/glycogen-accumulation-in-muscle-fiber-lysosomes" }, { "slug": "hyperuricemia", "name": "High blood uric acid level", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hyperuricemia" }, { "slug": "highly-elevated-creatine-kinase", "name": "Highly elevated creatine kinase", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/highly-elevated-creatine-kinase" }, { "slug": "increased-muscle-glycogen-content", "name": "Increased muscle glycogen content", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-musculoskeletal-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/increased-muscle-glycogen-content" }, { "slug": "skeletal-muscle-atrophy", "name": "Muscle degeneration", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/skeletal-muscle-atrophy" }, { "slug": "muscle-weakness", "name": "Muscle weakness", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/muscle-weakness" }, { "slug": "myoglobinuria", "name": "Myoglobinuria", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/myoglobinuria" }, { "slug": "dysphagia", "name": "Poor swallowing", "systems": [ "abnormality-of-the-digestive-system", "abnormality-of-the-nervous-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/dysphagia" }, { "slug": "postexertional-symptom-exacerbation", "name": "Postexertional symptom exacerbation", "systems": [ "constitutional-symptom" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/postexertional-symptom-exacerbation" }, { "slug": "progressive-proximal-muscle-weakness", "name": "Progressive proximal muscle weakness", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/progressive-proximal-muscle-weakness" }, { "slug": "recurrent-myoglobinuria", "name": "Recurrent myoglobinuria", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/recurrent-myoglobinuria" }, { "slug": "reduced-muscle-glycogen-phosphorylase-activity", "name": "Reduced muscle glycogen phosphorylase activity", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/reduced-muscle-glycogen-phosphorylase-activity" } ], "related": [], "sources": { "bundleId": "2026.10.17-8666dff2", "panel": "2026-10-17", "acmgSf": "SF v3.2" }, "locusKind": "proteinCoding" }, "variants": { "total": 0, "url": null, "items": [] } }