{
  "url": "https://dantelabs.com/no/genes/onecut1",
  "gene": {
    "slug": "onecut1",
    "symbol": "ONECUT1",
    "name": "one cut homeobox 1",
    "hgnc": "HGNC:8138",
    "summary": null,
    "location": "15q21.3",
    "locusType": "gene with protein product",
    "aliases": [
      "HNF-6"
    ],
    "previousSymbols": [
      "HNF6",
      "HNF6A"
    ],
    "ensemblId": "ENSG00000169856",
    "entrezId": 3175,
    "omim": [
      "604164"
    ],
    "uniprot": [
      "Q9UBC0"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "15",
      "start": 52755053,
      "end": 52790336,
      "strand": "-",
      "ensemblTranscript": "ENST00000305901.7",
      "refseqTranscript": "NM_004498.4",
      "ensemblProtein": "ENSP00000302630.4",
      "refseqProtein": "NP_004489.1",
      "exons": [
        {
          "start": 52755053,
          "end": 52757847
        },
        {
          "start": 52788780,
          "end": 52790336
        }
      ],
      "cds": {
        "start": 52757555,
        "end": 52789884
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "15",
      "start": 53049637,
      "end": 53083273,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 52272695,
      "end": 53272694,
      "genes": [
        {
          "symbol": "MYO5C",
          "ensemblId": "ENSG00000128833",
          "biotype": "protein_coding",
          "start": 52192309,
          "end": 52295815,
          "strand": "-",
          "slug": "myo5c"
        },
        {
          "symbol": "MYO5A",
          "ensemblId": "ENSG00000197535",
          "biotype": "protein_coding",
          "start": 52307281,
          "end": 52529248,
          "strand": "-",
          "slug": "myo5a"
        },
        {
          "symbol": "ARPP19",
          "ensemblId": "ENSG00000128989",
          "biotype": "protein_coding",
          "start": 52547045,
          "end": 52569883,
          "strand": "-",
          "slug": "arpp19"
        },
        {
          "symbol": "ATOSA",
          "ensemblId": "ENSG00000047346",
          "biotype": "protein_coding",
          "start": 52581317,
          "end": 52709824,
          "strand": "-",
          "slug": "atosa"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "diabetes-mellitus",
        "name": "Diabetes mellitus",
        "diseases": [
          {
            "mondoId": "MONDO:0005015",
            "name": "Diabetes mellitus",
            "genes": 31,
            "inheritance": null,
            "description": "En metabolsk sykdom preget av unormalt høye blodsukkerverdier på grunn av redusert insulinproduksjon eller insulinresistens/desensitisering.",
            "management": "Teplizumab (Tzield) ved presymptomatisk T1D i stadium 2 (godkjent av FDA 2022); insulinerstatning ved klinisk debut av T1D; TrialNet-screening for autoantistoffer hos slektninger med høy risiko; closed-loop-systemer for insulinlevering",
            "evidence": {
              "gencc": [
                "G2P",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/diabetes-mellitus"
      },
      {
        "slug": "neonatal-diabetes-mellitus",
        "name": "Neonatal diabetes mellitus",
        "diseases": [
          {
            "mondoId": "MONDO:0016391",
            "name": "Neonatal diabetes mellitus",
            "genes": 20,
            "inheritance": null,
            "description": "Diabetes som oppdages i løpet av de første månedene av livet, enten permanent eller forbigående, forårsaket av enkeltgenfeil i insulinproduksjon eller insulinsekresjon.",
            "management": "De fleste med KCNJ11- eller ABCC8-relatert neonatal diabetes kan gå fra insulininjeksjoner til sulfonylureatabletter, ofte med bedre blodsukkerkontroll.",
            "evidence": {
              "gencc": [
                "G2P",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/neonatal-diabetes-mellitus"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [],
    "related": [
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "name": "ATP binding cassette subfamily C member 8",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/abcc8"
      },
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/bscl2"
      },
      {
        "slug": "eif2b1",
        "symbol": "EIF2B1",
        "name": "eukaryotic translation initiation factor 2B subunit alpha",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/eif2b1"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "name": "GATA binding protein 4",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/gata4"
      },
      {
        "slug": "gata6",
        "symbol": "GATA6",
        "name": "GATA binding protein 6",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/gata6"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "name": "glucokinase",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/gck"
      },
      {
        "slug": "glis3",
        "symbol": "GLIS3",
        "name": "GLIS family zinc finger 3",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/glis3"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "name": "HNF1 homeobox B",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/hnf1b"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "name": "interleukin 2 receptor subunit alpha",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/il2ra"
      },
      {
        "slug": "ins",
        "symbol": "INS",
        "name": "insulin",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/ins"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/kcnj11"
      },
      {
        "slug": "mnx1",
        "symbol": "MNX1",
        "name": "motor neuron and pancreas homeobox 1",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/mnx1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}