{
  "url": "https://dantelabs.com/no/genes/nlgn4x",
  "gene": {
    "slug": "nlgn4x",
    "symbol": "NLGN4X",
    "name": "neuroligin 4 X-linked",
    "hgnc": "HGNC:14287",
    "summary": null,
    "location": "Xp22.32-p22.31",
    "locusType": "gene with protein product",
    "aliases": [
      "KIAA1260",
      "NLGN",
      "HLNX"
    ],
    "previousSymbols": [
      "NLGN4"
    ],
    "ensemblId": "ENSG00000146938",
    "entrezId": 57502,
    "omim": [
      "300427"
    ],
    "uniprot": [
      "Q8N0W4"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "X",
      "start": 5890042,
      "end": 6228867,
      "strand": "-",
      "ensemblTranscript": "ENST00000381095.8",
      "refseqTranscript": "NM_181332.3",
      "ensemblProtein": "ENSP00000370485.3",
      "refseqProtein": "NP_851849.1",
      "exons": [
        {
          "start": 5890042,
          "end": 5893666
        },
        {
          "start": 5903077,
          "end": 5903866
        },
        {
          "start": 5909054,
          "end": 5909239
        },
        {
          "start": 6029280,
          "end": 6029432
        },
        {
          "start": 6150995,
          "end": 6151771
        },
        {
          "start": 6228541,
          "end": 6228867
        }
      ],
      "cds": {
        "start": 5892817,
        "end": 6151466
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "X",
      "start": 5758678,
      "end": 6146904,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 5551216,
      "end": 6567693,
      "genes": [
        {
          "symbol": "VCX3A",
          "ensemblId": "ENSG00000169059",
          "biotype": "protein_coding",
          "start": 6533618,
          "end": 6535118,
          "strand": "-",
          "slug": "vcx3a"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "autism-spectrum-disorder",
        "name": "Autismespektrumforstyrrelse",
        "diseases": [
          {
            "mondoId": "MONDO:0020836",
            "name": "Autisme, mottakelighet for (enkeltgen-former)",
            "genes": 6,
            "inheritance": null,
            "description": "Enkeltgeners bidrag til autisme, inkludert varianter i NLGN3, NLGN4X, PTCHD1, SHANK2, TBR1 og CHD8.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/autism-spectrum-disorder"
      },
      {
        "slug": "epilepsy-report",
        "name": "Epilepsi (fullstendig panel)",
        "diseases": [
          {
            "mondoId": "MONDO:0100148",
            "name": "X-bundet kompleks nevroutviklingsforstyrrelse",
            "genes": 25,
            "inheritance": null,
            "description": "En kompleks nevroutviklingsforstyrrelse som arves X-bundet, og som kjennetegnes av intellektuell funksjonsnedsettelse, autisme og epilepsi.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/epilepsy-report"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "plagiocephaly",
        "name": "Asymmetry of the posterior head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/plagiocephaly"
      },
      {
        "slug": "autism",
        "name": "Autism",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/autism"
      },
      {
        "slug": "autistic-behavior",
        "name": "Autism spectrum disorder",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/autistic-behavior"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "eeg-abnormality",
        "name": "EEG abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/eeg-abnormality"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "abnormal-nonverbal-communicative-behavior",
        "name": "Impaired use of nonverbal behaviors",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-nonverbal-communicative-behavior"
      },
      {
        "slug": "increased-serum-serotonin",
        "name": "Increased serum serotonin",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-serum-serotonin"
      },
      {
        "slug": "inflexible-adherence-to-routines",
        "name": "Inflexible adherence to routines",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/inflexible-adherence-to-routines"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "mild-intellectual-disability",
        "name": "Intellectual disability, mild",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/mild-intellectual-disability"
      },
      {
        "slug": "lack-of-peer-relationships",
        "name": "Lack of peer relationships",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/lack-of-peer-relationships"
      },
      {
        "slug": "lack-of-spontaneous-play",
        "name": "Lack of spontaneous play",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/lack-of-spontaneous-play"
      },
      {
        "slug": "reduced-ability-to-form-peer-relationships",
        "name": "Reduced ability to form peer relationships",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/reduced-ability-to-form-peer-relationships"
      },
      {
        "slug": "motor-stereotypy",
        "name": "Repetitive movements",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/motor-stereotypy"
      },
      {
        "slug": "restrictive-behavior",
        "name": "Restrictive behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/restrictive-behavior"
      }
    ],
    "related": [
      {
        "slug": "nlgn3",
        "symbol": "NLGN3",
        "name": "neuroligin 3",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/nlgn3"
      },
      {
        "slug": "ptchd1",
        "symbol": "PTCHD1",
        "name": "patched domain containing 1",
        "shared": 2,
        "url": "https://dantelabs.com/no/genes/ptchd1"
      },
      {
        "slug": "arhgef9",
        "symbol": "ARHGEF9",
        "name": "Cdc42 guanine nucleotide exchange factor 9",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/arhgef9"
      },
      {
        "slug": "arx",
        "symbol": "ARX",
        "name": "aristaless related homeobox",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/arx"
      },
      {
        "slug": "chd8",
        "symbol": "CHD8",
        "name": "chromodomain helicase DNA binding protein 8",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/chd8"
      },
      {
        "slug": "clcn4",
        "symbol": "CLCN4",
        "name": "Cl-/H+ antiporter 4",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/clcn4"
      },
      {
        "slug": "cnksr2",
        "symbol": "CNKSR2",
        "name": "connector enhancer of kinase suppressor of Ras 2",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/cnksr2"
      },
      {
        "slug": "frmpd4",
        "symbol": "FRMPD4",
        "name": "FERM and PDZ domain containing 4",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/frmpd4"
      },
      {
        "slug": "ftsj1",
        "symbol": "FTSJ1",
        "name": "FtsJ RNA 2'-O-methyltransferase 1",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/ftsj1"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/gria3"
      },
      {
        "slug": "hnrnph2",
        "symbol": "HNRNPH2",
        "name": "heterogeneous nuclear ribonucleoprotein H2",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/hnrnph2"
      },
      {
        "slug": "il1rapl1",
        "symbol": "IL1RAPL1",
        "name": "interleukin 1 receptor accessory protein like 1",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/il1rapl1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-8b139e39",
      "panel": "2026-10-18",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}