{
  "url": "https://dantelabs.com/no/genes/flt4",
  "gene": {
    "slug": "flt4",
    "symbol": "FLT4",
    "name": "fms related receptor tyrosine kinase 4",
    "hgnc": "HGNC:3767",
    "summary": null,
    "location": "5q35.3",
    "locusType": "gene with protein product",
    "aliases": [
      "VEGFR3",
      "PCL",
      "VEGFR-3"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000037280",
    "entrezId": 2324,
    "omim": [
      "136352"
    ],
    "uniprot": [
      "P35916"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "5",
      "start": 180601506,
      "end": 180649600,
      "strand": "-",
      "ensemblTranscript": "ENST00000261937.11",
      "refseqTranscript": "NM_182925.5",
      "ensemblProtein": "ENSP00000261937.6",
      "refseqProtein": "NP_891555.2",
      "exons": [
        {
          "start": 180601506,
          "end": 180603390
        },
        {
          "start": 180608968,
          "end": 180609053
        },
        {
          "start": 180609905,
          "end": 180610025
        },
        {
          "start": 180611331,
          "end": 180611479
        },
        {
          "start": 180612506,
          "end": 180612611
        },
        {
          "start": 180613011,
          "end": 180613110
        },
        {
          "start": 180614068,
          "end": 180614179
        },
        {
          "start": 180616367,
          "end": 180616489
        },
        {
          "start": 180616900,
          "end": 180616994
        },
        {
          "start": 180618770,
          "end": 180618920
        },
        {
          "start": 180619021,
          "end": 180619109
        },
        {
          "start": 180619253,
          "end": 180619366
        },
        {
          "start": 180619665,
          "end": 180619769
        },
        {
          "start": 180620173,
          "end": 180620308
        },
        {
          "start": 180620609,
          "end": 180620715
        },
        {
          "start": 180620876,
          "end": 180621007
        },
        {
          "start": 180621106,
          "end": 180621252
        },
        {
          "start": 180621542,
          "end": 180621904
        },
        {
          "start": 180622731,
          "end": 180622839
        },
        {
          "start": 180623935,
          "end": 180624061
        },
        {
          "start": 180625869,
          "end": 180626031
        },
        {
          "start": 180626111,
          "end": 180626265
        },
        {
          "start": 180628882,
          "end": 180628999
        },
        {
          "start": 180629259,
          "end": 180629427
        },
        {
          "start": 180629696,
          "end": 180629835
        },
        {
          "start": 180629943,
          "end": 180630105
        },
        {
          "start": 180630225,
          "end": 180630337
        },
        {
          "start": 180630555,
          "end": 180630799
        },
        {
          "start": 180631682,
          "end": 180631778
        },
        {
          "start": 180649488,
          "end": 180649600
        }
      ],
      "cds": {
        "start": 180603192,
        "end": 180649545
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "5",
      "start": 180028506,
      "end": 180076624,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 180125553,
      "end": 181125552,
      "genes": [
        {
          "symbol": "RASGEF1C",
          "ensemblId": "ENSG00000146090",
          "biotype": "protein_coding",
          "start": 180100795,
          "end": 180209225,
          "strand": "-",
          "slug": "rasgef1c"
        },
        {
          "symbol": "MAPK9",
          "ensemblId": "ENSG00000050748",
          "biotype": "protein_coding",
          "start": 180233143,
          "end": 180292107,
          "strand": "-",
          "slug": "mapk9"
        },
        {
          "symbol": "GFPT2",
          "ensemblId": "ENSG00000131459",
          "biotype": "protein_coding",
          "start": 180300668,
          "end": 180353359,
          "strand": "-",
          "slug": "gfpt2"
        },
        {
          "symbol": "CNOT6",
          "ensemblId": "ENSG00000113300",
          "biotype": "protein_coding",
          "start": 180494334,
          "end": 180578404,
          "strand": "+",
          "slug": "cnot6"
        },
        {
          "symbol": "SCGB3A1",
          "ensemblId": "ENSG00000161055",
          "biotype": "protein_coding",
          "start": 180590105,
          "end": 180591706,
          "strand": "-",
          "slug": "scgb3a1"
        },
        {
          "symbol": "OR2Y1",
          "ensemblId": "ENSG00000174339",
          "biotype": "protein_coding",
          "start": 180739123,
          "end": 180740058,
          "strand": "-",
          "slug": "or2y1"
        },
        {
          "symbol": "MGAT1",
          "ensemblId": "ENSG00000131446",
          "biotype": "protein_coding",
          "start": 180784780,
          "end": 180815652,
          "strand": "-",
          "slug": "mgat1"
        },
        {
          "symbol": "ZFP62",
          "ensemblId": "ENSG00000196670",
          "biotype": "protein_coding",
          "start": 180843577,
          "end": 180861285,
          "strand": "-",
          "slug": "zfp62"
        },
        {
          "symbol": "BTNL8",
          "ensemblId": "ENSG00000113303",
          "biotype": "protein_coding",
          "start": 180899077,
          "end": 180952175,
          "strand": "+",
          "slug": "btnl8"
        },
        {
          "symbol": "BTNL3",
          "ensemblId": "ENSG00000168903",
          "biotype": "protein_coding",
          "start": 180988846,
          "end": 181006727,
          "strand": "+",
          "slug": "btnl3"
        },
        {
          "symbol": "BTNL9",
          "ensemblId": "ENSG00000165810",
          "biotype": "protein_coding",
          "start": 181040224,
          "end": 181061916,
          "strand": "+",
          "slug": "btnl9"
        },
        {
          "symbol": "OR2V1",
          "ensemblId": "ENSG00000185372",
          "biotype": "protein_coding",
          "start": 181123122,
          "end": 181131169,
          "strand": "-",
          "slug": "or2v1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "primary-lymphoedema-lymphatic-malformations",
        "name": "Primær lymfødem og lymfatiske malformasjoner",
        "diseases": [
          {
            "mondoId": "MONDO:0007919",
            "name": "Milroys sykdom (lymfatisk malformasjon 1)",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "Hevelse i underben og føtter fra fødselen eller tidlig i barndommen, forårsaket av endringer i FLT4.",
            "management": "Å vite om tilstanden bidrar til tidlig kompresjonsbehandling, god hudpleie og rask behandling av infeksjoner.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/primary-lymphoedema-lymphatic-malformations"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-facial-shape",
        "name": "Abnormal facial shape",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormal-facial-shape"
      },
      {
        "slug": "abnormal-nasal-morphology",
        "name": "Abnormal of nasal shape",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-nasal-morphology"
      },
      {
        "slug": "toenail-dysplasia",
        "name": "Abnormal toenail development",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/toenail-dysplasia"
      },
      {
        "slug": "abnormal-venous-morphology",
        "name": "Abnormal vein",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-venous-morphology"
      },
      {
        "slug": "absence-of-the-pulmonary-valve",
        "name": "Absence of the pulmonary valve",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/absence-of-the-pulmonary-valve"
      },
      {
        "slug": "angiosarcoma",
        "name": "Angiosarcoma",
        "systems": [
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/angiosarcoma"
      },
      {
        "slug": "ankle-swelling",
        "name": "Ankle swelling",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ankle-swelling"
      },
      {
        "slug": "anxiety",
        "name": "Anxiety",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anxiety"
      },
      {
        "slug": "aortopulmonary-collateral-arteries",
        "name": "Aortopulmonary collateral arteries",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/aortopulmonary-collateral-arteries"
      },
      {
        "slug": "cellulitis",
        "name": "Bacterial infection of skin",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cellulitis"
      },
      {
        "slug": "atypical-behavior",
        "name": "Behavioral abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atypical-behavior"
      },
      {
        "slug": "broad-forehead",
        "name": "Broad forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/broad-forehead"
      },
      {
        "slug": "proptosis",
        "name": "Bulging eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/proptosis"
      },
      {
        "slug": "clinodactyly-of-the-5th-finger",
        "name": "Curvature of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-finger"
      },
      {
        "slug": "thin-vermilion-border",
        "name": "Decreased volume of lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thin-vermilion-border"
      },
      {
        "slug": "depression",
        "name": "Depression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/depression"
      },
      {
        "slug": "double-aortic-arch",
        "name": "Double aortic arch",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/double-aortic-arch"
      },
      {
        "slug": "erysipelas",
        "name": "Erysipelas",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/erysipelas"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "underdeveloped-supraorbital-ridges",
        "name": "Flattened bony protrusion above eyes",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/underdeveloped-supraorbital-ridges"
      },
      {
        "slug": "pedal-edema",
        "name": "Fluid accumulation in lower limbs",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pedal-edema"
      },
      {
        "slug": "hydrocele-testis",
        "name": "Hydrocele testis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hydrocele-testis"
      },
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      },
      {
        "slug": "hyperkeratosis-over-edematous-areas",
        "name": "Hyperkeratosis over edematous areas",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/hyperkeratosis-over-edematous-areas"
      },
      {
        "slug": "lichenification",
        "name": "Lichenification",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lichenification"
      },
      {
        "slug": "dolichocephaly",
        "name": "Long, narrow head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dolichocephaly"
      },
      {
        "slug": "pulmonic-stenosis",
        "name": "Narrowing of pulmonic valve",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/pulmonic-stenosis"
      },
      {
        "slug": "nonimmune-hydrops-fetalis",
        "name": "Nonimmune hydrops fetalis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/nonimmune-hydrops-fetalis"
      },
      {
        "slug": "papilloma",
        "name": "Papilloma",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/papilloma"
      },
      {
        "slug": "preauricular-pit",
        "name": "Pit in front of the ear",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/preauricular-pit"
      },
      {
        "slug": "predominantly-lower-limb-lymphedema",
        "name": "Predominantly lower limb lymphedema",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/predominantly-lower-limb-lymphedema"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "prominent-superficial-veins",
        "name": "Prominent veins",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prominent-superficial-veins"
      },
      {
        "slug": "pulmonary-artery-atresia",
        "name": "Pulmonary artery atresia",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/pulmonary-artery-atresia"
      },
      {
        "slug": "right-aortic-arch",
        "name": "Right aortic arch",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/right-aortic-arch"
      },
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/brachydactyly"
      },
      {
        "slug": "neoplasm-of-the-skin",
        "name": "Skin cancer",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-skin"
      },
      {
        "slug": "specific-learning-disability",
        "name": "Specific learning disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/specific-learning-disability"
      },
      {
        "slug": "capillary-hemangioma",
        "name": "Strawberry birthmark",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/capillary-hemangioma"
      },
      {
        "slug": "hemangioma",
        "name": "Strawberry mark",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/hemangioma"
      },
      {
        "slug": "lymphedema",
        "name": "Swelling caused by excess lymph fluid under skin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/lymphedema"
      },
      {
        "slug": "tetralogy-of-fallot",
        "name": "Tetralogy of Fallot",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/tetralogy-of-fallot"
      },
      {
        "slug": "hypoplasia-of-lymphatic-vessels",
        "name": "Underdeveloped lymphatic vessels",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypoplasia-of-lymphatic-vessels"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "upslanting-toenail",
        "name": "Upslanting toenail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/upslanting-toenail"
      },
      {
        "slug": "urethral-stricture",
        "name": "Urethral stricture",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/urethral-stricture"
      },
      {
        "slug": "varicose-veins",
        "name": "Varicose veins",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/varicose-veins"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}