{
  "url": "https://dantelabs.com/no/genes/apoa5",
  "gene": {
    "slug": "apoa5",
    "symbol": "APOA5",
    "name": "apolipoprotein A5",
    "hgnc": "HGNC:17288",
    "summary": null,
    "location": "11q23.3",
    "locusType": "gene with protein product",
    "aliases": [
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      "APOA-V"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000110243",
    "entrezId": 116519,
    "omim": [
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    "uniprot": [
      "Q6Q788"
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 116789367,
      "end": 116791879,
      "strand": "-",
      "ensemblTranscript": "ENST00000227665.9",
      "refseqTranscript": "NM_001371904.1",
      "ensemblProtein": "ENSP00000227665.4",
      "refseqProtein": "NP_001358833.1",
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        {
          "start": 116789367,
          "end": 116791067
        },
        {
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        {
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          "end": 116791879
        }
      ],
      "cds": {
        "start": 116790128,
        "end": 116791860
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 116660083,
      "end": 116663136,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 116290623,
      "end": 117290622,
      "genes": [
        {
          "symbol": "BUD13",
          "ensemblId": "ENSG00000137656",
          "biotype": "protein_coding",
          "start": 116748170,
          "end": 116773039,
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        },
        {
          "symbol": "ZPR1",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "APOA4",
          "ensemblId": "ENSG00000110244",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "apoa4"
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        {
          "symbol": "APOC3",
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          "biotype": "protein_coding",
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          "end": 116835254,
          "strand": "+",
          "slug": "apoc3"
        },
        {
          "symbol": "APOA1",
          "ensemblId": "ENSG00000118137",
          "biotype": "protein_coding",
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          "end": 116842065,
          "strand": "-",
          "slug": "apoa1"
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        {
          "symbol": "SIK3",
          "ensemblId": "ENSG00000160584",
          "biotype": "protein_coding",
          "start": 116843402,
          "end": 117098463,
          "strand": "-",
          "slug": "sik3"
        },
        {
          "symbol": "PAFAH1B2",
          "ensemblId": "ENSG00000168092",
          "biotype": "protein_coding",
          "start": 117144278,
          "end": 117176894,
          "strand": "+",
          "slug": "pafah1b2"
        },
        {
          "symbol": "SIDT2",
          "ensemblId": "ENSG00000149577",
          "biotype": "protein_coding",
          "start": 117178730,
          "end": 117197452,
          "strand": "+",
          "slug": "sidt2"
        },
        {
          "symbol": "TAGLN",
          "ensemblId": "ENSG00000149591",
          "biotype": "protein_coding",
          "start": 117197509,
          "end": 117207464,
          "strand": "+",
          "slug": "tagln"
        },
        {
          "symbol": "PCSK7",
          "ensemblId": "ENSG00000160613",
          "biotype": "protein_coding",
          "start": 117202588,
          "end": 117232628,
          "strand": "-",
          "slug": "pcsk7"
        },
        {
          "symbol": "RNF214",
          "ensemblId": "ENSG00000167257",
          "biotype": "protein_coding",
          "start": 117232154,
          "end": 117287429,
          "strand": "+",
          "slug": "rnf214"
        },
        {
          "symbol": "BACE1",
          "ensemblId": "ENSG00000186318",
          "biotype": "protein_coding",
          "start": 117285232,
          "end": 117316291,
          "strand": "-",
          "slug": "bace1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hyperlipidemia",
        "name": "Hyperlipidemi",
        "diseases": [
          {
            "mondoId": "MONDO:0021187",
            "name": "Hyperlipidemi",
            "genes": 11,
            "inheritance": null,
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/hyperlipidemia"
      },
      {
        "slug": "hypertriglyceridemia",
        "name": "Hypertriglyseridemi",
        "diseases": [
          {
            "mondoId": "MONDO:0005347",
            "name": "Hypertriglyseridemi",
            "genes": 2,
            "inheritance": null,
            "description": "Et laboratorieresultat som viser forhøyet konsentrasjon av triglyserider i blodet.",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/hypertriglyceridemia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "atheroeruptive-xanthoma",
        "name": "Atheroeruptive xanthoma",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/atheroeruptive-xanthoma"
      },
      {
        "slug": "decreased-circulating-hdl-c-concentration",
        "name": "Decreased circulating high-density lipoprotein cholesterol",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/decreased-circulating-hdl-c-concentration"
      },
      {
        "slug": "decreased-circulating-ldl-c-concentration",
        "name": "Decreased circulating LDL-C concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/decreased-circulating-ldl-c-concentration"
      },
      {
        "slug": "diabetes-mellitus",
        "name": "Diabetes mellitus",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/diabetes-mellitus"
      },
      {
        "slug": "elevated-circulating-vldl-c-concentration",
        "name": "Elevated circulating VLDL-C concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/elevated-circulating-vldl-c-concentration"
      },
      {
        "slug": "glucose-intolerance",
        "name": "Glucose intolerance",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/glucose-intolerance"
      },
      {
        "slug": "hypopituitarism",
        "name": "Hypopituitarism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/hypopituitarism"
      },
      {
        "slug": "increased-circulating-chylomicron-concentration",
        "name": "Increased circulating chylomicron concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/increased-circulating-chylomicron-concentration"
      },
      {
        "slug": "hypertriglyceridemia",
        "name": "Increased plasma triglycerides",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hypertriglyceridemia"
      },
      {
        "slug": "precocious-atherosclerosis",
        "name": "Premature plaque build-up in arteries",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/precocious-atherosclerosis"
      }
    ],
    "related": [
      {
        "slug": "apob",
        "symbol": "APOB",
        "name": "apolipoprotein B",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/apob"
      },
      {
        "slug": "apoc2",
        "symbol": "APOC2",
        "name": "apolipoprotein C2",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/apoc2"
      },
      {
        "slug": "apoe",
        "symbol": "APOE",
        "name": "apolipoprotein E",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/apoe"
      },
      {
        "slug": "cetp",
        "symbol": "CETP",
        "name": "cholesteryl ester transfer protein",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/cetp"
      },
      {
        "slug": "creb3l3",
        "symbol": "CREB3L3",
        "name": "cAMP responsive element binding protein 3 like 3",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/creb3l3"
      },
      {
        "slug": "gpihbp1",
        "symbol": "GPIHBP1",
        "name": "glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/gpihbp1"
      },
      {
        "slug": "ldlr",
        "symbol": "LDLR",
        "name": "low density lipoprotein receptor",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/ldlr"
      },
      {
        "slug": "ldlrap1",
        "symbol": "LDLRAP1",
        "name": "low density lipoprotein receptor adaptor protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/ldlrap1"
      },
      {
        "slug": "lipc",
        "symbol": "LIPC",
        "name": "lipase C, hepatic type",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/lipc"
      },
      {
        "slug": "lpl",
        "symbol": "LPL",
        "name": "lipoprotein lipase",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/lpl"
      },
      {
        "slug": "pcsk9",
        "symbol": "PCSK9",
        "name": "proprotein convertase subtilisin/kexin type 9",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/pcsk9"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}