{
  "url": "https://dantelabs.com/no/genes/apcdd1",
  "gene": {
    "slug": "apcdd1",
    "symbol": "APCDD1",
    "name": "APC down-regulated 1",
    "hgnc": "HGNC:15718",
    "summary": null,
    "location": "18p11.22",
    "locusType": "gene with protein product",
    "aliases": [
      "B7323"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000154856",
    "entrezId": 147495,
    "omim": [
      "607479"
    ],
    "uniprot": [
      "Q8J025"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "18",
      "start": 10454635,
      "end": 10489949,
      "strand": "+",
      "ensemblTranscript": "ENST00000355285.10",
      "refseqTranscript": "NM_153000.5",
      "ensemblProtein": "ENSP00000347433.4",
      "refseqProtein": "NP_694545.1",
      "exons": [
        {
          "start": 10454635,
          "end": 10455039
        },
        {
          "start": 10468469,
          "end": 10468652
        },
        {
          "start": 10471530,
          "end": 10472061
        },
        {
          "start": 10485462,
          "end": 10485783
        },
        {
          "start": 10487590,
          "end": 10489949
        }
      ],
      "cds": {
        "start": 10454982,
        "end": 10488038
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "18",
      "start": 10454625,
      "end": 10489945,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 9972292,
      "end": 10972291,
      "genes": [
        {
          "symbol": "NAPG",
          "ensemblId": "ENSG00000134265",
          "biotype": "protein_coding",
          "start": 10525905,
          "end": 10553249,
          "strand": "+",
          "slug": "napg"
        },
        {
          "symbol": "PIEZO2",
          "ensemblId": "ENSG00000154864",
          "biotype": "protein_coding",
          "start": 10666483,
          "end": 11149591,
          "strand": "-",
          "slug": "piezo2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-hypotrichosis-and-hair-shaft-disorders",
        "name": "Arvelig hypotrichose, ullhår og monilethrix",
        "diseases": [
          {
            "mondoId": "MONDO:0003037",
            "name": "Arvelig hypotrichose",
            "genes": 11,
            "inheritance": null,
            "description": "Tynt eller fraværende hår i hodebunnen og på kroppen fra barndommen, inkludert de LIPH- og LPAR6-relaterte formene.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/no/conditions/hereditary-hypotrichosis-and-hair-shaft-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/alopecia"
      },
      {
        "slug": "sparse-axillary-hair",
        "name": "Limited armpit hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/sparse-axillary-hair"
      },
      {
        "slug": "sparse-body-hair",
        "name": "Sparse body hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-body-hair"
      },
      {
        "slug": "sparse-eyebrow",
        "name": "Sparse eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-eyebrow"
      },
      {
        "slug": "sparse-eyelashes",
        "name": "Sparse eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-eyelashes"
      },
      {
        "slug": "sparse-hair",
        "name": "Sparse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-hair"
      },
      {
        "slug": "sparse-pubic-hair",
        "name": "Sparse pubic hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/sparse-pubic-hair"
      },
      {
        "slug": "sparse-scalp-hair",
        "name": "Sparse scalp hair",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-scalp-hair"
      }
    ],
    "related": [
      {
        "slug": "c3orf52",
        "symbol": "C3orf52",
        "name": "chromosome 3 open reading frame 52",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/c3orf52"
      },
      {
        "slug": "cdh3",
        "symbol": "CDH3",
        "name": "cadherin 3",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/cdh3"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "name": "corneodesmosin",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/cdsn"
      },
      {
        "slug": "dsg4",
        "symbol": "DSG4",
        "name": "desmoglein 4",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/dsg4"
      },
      {
        "slug": "hr",
        "symbol": "HR",
        "name": "HR lysine demethylase and nuclear receptor corepressor",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/hr"
      },
      {
        "slug": "liph",
        "symbol": "LIPH",
        "name": "lipase H",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/liph"
      },
      {
        "slug": "lpar6",
        "symbol": "LPAR6",
        "name": "lysophosphatidic acid receptor 6",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/lpar6"
      },
      {
        "slug": "lss",
        "symbol": "LSS",
        "name": "lanosterol synthase",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/lss"
      },
      {
        "slug": "rpl21",
        "symbol": "RPL21",
        "name": "ribosomal protein L21",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/rpl21"
      },
      {
        "slug": "snrpe",
        "symbol": "SNRPE",
        "name": "small nuclear ribonucleoprotein polypeptide E",
        "shared": 1,
        "url": "https://dantelabs.com/no/genes/snrpe"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}