{
  "url": "https://dantelabs.com/traits/wrist-drop",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "wrist-drop",
    "id": "HP:0031189",
    "name": "Wrist drop",
    "definition": "A condition in which the affected individual cannot extend the wrist, which hangs flaccidly.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "upper-limb-muscle-weakness",
        "name": "Decreased arm strength",
        "url": "https://dantelabs.com/traits/upper-limb-muscle-weakness"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dst",
        "symbol": "DST",
        "hgnc": "HGNC:1090",
        "name": "dystonin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dst"
      },
      {
        "slug": "reep1",
        "symbol": "REEP1",
        "hgnc": "HGNC:25786",
        "name": "receptor accessory protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reep1"
      },
      {
        "slug": "acta1",
        "symbol": "ACTA1",
        "hgnc": "HGNC:129",
        "name": "actin alpha 1, skeletal muscle",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acta1"
      },
      {
        "slug": "cadm3",
        "symbol": "CADM3",
        "hgnc": "HGNC:17601",
        "name": "cell adhesion molecule 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cadm3"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      },
      {
        "slug": "morc2",
        "symbol": "MORC2",
        "hgnc": "HGNC:23573",
        "name": "MORC family CW-type zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/morc2"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "plod1",
        "symbol": "PLOD1",
        "hgnc": "HGNC:9081",
        "name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plod1"
      }
    ]
  }
}