{
  "url": "https://dantelabs.com/traits/vertebral-clefting",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "vertebral-clefting",
    "id": "HP:0008428",
    "name": "Vertebral clefting",
    "definition": "Schisis (cleft or cleavage) of vertebral bodies.",
    "synonyms": [
      "Vertebral clefts"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-vertebral-body-morphology",
        "name": "Abnormal vertebral body morphology",
        "url": "https://dantelabs.com/traits/abnormal-vertebral-body-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "butterfly-vertebrae",
        "name": "Butterfly vertebrae",
        "genes": 22,
        "url": "https://dantelabs.com/traits/butterfly-vertebrae"
      },
      {
        "slug": "coronal-cleft-vertebrae",
        "name": "Coronal cleft vertebrae",
        "genes": 18,
        "url": "https://dantelabs.com/traits/coronal-cleft-vertebrae"
      },
      {
        "slug": "anterior-clefting-of-vertebral-bodies",
        "name": "Anterior clefting of vertebral bodies",
        "genes": 1,
        "url": "https://dantelabs.com/traits/anterior-clefting-of-vertebral-bodies"
      }
    ],
    "genes": [
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "rad21",
        "symbol": "RAD21",
        "hgnc": "HGNC:9811",
        "name": "RAD21 cohesin complex component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad21"
      },
      {
        "slug": "tbxt",
        "symbol": "TBXT",
        "hgnc": "HGNC:11515",
        "name": "T-box transcription factor T",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbxt"
      },
      {
        "slug": "sox5",
        "symbol": "SOX5",
        "hgnc": "HGNC:11201",
        "name": "SRY-box transcription factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox5"
      },
      {
        "slug": "stag2",
        "symbol": "STAG2",
        "hgnc": "HGNC:11355",
        "name": "STAG2 cohesin complex component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stag2"
      },
      {
        "slug": "alpl",
        "symbol": "ALPL",
        "hgnc": "HGNC:438",
        "name": "alkaline phosphatase, biomineralization associated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpl"
      },
      {
        "slug": "hspa9",
        "symbol": "HSPA9",
        "hgnc": "HGNC:5244",
        "name": "heat shock protein family A (Hsp70) member 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspa9"
      },
      {
        "slug": "mesp2",
        "symbol": "MESP2",
        "hgnc": "HGNC:29659",
        "name": "mesoderm posterior bHLH transcription factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mesp2"
      }
    ]
  }
}