{
  "url": "https://dantelabs.com/traits/thyroid-hypoplasia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "thyroid-hypoplasia",
    "id": "HP:0005990",
    "name": "Small thyroid gland",
    "label": "Thyroid hypoplasia",
    "definition": "Developmental hypoplasia of the thyroid gland.",
    "synonyms": [
      "Hypoplastic thyroid"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-thyroid-gland",
        "name": "Aplasia/Hypoplasia of the thyroid gland",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-thyroid-gland"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "hgnc": "HGNC:8622",
        "name": "paired box 8",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pax8"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "tshb",
        "symbol": "TSHB",
        "hgnc": "HGNC:12372",
        "name": "thyroid stimulating hormone subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshb"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tshr"
      },
      {
        "slug": "adamtsl1",
        "symbol": "ADAMTSL1",
        "hgnc": "HGNC:14632",
        "name": "ADAMTS like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamtsl1"
      },
      {
        "slug": "hesx1",
        "symbol": "HESX1",
        "hgnc": "HGNC:4877",
        "name": "HESX homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hesx1"
      },
      {
        "slug": "irs4",
        "symbol": "IRS4",
        "hgnc": "HGNC:6128",
        "name": "insulin receptor substrate 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irs4"
      },
      {
        "slug": "kat6b",
        "symbol": "KAT6B",
        "hgnc": "HGNC:17582",
        "name": "lysine acetyltransferase 6B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kat6b"
      },
      {
        "slug": "lhx3",
        "symbol": "LHX3",
        "hgnc": "HGNC:6595",
        "name": "LIM homeobox 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx3"
      },
      {
        "slug": "lhx4",
        "symbol": "LHX4",
        "hgnc": "HGNC:21734",
        "name": "LIM homeobox 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx4"
      },
      {
        "slug": "pou1f1",
        "symbol": "POU1F1",
        "hgnc": "HGNC:9210",
        "name": "POU class 1 homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou1f1"
      },
      {
        "slug": "prop1",
        "symbol": "PROP1",
        "hgnc": "HGNC:9455",
        "name": "PROP paired-like homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prop1"
      },
      {
        "slug": "trhr",
        "symbol": "TRHR",
        "hgnc": "HGNC:12299",
        "name": "thyrotropin releasing hormone receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trhr"
      },
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "gnb2",
        "symbol": "GNB2",
        "hgnc": "HGNC:4398",
        "name": "G protein subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb2"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "polr1b",
        "symbol": "POLR1B",
        "hgnc": "HGNC:20454",
        "name": "RNA polymerase I subunit B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1b"
      },
      {
        "slug": "polr1c",
        "symbol": "POLR1C",
        "hgnc": "HGNC:20194",
        "name": "RNA polymerase I and III subunit C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1c"
      },
      {
        "slug": "polr1d",
        "symbol": "POLR1D",
        "hgnc": "HGNC:20422",
        "name": "RNA polymerase I and III subunit D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1d"
      },
      {
        "slug": "tcof1",
        "symbol": "TCOF1",
        "hgnc": "HGNC:11654",
        "name": "treacle ribosome biogenesis factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcof1"
      },
      {
        "slug": "duox2",
        "symbol": "DUOX2",
        "hgnc": "HGNC:13273",
        "name": "dual oxidase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/duox2"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      }
    ]
  }
}