{
  "url": "https://dantelabs.com/traits/thumb-contracture",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "thumb-contracture",
    "id": "HP:0009600",
    "name": "Thumb contracture",
    "definition": "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the thumb joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin. The term camptodactyly is used if the distal and/or proximal interphalangeal joints are affected.",
    "synonyms": [
      "Contracture of thumb",
      "Flexion deformities of thumbs",
      "Joint contractures of the thumb",
      "Thumb joint contracture"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-thumb-morphology",
        "name": "Abnormality of the thumb",
        "url": "https://dantelabs.com/traits/abnormal-thumb-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "interphalangeal-thumb-joint-contracture",
        "name": "Interphalangeal thumb joint contracture",
        "genes": 2,
        "url": "https://dantelabs.com/traits/interphalangeal-thumb-joint-contracture"
      },
      {
        "slug": "metacarpophalangeal-thumb-joint-contracture",
        "name": "Metacarpophalangeal thumb joint contracture",
        "genes": 1,
        "url": "https://dantelabs.com/traits/metacarpophalangeal-thumb-joint-contracture"
      }
    ],
    "genes": [
      {
        "slug": "l1cam",
        "symbol": "L1CAM",
        "hgnc": "HGNC:6470",
        "name": "L1 cell adhesion molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/l1cam"
      },
      {
        "slug": "dlk1",
        "symbol": "DLK1",
        "hgnc": "HGNC:2907",
        "name": "delta like non-canonical Notch ligand 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlk1"
      },
      {
        "slug": "meg3",
        "symbol": "MEG3",
        "hgnc": "HGNC:14575",
        "name": "maternally expressed 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meg3"
      },
      {
        "slug": "rtl1",
        "symbol": "RTL1",
        "hgnc": "HGNC:14665",
        "name": "retrotransposon Gag like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtl1"
      },
      {
        "slug": "bmp4",
        "symbol": "BMP4",
        "hgnc": "HGNC:1071",
        "name": "bone morphogenetic protein 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp4"
      }
    ]
  }
}