{
  "url": "https://dantelabs.com/traits/subcapsular-cataract",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "subcapsular-cataract",
    "id": "HP:0000523",
    "name": "Subcapsular cataract",
    "definition": "A cataract that affects the region of the lens directly beneath the capsule of the lens.",
    "synonyms": [
      "Subcapsular cataracts",
      "Subcapsular lenticular cataracts",
      "Subcapsular opacities"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "cataract",
        "name": "Clouding of the lens of the eye",
        "url": "https://dantelabs.com/traits/cataract"
      }
    ],
    "narrower": [
      {
        "slug": "posterior-subcapsular-cataract",
        "name": "Posterior subcapsular cataract",
        "genes": 126,
        "url": "https://dantelabs.com/traits/posterior-subcapsular-cataract"
      },
      {
        "slug": "anterior-subcapsular-cataract",
        "name": "Anterior subcapsular cataract",
        "genes": 5,
        "url": "https://dantelabs.com/traits/anterior-subcapsular-cataract"
      }
    ],
    "genes": [
      {
        "slug": "nr6a1",
        "symbol": "NR6A1",
        "hgnc": "HGNC:7985",
        "name": "nuclear receptor subfamily 6 group A member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr6a1"
      },
      {
        "slug": "tmem216",
        "symbol": "TMEM216",
        "hgnc": "HGNC:25018",
        "name": "transmembrane protein 216",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem216"
      },
      {
        "slug": "cyp1b1",
        "symbol": "CYP1B1",
        "hgnc": "HGNC:2597",
        "name": "cytochrome P450 family 1 subfamily B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp1b1"
      },
      {
        "slug": "foxc1",
        "symbol": "FOXC1",
        "hgnc": "HGNC:3800",
        "name": "forkhead box C1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxc1"
      },
      {
        "slug": "foxe3",
        "symbol": "FOXE3",
        "hgnc": "HGNC:3808",
        "name": "forkhead box E3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxe3"
      },
      {
        "slug": "pax6",
        "symbol": "PAX6",
        "hgnc": "HGNC:8620",
        "name": "paired box 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax6"
      },
      {
        "slug": "pitx2",
        "symbol": "PITX2",
        "hgnc": "HGNC:9005",
        "name": "paired like homeodomain 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pitx2"
      },
      {
        "slug": "abhd5",
        "symbol": "ABHD5",
        "hgnc": "HGNC:21396",
        "name": "abhydrolase domain containing 5, lysophosphatidic acid acyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abhd5"
      },
      {
        "slug": "oat",
        "symbol": "OAT",
        "hgnc": "HGNC:8091",
        "name": "ornithine aminotransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oat"
      },
      {
        "slug": "prpf8",
        "symbol": "PRPF8",
        "hgnc": "HGNC:17340",
        "name": "pre-mRNA processing factor 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prpf8"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "col4a4",
        "symbol": "COL4A4",
        "hgnc": "HGNC:2206",
        "name": "collagen type IV alpha 4 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a4"
      },
      {
        "slug": "abhd12",
        "symbol": "ABHD12",
        "hgnc": "HGNC:15868",
        "name": "abhydrolase domain containing 12, lysophospholipase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abhd12"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "fzd4",
        "symbol": "FZD4",
        "hgnc": "HGNC:4042",
        "name": "frizzled class receptor 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzd4"
      },
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrp5"
      }
    ]
  }
}