{
  "url": "https://dantelabs.com/traits/right-aortic-arch",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "right-aortic-arch",
    "id": "HP:0012020",
    "name": "Right aortic arch",
    "definition": "Aorta descends on right instead of on the left.",
    "synonyms": [
      "Right-sided aortic arch"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-branching-pattern-of-the-aortic-arch",
        "name": "Abnormal branching pattern of the aortic arch",
        "url": "https://dantelabs.com/traits/abnormal-branching-pattern-of-the-aortic-arch"
      }
    ],
    "narrower": [
      {
        "slug": "right-aortic-arch-with-mirror-image-branching",
        "name": "Right aortic arch with mirror image branching",
        "genes": 7,
        "url": "https://dantelabs.com/traits/right-aortic-arch-with-mirror-image-branching"
      }
    ],
    "genes": [
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "hgnc": "HGNC:2940",
        "name": "dynein axonemal heavy chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah1"
      },
      {
        "slug": "srsf1",
        "symbol": "SRSF1",
        "hgnc": "HGNC:10780",
        "name": "serine and arginine rich splicing factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srsf1"
      },
      {
        "slug": "acvr2b",
        "symbol": "ACVR2B",
        "hgnc": "HGNC:174",
        "name": "activin A receptor type 2B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvr2b"
      },
      {
        "slug": "cfap53",
        "symbol": "CFAP53",
        "hgnc": "HGNC:26530",
        "name": "cilia and flagella associated protein 53",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap53"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "clxn",
        "symbol": "CLXN",
        "hgnc": "HGNC:25678",
        "name": "calaxin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clxn"
      },
      {
        "slug": "pkd1l1",
        "symbol": "PKD1L1",
        "hgnc": "HGNC:18053",
        "name": "polycystin 1 like 1, transient receptor potential channel interacting",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd1l1"
      },
      {
        "slug": "plxnd1",
        "symbol": "PLXND1",
        "hgnc": "HGNC:9107",
        "name": "plexin D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plxnd1"
      },
      {
        "slug": "zmym3",
        "symbol": "ZMYM3",
        "hgnc": "HGNC:13054",
        "name": "zinc finger MYM-type containing 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmym3"
      },
      {
        "slug": "dnah9",
        "symbol": "DNAH9",
        "hgnc": "HGNC:2953",
        "name": "dynein axonemal heavy chain 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah9"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "mmp21",
        "symbol": "MMP21",
        "hgnc": "HGNC:14357",
        "name": "matrix metallopeptidase 21",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp21"
      },
      {
        "slug": "sf3b2",
        "symbol": "SF3B2",
        "hgnc": "HGNC:10769",
        "name": "splicing factor 3b subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b2"
      },
      {
        "slug": "tbck",
        "symbol": "TBCK",
        "hgnc": "HGNC:28261",
        "name": "TBC1 domain containing kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbck"
      },
      {
        "slug": "tmem260",
        "symbol": "TMEM260",
        "hgnc": "HGNC:20185",
        "name": "transmembrane protein 260",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem260"
      },
      {
        "slug": "wdr26",
        "symbol": "WDR26",
        "hgnc": "HGNC:21208",
        "name": "WD repeat domain 26",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wdr26"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "cirop",
        "symbol": "CIROP",
        "hgnc": "HGNC:53647",
        "name": "ciliated left-right organizer metallopeptidase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cirop"
      },
      {
        "slug": "flt4",
        "symbol": "FLT4",
        "hgnc": "HGNC:3767",
        "name": "fms related receptor tyrosine kinase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt4"
      },
      {
        "slug": "gdf1",
        "symbol": "GDF1",
        "hgnc": "HGNC:4214",
        "name": "growth differentiation factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf1"
      }
    ]
  }
}