{
  "url": "https://dantelabs.com/traits/reduced-factor-ix-activity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "reduced-factor-ix-activity",
    "id": "HP:0011858",
    "name": "Reduced factor IX activity",
    "definition": "Decreased activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.",
    "synonyms": [
      "Low factor IX activity"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-factor-ix-activity",
        "name": "Abnormal factor IX activity",
        "url": "https://dantelabs.com/traits/abnormal-factor-ix-activity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "f9",
        "symbol": "F9",
        "hgnc": "HGNC:3551",
        "name": "coagulation factor IX",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f9"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "hgnc": "HGNC:23663",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vkorc1"
      },
      {
        "slug": "pmm2",
        "symbol": "PMM2",
        "hgnc": "HGNC:9115",
        "name": "phosphomannomutase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmm2"
      },
      {
        "slug": "mgat2",
        "symbol": "MGAT2",
        "hgnc": "HGNC:7045",
        "name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mgat2"
      }
    ]
  }
}