{
  "url": "https://dantelabs.com/traits/polycythemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "polycythemia",
    "id": "HP:0001901",
    "name": "Increased red blood cells",
    "label": "Polycythemia",
    "definition": "Polycythemia is diagnosed if the red blood cell count, the hemoglobin level, and the red blood cell volume all exceed the upper limits of normal.",
    "synonyms": [
      "Abnormally shaped erythrocytes",
      "Erythrocytosis",
      "Polyglobulia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-erythrocyte-morphology",
        "name": "Abnormal erythrocyte morphology",
        "url": "https://dantelabs.com/traits/abnormal-erythrocyte-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "increased-circulating-hemoglobin-concentration",
        "name": "Increased circulating hemoglobin concentration",
        "genes": 14,
        "url": "https://dantelabs.com/traits/increased-circulating-hemoglobin-concentration"
      },
      {
        "slug": "increased-red-blood-cell-mass",
        "name": "Increased red blood cell mass",
        "genes": 5,
        "url": "https://dantelabs.com/traits/increased-red-blood-cell-mass"
      }
    ],
    "genes": [
      {
        "slug": "bpgm",
        "symbol": "BPGM",
        "hgnc": "HGNC:1093",
        "name": "bisphosphoglycerate mutase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bpgm"
      },
      {
        "slug": "ednrb",
        "symbol": "EDNRB",
        "hgnc": "HGNC:3180",
        "name": "endothelin receptor type B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ednrb"
      },
      {
        "slug": "epas1",
        "symbol": "EPAS1",
        "hgnc": "HGNC:3374",
        "name": "endothelial PAS domain protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epas1"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "epor",
        "symbol": "EPOR",
        "hgnc": "HGNC:3416",
        "name": "erythropoietin receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epor"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "slc30a10",
        "symbol": "SLC30A10",
        "hgnc": "HGNC:25355",
        "name": "solute carrier family 30 member 10",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc30a10"
      },
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "hgnc": "HGNC:1101",
        "name": "BRCA2 DNA repair associated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca2"
      },
      {
        "slug": "ctr9",
        "symbol": "CTR9",
        "hgnc": "HGNC:16850",
        "name": "CTR9 component of Paf1/RNA polymerase II complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctr9"
      },
      {
        "slug": "dis3l2",
        "symbol": "DIS3L2",
        "hgnc": "HGNC:28648",
        "name": "DIS3 like 3'-5' exoribonuclease 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dis3l2"
      },
      {
        "slug": "fh",
        "symbol": "FH",
        "hgnc": "HGNC:3700",
        "name": "fumarate hydratase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fh"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "h19",
        "symbol": "H19",
        "hgnc": "HGNC:4713",
        "name": "H19 imprinted maternally expressed transcript",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h19"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "pou6f2",
        "symbol": "POU6F2",
        "hgnc": "HGNC:21694",
        "name": "POU class 6 homeobox 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou6f2"
      },
      {
        "slug": "rest",
        "symbol": "REST",
        "hgnc": "HGNC:9966",
        "name": "RE1 silencing transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rest"
      },
      {
        "slug": "trim28",
        "symbol": "TRIM28",
        "hgnc": "HGNC:16384",
        "name": "tripartite motif containing 28",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim28"
      },
      {
        "slug": "trip13",
        "symbol": "TRIP13",
        "hgnc": "HGNC:12307",
        "name": "thyroid hormone receptor interactor 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip13"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "kcnn4",
        "symbol": "KCNN4",
        "hgnc": "HGNC:6293",
        "name": "potassium calcium-activated channel subfamily N member 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn4"
      },
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "hgnc": "HGNC:28993",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo1"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "vhl",
        "symbol": "VHL",
        "hgnc": "HGNC:12687",
        "name": "von Hippel-Lindau tumor suppressor",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vhl"
      },
      {
        "slug": "acvrl1",
        "symbol": "ACVRL1",
        "hgnc": "HGNC:175",
        "name": "activin A receptor like type 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvrl1"
      },
      {
        "slug": "cyb5r3",
        "symbol": "CYB5R3",
        "hgnc": "HGNC:2873",
        "name": "cytochrome b5 reductase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyb5r3"
      },
      {
        "slug": "eng",
        "symbol": "ENG",
        "hgnc": "HGNC:3349",
        "name": "endoglin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eng"
      },
      {
        "slug": "epo",
        "symbol": "EPO",
        "hgnc": "HGNC:3415",
        "name": "erythropoietin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epo"
      },
      {
        "slug": "hba1",
        "symbol": "HBA1",
        "hgnc": "HGNC:4823",
        "name": "hemoglobin subunit alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hba1"
      },
      {
        "slug": "hba2",
        "symbol": "HBA2",
        "hgnc": "HGNC:4824",
        "name": "hemoglobin subunit alpha 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hba2"
      },
      {
        "slug": "pklr",
        "symbol": "PKLR",
        "hgnc": "HGNC:9020",
        "name": "pyruvate kinase L/R",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pklr"
      }
    ]
  }
}