{
  "url": "https://dantelabs.com/traits/nail-dystrophy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "nail-dystrophy",
    "id": "HP:0008404",
    "name": "Poor nail formation",
    "label": "Nail dystrophy",
    "definition": "Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate.",
    "synonyms": [
      "Dystrophic nails",
      "Onychodystrophy"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nail-morphology",
        "name": "Abnormality of the nail",
        "url": "https://dantelabs.com/traits/abnormal-nail-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "dystrophic-fingernails",
        "name": "Poor fingernail formation",
        "genes": 33,
        "url": "https://dantelabs.com/traits/dystrophic-fingernails"
      },
      {
        "slug": "dystrophic-toenail",
        "name": "Poor toenail formation",
        "genes": 21,
        "url": "https://dantelabs.com/traits/dystrophic-toenail"
      }
    ],
    "genes": [
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "obligate",
        "diseases": 13,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "dkc1",
        "symbol": "DKC1",
        "hgnc": "HGNC:2890",
        "name": "dyskerin pseudouridine synthase 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/dkc1"
      },
      {
        "slug": "dsg1",
        "symbol": "DSG1",
        "hgnc": "HGNC:3048",
        "name": "desmoglein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg1"
      },
      {
        "slug": "grhl2",
        "symbol": "GRHL2",
        "hgnc": "HGNC:2799",
        "name": "grainyhead like transcription factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grhl2"
      },
      {
        "slug": "hoxc13",
        "symbol": "HOXC13",
        "hgnc": "HGNC:5125",
        "name": "homeobox C13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxc13"
      },
      {
        "slug": "itga3",
        "symbol": "ITGA3",
        "hgnc": "HGNC:6139",
        "name": "integrin subunit alpha 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga3"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "obligate",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "obligate",
        "diseases": 7,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt16",
        "symbol": "KRT16",
        "hgnc": "HGNC:6423",
        "name": "keratin 16",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt16"
      },
      {
        "slug": "krt17",
        "symbol": "KRT17",
        "hgnc": "HGNC:6427",
        "name": "keratin 17",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt17"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "obligate",
        "diseases": 7,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "krt6a",
        "symbol": "KRT6A",
        "hgnc": "HGNC:6443",
        "name": "keratin 6A",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/krt6a"
      },
      {
        "slug": "krt6b",
        "symbol": "KRT6B",
        "hgnc": "HGNC:6444",
        "name": "keratin 6B",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/krt6b"
      },
      {
        "slug": "krt85",
        "symbol": "KRT85",
        "hgnc": "HGNC:6462",
        "name": "keratin 85",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt85"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "mars1",
        "symbol": "MARS1",
        "hgnc": "HGNC:6898",
        "name": "methionyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mars1"
      },
      {
        "slug": "mplkip",
        "symbol": "MPLKIP",
        "hgnc": "HGNC:16002",
        "name": "M-phase specific PLK1 interacting protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mplkip"
      },
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "nhp2",
        "symbol": "NHP2",
        "hgnc": "HGNC:14377",
        "name": "NHP2 ribonucleoprotein",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nhp2"
      },
      {
        "slug": "nlrp1",
        "symbol": "NLRP1",
        "hgnc": "HGNC:14374",
        "name": "NLR family pyrin domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nlrp1"
      },
      {
        "slug": "nop10",
        "symbol": "NOP10",
        "hgnc": "HGNC:14378",
        "name": "NOP10 ribonucleoprotein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nop10"
      },
      {
        "slug": "pkp1",
        "symbol": "PKP1",
        "hgnc": "HGNC:9023",
        "name": "plakophilin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pkp1"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "rnu6atac",
        "symbol": "RNU6ATAC",
        "hgnc": "HGNC:34017",
        "name": "RNA, U6atac small nuclear",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu6atac"
      },
      {
        "slug": "sash1",
        "symbol": "SASH1",
        "hgnc": "HGNC:19182",
        "name": "SAM and SH3 domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sash1"
      },
      {
        "slug": "sting1",
        "symbol": "STING1",
        "hgnc": "HGNC:27962",
        "name": "stimulator of interferon response cGAMP interactor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sting1"
      },
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "obligate",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/tinf2"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "tyms",
        "symbol": "TYMS",
        "hgnc": "HGNC:12441",
        "name": "thymidylate synthetase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tyms"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10a"
      },
      {
        "slug": "wrap53",
        "symbol": "WRAP53",
        "hgnc": "HGNC:25522",
        "name": "WD repeat containing antisense to TP53",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wrap53"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "abca12",
        "symbol": "ABCA12",
        "hgnc": "HGNC:14637",
        "name": "ATP binding cassette subfamily A member 12",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca12"
      },
      {
        "slug": "acd",
        "symbol": "ACD",
        "hgnc": "HGNC:25070",
        "name": "ACD shelterin complex subunit and telomerase recruitment factor",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/acd"
      },
      {
        "slug": "alox12b",
        "symbol": "ALOX12B",
        "hgnc": "HGNC:430",
        "name": "arachidonate 12-lipoxygenase, 12R type",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alox12b"
      },
      {
        "slug": "aloxe3",
        "symbol": "ALOXE3",
        "hgnc": "HGNC:13743",
        "name": "arachidonate epidermal lipoxygenase 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aloxe3"
      },
      {
        "slug": "asprv1",
        "symbol": "ASPRV1",
        "hgnc": "HGNC:26321",
        "name": "aspartic peptidase retroviral like 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asprv1"
      },
      {
        "slug": "atp2a2",
        "symbol": "ATP2A2",
        "hgnc": "HGNC:812",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2a2"
      },
      {
        "slug": "ctc1",
        "symbol": "CTC1",
        "hgnc": "HGNC:26169",
        "name": "CST telomere replication complex component 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctc1"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "cyp4f22",
        "symbol": "CYP4F22",
        "hgnc": "HGNC:26820",
        "name": "cytochrome P450 family 4 subfamily F member 22",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp4f22"
      },
      {
        "slug": "dna2",
        "symbol": "DNA2",
        "hgnc": "HGNC:2939",
        "name": "DNA replication helicase/nuclease 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dna2"
      },
      {
        "slug": "evc",
        "symbol": "EVC",
        "hgnc": "HGNC:3497",
        "name": "EvC ciliary complex subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc"
      },
      {
        "slug": "evc2",
        "symbol": "EVC2",
        "hgnc": "HGNC:19747",
        "name": "EvC ciliary complex subunit 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc2"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "kdf1",
        "symbol": "KDF1",
        "hgnc": "HGNC:26624",
        "name": "keratinocyte differentiation factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdf1"
      },
      {
        "slug": "lipn",
        "symbol": "LIPN",
        "hgnc": "HGNC:23452",
        "name": "lipase family member N",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipn"
      },
      {
        "slug": "lss",
        "symbol": "LSS",
        "hgnc": "HGNC:6708",
        "name": "lanosterol synthase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lss"
      },
      {
        "slug": "nipal4",
        "symbol": "NIPAL4",
        "hgnc": "HGNC:28018",
        "name": "NIPA like domain containing 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nipal4"
      },
      {
        "slug": "npm1",
        "symbol": "NPM1",
        "hgnc": "HGNC:7910",
        "name": "nucleophosmin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npm1"
      },
      {
        "slug": "parn",
        "symbol": "PARN",
        "hgnc": "HGNC:8609",
        "name": "poly(A)-specific ribonuclease",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/parn"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/porcn"
      },
      {
        "slug": "rtel1",
        "symbol": "RTEL1",
        "hgnc": "HGNC:15888",
        "name": "regulator of telomere elongation helicase 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/rtel1"
      },
      {
        "slug": "sdr9c7",
        "symbol": "SDR9C7",
        "hgnc": "HGNC:29958",
        "name": "short chain dehydrogenase/reductase family 9C member 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdr9c7"
      },
      {
        "slug": "sult2b1",
        "symbol": "SULT2B1",
        "hgnc": "HGNC:11459",
        "name": "sulfotransferase family 2B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sult2b1"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tgm1",
        "symbol": "TGM1",
        "hgnc": "HGNC:11777",
        "name": "transglutaminase 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tgm1"
      },
      {
        "slug": "usb1",
        "symbol": "USB1",
        "hgnc": "HGNC:25792",
        "name": "U6 snRNA biogenesis phosphodiesterase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/usb1"
      },
      {
        "slug": "abca1",
        "symbol": "ABCA1",
        "hgnc": "HGNC:29",
        "name": "ATP binding cassette subfamily A member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abca1"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "hgnc": "HGNC:360",
        "name": "autoimmune regulator",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aire"
      },
      {
        "slug": "banf1",
        "symbol": "BANF1",
        "hgnc": "HGNC:17397",
        "name": "barrier to autointegration nuclear assembly factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/banf1"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "hgnc": "HGNC:2528",
        "name": "cathepsin C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsc"
      },
      {
        "slug": "dclre1b",
        "symbol": "DCLRE1B",
        "hgnc": "HGNC:17641",
        "name": "DNA cross-link repair 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1b"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "foxn1",
        "symbol": "FOXN1",
        "hgnc": "HGNC:12765",
        "name": "forkhead box N1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/foxn1"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "krt1",
        "symbol": "KRT1",
        "hgnc": "HGNC:6412",
        "name": "keratin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt1"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/lamc2"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      },
      {
        "slug": "nectin1",
        "symbol": "NECTIN1",
        "hgnc": "HGNC:9706",
        "name": "nectin cell adhesion molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin1"
      },
      {
        "slug": "nfkb2",
        "symbol": "NFKB2",
        "hgnc": "HGNC:7795",
        "name": "nuclear factor kappa B subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkb2"
      },
      {
        "slug": "pold3",
        "symbol": "POLD3",
        "hgnc": "HGNC:20932",
        "name": "DNA polymerase delta 3, accessory subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pold3"
      },
      {
        "slug": "pqbp1",
        "symbol": "PQBP1",
        "hgnc": "HGNC:9330",
        "name": "polyglutamine binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pqbp1"
      },
      {
        "slug": "rbck1",
        "symbol": "RBCK1",
        "hgnc": "HGNC:15864",
        "name": "RANBP2-type and C3HC4-type zinc finger containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbck1"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "ube2a",
        "symbol": "UBE2A",
        "hgnc": "HGNC:12472",
        "name": "ubiquitin conjugating enzyme E2 A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ube2a"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "anapc1",
        "symbol": "ANAPC1",
        "hgnc": "HGNC:19988",
        "name": "anaphase promoting complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anapc1"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "hgnc": "HGNC:1802",
        "name": "corneodesmosin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdsn"
      },
      {
        "slug": "cox7b",
        "symbol": "COX7B",
        "hgnc": "HGNC:2291",
        "name": "cytochrome c oxidase subunit 7B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox7b"
      },
      {
        "slug": "csta",
        "symbol": "CSTA",
        "hgnc": "HGNC:2481",
        "name": "cystatin A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csta"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "gabbr1",
        "symbol": "GABBR1",
        "hgnc": "HGNC:4070",
        "name": "gamma-aminobutyric acid type B receptor subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabbr1"
      },
      {
        "slug": "il36rn",
        "symbol": "IL36RN",
        "hgnc": "HGNC:15561",
        "name": "interleukin 36 receptor antagonist",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il36rn"
      },
      {
        "slug": "itga6",
        "symbol": "ITGA6",
        "hgnc": "HGNC:6142",
        "name": "integrin subunit alpha 6",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itga6"
      },
      {
        "slug": "kif15",
        "symbol": "KIF15",
        "hgnc": "HGNC:17273",
        "name": "kinesin family member 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif15"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "loricrin",
        "symbol": "LORICRIN",
        "hgnc": "HGNC:6663",
        "name": "loricrin cornified envelope precursor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/loricrin"
      },
      {
        "slug": "lrp1",
        "symbol": "LRP1",
        "hgnc": "HGNC:6692",
        "name": "LDL receptor related protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp1"
      },
      {
        "slug": "maf",
        "symbol": "MAF",
        "hgnc": "HGNC:6776",
        "name": "MAF bZIP transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/maf"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "mtx2",
        "symbol": "MTX2",
        "hgnc": "HGNC:7506",
        "name": "metaxin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtx2"
      },
      {
        "slug": "mvk",
        "symbol": "MVK",
        "hgnc": "HGNC:7530",
        "name": "mevalonate kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mvk"
      },
      {
        "slug": "naf1",
        "symbol": "NAF1",
        "hgnc": "HGNC:25126",
        "name": "nuclear assembly factor 1 ribonucleoprotein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naf1"
      },
      {
        "slug": "nfkbia",
        "symbol": "NFKBIA",
        "hgnc": "HGNC:7797",
        "name": "NFKB inhibitor alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkbia"
      },
      {
        "slug": "ppp1r13l",
        "symbol": "PPP1R13L",
        "hgnc": "HGNC:18838",
        "name": "protein phosphatase 1 regulatory subunit 13 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1r13l"
      },
      {
        "slug": "rpa1",
        "symbol": "RPA1",
        "hgnc": "HGNC:10289",
        "name": "replication protein A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpa1"
      },
      {
        "slug": "sat1",
        "symbol": "SAT1",
        "hgnc": "HGNC:10540",
        "name": "spermidine/spermine N1-acetyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sat1"
      },
      {
        "slug": "sel1l",
        "symbol": "SEL1L",
        "hgnc": "HGNC:10717",
        "name": "SEL1L adaptor subunit of SYVN1 ubiquitin ligase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sel1l"
      },
      {
        "slug": "smarcad1",
        "symbol": "SMARCAD1",
        "hgnc": "HGNC:18398",
        "name": "SNF2 related chromatin remodeling ATPase with DExD box 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smarcad1"
      },
      {
        "slug": "srebf1",
        "symbol": "SREBF1",
        "hgnc": "HGNC:11289",
        "name": "sterol regulatory element binding transcription factor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/srebf1"
      },
      {
        "slug": "aagab",
        "symbol": "AAGAB",
        "hgnc": "HGNC:25662",
        "name": "alpha and gamma adaptin binding protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aagab"
      },
      {
        "slug": "col14a1",
        "symbol": "COL14A1",
        "hgnc": "HGNC:2191",
        "name": "collagen type XIV alpha 1 chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col14a1"
      },
      {
        "slug": "gsn",
        "symbol": "GSN",
        "hgnc": "HGNC:4620",
        "name": "gelsolin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gsn"
      },
      {
        "slug": "pi4ka",
        "symbol": "PI4KA",
        "hgnc": "HGNC:8983",
        "name": "phosphatidylinositol 4-kinase alpha",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pi4ka"
      },
      {
        "slug": "ttc7a",
        "symbol": "TTC7A",
        "hgnc": "HGNC:19750",
        "name": "tetratricopeptide repeat domain 7A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc7a"
      },
      {
        "slug": "ap1s3",
        "symbol": "AP1S3",
        "hgnc": "HGNC:18971",
        "name": "adaptor related protein complex 1 subunit sigma 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1s3"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "hgnc": "HGNC:11231",
        "name": "atlastin GTPase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl1"
      },
      {
        "slug": "cd151",
        "symbol": "CD151",
        "hgnc": "HGNC:1630",
        "name": "CD151 molecule (Raph blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd151"
      },
      {
        "slug": "dnajc21",
        "symbol": "DNAJC21",
        "hgnc": "HGNC:27030",
        "name": "DnaJ heat shock protein family (Hsp40) member C21",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc21"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "jup",
        "symbol": "JUP",
        "hgnc": "HGNC:6207",
        "name": "junction plakoglobin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jup"
      },
      {
        "slug": "krt86",
        "symbol": "KRT86",
        "hgnc": "HGNC:6463",
        "name": "keratin 86",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt86"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "pomp",
        "symbol": "POMP",
        "hgnc": "HGNC:20330",
        "name": "proteasome maturation protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomp"
      },
      {
        "slug": "rspo1",
        "symbol": "RSPO1",
        "hgnc": "HGNC:21679",
        "name": "R-spondin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo1"
      },
      {
        "slug": "trpv3",
        "symbol": "TRPV3",
        "hgnc": "HGNC:18084",
        "name": "transient receptor potential cation channel subfamily V member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv3"
      }
    ]
  }
}