{
  "url": "https://dantelabs.com/traits/kernicterus",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "kernicterus",
    "id": "HP:0001343",
    "name": "Kernicterus",
    "definition": "Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-brain-morphology",
        "name": "Abnormal shape of brain",
        "url": "https://dantelabs.com/traits/abnormal-brain-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ugt1a1",
        "symbol": "UGT1A1",
        "hgnc": "HGNC:12530",
        "name": "UDP glucuronosyltransferase family 1 member A1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ugt1a1"
      },
      {
        "slug": "rhd",
        "symbol": "RHD",
        "hgnc": "HGNC:10009",
        "name": "Rh blood group D antigen",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhd"
      }
    ]
  }
}