{
  "url": "https://dantelabs.com/traits/increased-connective-tissue",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-connective-tissue",
    "id": "HP:0009025",
    "name": "Increased connective tissue",
    "definition": "The presence of an abnormally increased amount of connective tissue.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-connective-tissue",
        "name": "Abnormality of connective tissue",
        "url": "https://dantelabs.com/traits/abnormality-of-connective-tissue"
      }
    ],
    "narrower": [
      {
        "slug": "increased-adipose-tissue",
        "name": "Increased adipose tissue",
        "genes": 6,
        "url": "https://dantelabs.com/traits/increased-adipose-tissue"
      }
    ],
    "genes": [
      {
        "slug": "acta1",
        "symbol": "ACTA1",
        "hgnc": "HGNC:129",
        "name": "actin alpha 1, skeletal muscle",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/acta1"
      },
      {
        "slug": "pskh1",
        "symbol": "PSKH1",
        "hgnc": "HGNC:9529",
        "name": "protein serine kinase H1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pskh1"
      },
      {
        "slug": "lama2",
        "symbol": "LAMA2",
        "hgnc": "HGNC:6482",
        "name": "laminin subunit alpha 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama2"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "klhl40",
        "symbol": "KLHL40",
        "hgnc": "HGNC:30372",
        "name": "kelch like family member 40",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl40"
      },
      {
        "slug": "klhl41",
        "symbol": "KLHL41",
        "hgnc": "HGNC:16905",
        "name": "kelch like family member 41",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl41"
      },
      {
        "slug": "lmod3",
        "symbol": "LMOD3",
        "hgnc": "HGNC:6649",
        "name": "leiomodin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmod3"
      },
      {
        "slug": "neb",
        "symbol": "NEB",
        "hgnc": "HGNC:7720",
        "name": "nebulin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neb"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "nefl",
        "symbol": "NEFL",
        "hgnc": "HGNC:7739",
        "name": "neurofilament light chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefl"
      },
      {
        "slug": "tnxb",
        "symbol": "TNXB",
        "hgnc": "HGNC:11976",
        "name": "tenascin XB",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnxb"
      },
      {
        "slug": "uros",
        "symbol": "UROS",
        "hgnc": "HGNC:12592",
        "name": "uroporphyrinogen III synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uros"
      },
      {
        "slug": "ano5",
        "symbol": "ANO5",
        "hgnc": "HGNC:27337",
        "name": "anoctamin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano5"
      },
      {
        "slug": "dysf",
        "symbol": "DYSF",
        "hgnc": "HGNC:3097",
        "name": "dysferlin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dysf"
      },
      {
        "slug": "lims2",
        "symbol": "LIMS2",
        "hgnc": "HGNC:16084",
        "name": "LIM zinc finger domain containing 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lims2"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "tcap",
        "symbol": "TCAP",
        "hgnc": "HGNC:11610",
        "name": "titin-cap",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcap"
      }
    ]
  }
}