{
  "url": "https://dantelabs.com/traits/hypophosphatemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypophosphatemia",
    "id": "HP:0002148",
    "name": "Low blood phosphate level",
    "label": "Hypophosphatemia",
    "definition": "The concentration of phosphate ion in the blood circulation is below the lower limit of normal.",
    "synonyms": [
      "Decreased phosphate ion concentration",
      "Decreased phosphate ion level",
      "Decreased phosphate ion level in blood",
      "Hypophosphataemia",
      "Reduced phosphate ion concentration",
      "Reduced phosphate ion level",
      "Reduced phosphate ion level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-phosphate-ion-concentration",
        "name": "Abnormal circulating phosphate ion concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-phosphate-ion-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "renal-hypophosphatemia",
        "name": "Renal hypophosphatemia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/renal-hypophosphatemia"
      }
    ],
    "genes": [
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "cyp27b1",
        "symbol": "CYP27B1",
        "hgnc": "HGNC:2606",
        "name": "cytochrome P450 family 27 subfamily B member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp27b1"
      },
      {
        "slug": "cyp2r1",
        "symbol": "CYP2R1",
        "hgnc": "HGNC:20580",
        "name": "cytochrome P450 family 2 subfamily R member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp2r1"
      },
      {
        "slug": "hmgcs2",
        "symbol": "HMGCS2",
        "hgnc": "HGNC:5008",
        "name": "3-hydroxy-3-methylglutaryl-CoA synthase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmgcs2"
      },
      {
        "slug": "hnf4a",
        "symbol": "HNF4A",
        "hgnc": "HGNC:5024",
        "name": "hepatocyte nuclear factor 4 alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf4a"
      },
      {
        "slug": "phex",
        "symbol": "PHEX",
        "hgnc": "HGNC:8918",
        "name": "phosphate regulating endopeptidase X-linked",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/phex"
      },
      {
        "slug": "slc34a1",
        "symbol": "SLC34A1",
        "hgnc": "HGNC:11019",
        "name": "solute carrier family 34 member 1",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/slc34a1"
      },
      {
        "slug": "slc34a3",
        "symbol": "SLC34A3",
        "hgnc": "HGNC:20305",
        "name": "solute carrier family 34 member 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc34a3"
      },
      {
        "slug": "cacna1s",
        "symbol": "CACNA1S",
        "hgnc": "HGNC:1397",
        "name": "calcium voltage-gated channel subunit alpha1 S",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1s"
      },
      {
        "slug": "cdc73",
        "symbol": "CDC73",
        "hgnc": "HGNC:16783",
        "name": "cell division cycle 73",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/cdc73"
      },
      {
        "slug": "fgf23",
        "symbol": "FGF23",
        "hgnc": "HGNC:3680",
        "name": "fibroblast growth factor 23",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgf23"
      },
      {
        "slug": "gabra3",
        "symbol": "GABRA3",
        "hgnc": "HGNC:4077",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra3"
      },
      {
        "slug": "gcm2",
        "symbol": "GCM2",
        "hgnc": "HGNC:4198",
        "name": "GCM transcription factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcm2"
      },
      {
        "slug": "inppl1",
        "symbol": "INPPL1",
        "hgnc": "HGNC:6080",
        "name": "inositol polyphosphate phosphatase like 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inppl1"
      },
      {
        "slug": "kcnj18",
        "symbol": "KCNJ18",
        "hgnc": "HGNC:39080",
        "name": "potassium inwardly rectifying channel subfamily J member 18",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj18"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "slc2a2",
        "symbol": "SLC2A2",
        "hgnc": "HGNC:11006",
        "name": "solute carrier family 2 member 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc2a2"
      },
      {
        "slug": "vdr",
        "symbol": "VDR",
        "hgnc": "HGNC:12679",
        "name": "vitamin D receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vdr"
      },
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "ehhadh",
        "symbol": "EHHADH",
        "hgnc": "HGNC:3247",
        "name": "enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ehhadh"
      },
      {
        "slug": "gatm",
        "symbol": "GATM",
        "hgnc": "HGNC:4175",
        "name": "glycine amidinotransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gatm"
      },
      {
        "slug": "ndufaf6",
        "symbol": "NDUFAF6",
        "hgnc": "HGNC:28625",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 6",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf6"
      },
      {
        "slug": "ocrl",
        "symbol": "OCRL",
        "hgnc": "HGNC:8108",
        "name": "OCRL inositol polyphosphate-5-phosphatase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ocrl"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pth1r"
      },
      {
        "slug": "aldob",
        "symbol": "ALDOB",
        "hgnc": "HGNC:417",
        "name": "aldolase, fructose-bisphosphate B",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aldob"
      },
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "fbxo22",
        "symbol": "FBXO22",
        "hgnc": "HGNC:13593",
        "name": "F-box protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo22"
      },
      {
        "slug": "ostm1",
        "symbol": "OSTM1",
        "hgnc": "HGNC:21652",
        "name": "osteoclastogenesis associated transmembrane protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ostm1"
      },
      {
        "slug": "polrmt",
        "symbol": "POLRMT",
        "hgnc": "HGNC:9200",
        "name": "RNA polymerase mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polrmt"
      },
      {
        "slug": "snx10",
        "symbol": "SNX10",
        "hgnc": "HGNC:14974",
        "name": "sorting nexin 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snx10"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "tnfsf11",
        "symbol": "TNFSF11",
        "hgnc": "HGNC:11926",
        "name": "TNF superfamily member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf11"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "ap2s1",
        "symbol": "AP2S1",
        "hgnc": "HGNC:565",
        "name": "adaptor related protein complex 2 subunit sigma 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap2s1"
      },
      {
        "slug": "casr",
        "symbol": "CASR",
        "hgnc": "HGNC:1514",
        "name": "calcium sensing receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casr"
      },
      {
        "slug": "clcn5",
        "symbol": "CLCN5",
        "hgnc": "HGNC:2023",
        "name": "Cl-/H+ antiporter 5",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/clcn5"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "cyp3a4",
        "symbol": "CYP3A4",
        "hgnc": "HGNC:2637",
        "name": "cytochrome P450 family 3 subfamily A member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp3a4"
      },
      {
        "slug": "dmp1",
        "symbol": "DMP1",
        "hgnc": "HGNC:2932",
        "name": "dentin matrix acidic phosphoprotein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmp1"
      },
      {
        "slug": "fam20c",
        "symbol": "FAM20C",
        "hgnc": "HGNC:22140",
        "name": "FAM20C golgi associated secretory pathway kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam20c"
      },
      {
        "slug": "nherf1",
        "symbol": "NHERF1",
        "hgnc": "HGNC:11075",
        "name": "NHERF family PDZ scaffold protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nherf1"
      }
    ]
  }
}