{
  "url": "https://dantelabs.com/traits/generalized-hyperkeratosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "generalized-hyperkeratosis",
    "id": "HP:0005595",
    "name": "Generalized hyperkeratosis",
    "synonyms": [
      "Generalised hyperkeratosis",
      "Hyperkeratosis, generalised",
      "Hyperkeratosis, generalized"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gjb3",
        "symbol": "GJB3",
        "hgnc": "HGNC:4285",
        "name": "gap junction protein beta 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb3"
      },
      {
        "slug": "krt10",
        "symbol": "KRT10",
        "hgnc": "HGNC:6413",
        "name": "keratin 10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt10"
      },
      {
        "slug": "fuca1",
        "symbol": "FUCA1",
        "hgnc": "HGNC:4006",
        "name": "alpha-L-fucosidase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fuca1"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      }
    ]
  }
}