{
  "url": "https://dantelabs.com/traits/functional-motor-deficit",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "functional-motor-deficit",
    "id": "HP:0004302",
    "name": "Functional motor deficit",
    "synonyms": [
      "Functional motor problems"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-muscle-physiology",
        "name": "Issue with muscle function",
        "url": "https://dantelabs.com/traits/abnormal-muscle-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "frequent-falls",
        "name": "Frequent falls",
        "genes": 149,
        "url": "https://dantelabs.com/traits/frequent-falls"
      },
      {
        "slug": "easy-fatigability",
        "name": "Tired easily",
        "genes": 98,
        "url": "https://dantelabs.com/traits/easy-fatigability"
      },
      {
        "slug": "difficulty-climbing-stairs",
        "name": "Difficulty walking up stairs",
        "genes": 75,
        "url": "https://dantelabs.com/traits/difficulty-climbing-stairs"
      },
      {
        "slug": "difficulty-running",
        "name": "Difficulty running",
        "genes": 58,
        "url": "https://dantelabs.com/traits/difficulty-running"
      },
      {
        "slug": "difficulty-standing",
        "name": "Difficulty in standing",
        "genes": 23,
        "url": "https://dantelabs.com/traits/difficulty-standing"
      },
      {
        "slug": "difficulty-descending-stairs",
        "name": "Difficulty descending stairs",
        "genes": 1,
        "url": "https://dantelabs.com/traits/difficulty-descending-stairs"
      }
    ],
    "genes": [
      {
        "slug": "asah1",
        "symbol": "ASAH1",
        "hgnc": "HGNC:735",
        "name": "N-acylsphingosine amidohydrolase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asah1"
      },
      {
        "slug": "aspa",
        "symbol": "ASPA",
        "hgnc": "HGNC:756",
        "name": "aspartoacylase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aspa"
      },
      {
        "slug": "cdkl5",
        "symbol": "CDKL5",
        "hgnc": "HGNC:11411",
        "name": "cyclin dependent kinase like 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkl5"
      },
      {
        "slug": "gabbr2",
        "symbol": "GABBR2",
        "hgnc": "HGNC:4507",
        "name": "gamma-aminobutyric acid type B receptor subunit 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabbr2"
      },
      {
        "slug": "galc",
        "symbol": "GALC",
        "hgnc": "HGNC:4115",
        "name": "galactosylceramidase",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/galc"
      },
      {
        "slug": "kcnq2",
        "symbol": "KCNQ2",
        "hgnc": "HGNC:6296",
        "name": "potassium voltage-gated channel subfamily Q member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq2"
      },
      {
        "slug": "kcnt1",
        "symbol": "KCNT1",
        "hgnc": "HGNC:18865",
        "name": "potassium sodium-activated channel subfamily T member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnt1"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "ntng1",
        "symbol": "NTNG1",
        "hgnc": "HGNC:23319",
        "name": "netrin G1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntng1"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "plcb1",
        "symbol": "PLCB1",
        "hgnc": "HGNC:15917",
        "name": "phospholipase C beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcb1"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "scn2a",
        "symbol": "SCN2A",
        "hgnc": "HGNC:10588",
        "name": "sodium voltage-gated channel alpha subunit 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn2a"
      },
      {
        "slug": "sh3tc2",
        "symbol": "SH3TC2",
        "hgnc": "HGNC:29427",
        "name": "SH3 domain and tetratricopeptide repeats 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh3tc2"
      },
      {
        "slug": "slc12a5",
        "symbol": "SLC12A5",
        "hgnc": "HGNC:13818",
        "name": "solute carrier family 12 member 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a5"
      },
      {
        "slug": "slc25a22",
        "symbol": "SLC25A22",
        "hgnc": "HGNC:19954",
        "name": "solute carrier family 25 member 22",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a22"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "hgnc": "HGNC:61",
        "name": "ATP binding cassette subfamily D member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcd1"
      },
      {
        "slug": "brcc3",
        "symbol": "BRCC3",
        "hgnc": "HGNC:24185",
        "name": "BRCA1/BRCA2-containing complex subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brcc3"
      },
      {
        "slug": "ccdc88c",
        "symbol": "CCDC88C",
        "hgnc": "HGNC:19967",
        "name": "coiled-coil and HOOK domain protein 88C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc88c"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "ercc8",
        "symbol": "ERCC8",
        "hgnc": "HGNC:3439",
        "name": "ERCC excision repair 8, CSA ubiquitin ligase complex subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc8"
      },
      {
        "slug": "ext1",
        "symbol": "EXT1",
        "hgnc": "HGNC:3512",
        "name": "exostosin glycosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext1"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      },
      {
        "slug": "grid2",
        "symbol": "GRID2",
        "hgnc": "HGNC:4576",
        "name": "glutamate ionotropic receptor delta type subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grid2"
      },
      {
        "slug": "grm1",
        "symbol": "GRM1",
        "hgnc": "HGNC:4593",
        "name": "glutamate metabotropic receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grm1"
      },
      {
        "slug": "mff",
        "symbol": "MFF",
        "hgnc": "HGNC:24858",
        "name": "mitochondrial fission factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mff"
      },
      {
        "slug": "morc2",
        "symbol": "MORC2",
        "hgnc": "HGNC:23573",
        "name": "MORC family CW-type zinc finger 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/morc2"
      },
      {
        "slug": "oca2",
        "symbol": "OCA2",
        "hgnc": "HGNC:8101",
        "name": "OCA2 melanosomal transmembrane protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oca2"
      },
      {
        "slug": "plp1",
        "symbol": "PLP1",
        "hgnc": "HGNC:9086",
        "name": "proteolipid protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plp1"
      },
      {
        "slug": "spast",
        "symbol": "SPAST",
        "hgnc": "HGNC:11233",
        "name": "spastin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spast"
      },
      {
        "slug": "ube3a",
        "symbol": "UBE3A",
        "hgnc": "HGNC:12496",
        "name": "ubiquitin protein ligase E3A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube3a"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "akt3",
        "symbol": "AKT3",
        "hgnc": "HGNC:393",
        "name": "AKT serine/threonine kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt3"
      },
      {
        "slug": "alad",
        "symbol": "ALAD",
        "hgnc": "HGNC:395",
        "name": "aminolevulinate dehydratase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alad"
      },
      {
        "slug": "bap1",
        "symbol": "BAP1",
        "hgnc": "HGNC:950",
        "name": "BRCA1 associated deubiquitinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bap1"
      },
      {
        "slug": "cox7b",
        "symbol": "COX7B",
        "hgnc": "HGNC:2291",
        "name": "cytochrome c oxidase subunit 7B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox7b"
      },
      {
        "slug": "dlat",
        "symbol": "DLAT",
        "hgnc": "HGNC:2896",
        "name": "dihydrolipoamide S-acetyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlat"
      },
      {
        "slug": "hccs",
        "symbol": "HCCS",
        "hgnc": "HGNC:4837",
        "name": "holocytochrome c synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hccs"
      },
      {
        "slug": "jph3",
        "symbol": "JPH3",
        "hgnc": "HGNC:14203",
        "name": "junctophilin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph3"
      },
      {
        "slug": "lmnb1",
        "symbol": "LMNB1",
        "hgnc": "HGNC:6637",
        "name": "lamin B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb1"
      },
      {
        "slug": "mtor",
        "symbol": "MTOR",
        "hgnc": "HGNC:3942",
        "name": "mechanistic target of rapamycin kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtor"
      },
      {
        "slug": "ndufb11",
        "symbol": "NDUFB11",
        "hgnc": "HGNC:20372",
        "name": "NADH:ubiquinone oxidoreductase subunit B11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb11"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "pdgfb",
        "symbol": "PDGFB",
        "hgnc": "HGNC:8800",
        "name": "platelet derived growth factor subunit B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfb"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "selenoi",
        "symbol": "SELENOI",
        "hgnc": "HGNC:29361",
        "name": "selenoprotein I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/selenoi"
      },
      {
        "slug": "slc19a3",
        "symbol": "SLC19A3",
        "hgnc": "HGNC:16266",
        "name": "solute carrier family 19 member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc19a3"
      },
      {
        "slug": "smarcb1",
        "symbol": "SMARCB1",
        "hgnc": "HGNC:11103",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcb1"
      },
      {
        "slug": "smarce1",
        "symbol": "SMARCE1",
        "hgnc": "HGNC:11109",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit E1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarce1"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "stx11",
        "symbol": "STX11",
        "hgnc": "HGNC:11429",
        "name": "syntaxin 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx11"
      },
      {
        "slug": "stxbp2",
        "symbol": "STXBP2",
        "hgnc": "HGNC:11445",
        "name": "syntaxin binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stxbp2"
      },
      {
        "slug": "sufu",
        "symbol": "SUFU",
        "hgnc": "HGNC:16466",
        "name": "SUFU negative regulator of hedgehog signaling",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sufu"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "ticam1",
        "symbol": "TICAM1",
        "hgnc": "HGNC:18348",
        "name": "TIR domain containing adaptor molecule 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ticam1"
      },
      {
        "slug": "tlr3",
        "symbol": "TLR3",
        "hgnc": "HGNC:11849",
        "name": "toll like receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr3"
      },
      {
        "slug": "traf3",
        "symbol": "TRAF3",
        "hgnc": "HGNC:12033",
        "name": "TNF receptor associated factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3"
      },
      {
        "slug": "traf7",
        "symbol": "TRAF7",
        "hgnc": "HGNC:20456",
        "name": "TNF receptor associated factor 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf7"
      },
      {
        "slug": "unc13d",
        "symbol": "UNC13D",
        "hgnc": "HGNC:23147",
        "name": "unc-13 homolog D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13d"
      },
      {
        "slug": "unc93b1",
        "symbol": "UNC93B1",
        "hgnc": "HGNC:13481",
        "name": "unc-93B1 regulator of TLR signaling",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc93b1"
      },
      {
        "slug": "vps13a",
        "symbol": "VPS13A",
        "hgnc": "HGNC:1908",
        "name": "vacuolar protein sorting 13 homolog A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13a"
      }
    ]
  }
}