{
  "url": "https://dantelabs.com/traits/frontal-polymicrogyria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "frontal-polymicrogyria",
    "id": "HP:0006821",
    "name": "Frontal polymicrogyria",
    "definition": "A type of polymicrogyria with a gradient of severity (anterior more severe than posterior) extending from frontal poles posteriorly to precentral gyrus and inferiorly to frontal operculum.",
    "synonyms": [
      "Polymicrogyria, anterior to posterior gradient"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "polymicrogyria",
        "name": "More grooves in brain",
        "url": "https://dantelabs.com/traits/polymicrogyria"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "adgrg1",
        "symbol": "ADGRG1",
        "hgnc": "HGNC:4512",
        "name": "adhesion G protein-coupled receptor G1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adgrg1"
      },
      {
        "slug": "ahi1",
        "symbol": "AHI1",
        "hgnc": "HGNC:21575",
        "name": "Abelson helper integration site 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahi1"
      },
      {
        "slug": "arhgef9",
        "symbol": "ARHGEF9",
        "hgnc": "HGNC:14561",
        "name": "Cdc42 guanine nucleotide exchange factor 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgef9"
      },
      {
        "slug": "trmt10c",
        "symbol": "TRMT10C",
        "hgnc": "HGNC:26022",
        "name": "tRNA methyltransferase 10C, mitochondrial RNase P subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10c"
      },
      {
        "slug": "tubb3",
        "symbol": "TUBB3",
        "hgnc": "HGNC:20772",
        "name": "tubulin beta 3 class III",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb3"
      },
      {
        "slug": "dync1h1",
        "symbol": "DYNC1H1",
        "hgnc": "HGNC:2961",
        "name": "dynein cytoplasmic 1 heavy chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync1h1"
      },
      {
        "slug": "ppfibp1",
        "symbol": "PPFIBP1",
        "hgnc": "HGNC:9249",
        "name": "PPFIB scaffold protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppfibp1"
      }
    ]
  }
}