{
  "url": "https://dantelabs.com/traits/cortical-irregularity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cortical-irregularity",
    "id": "HP:0005731",
    "name": "Cortical irregularity",
    "definition": "An abnormal irregularity of cortical bone.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cortical-bone-morphology",
        "name": "Abnormal cortical bone morphology",
        "url": "https://dantelabs.com/traits/abnormal-cortical-bone-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "hgnc": "HGNC:2197",
        "name": "collagen type I alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col1a1"
      },
      {
        "slug": "sh3pxd2b",
        "symbol": "SH3PXD2B",
        "hgnc": "HGNC:29242",
        "name": "SH3 and PX domains 2B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh3pxd2b"
      }
    ]
  }
}