{
  "url": "https://dantelabs.com/traits/claw-hand-deformity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "claw-hand-deformity",
    "id": "HP:0034337",
    "name": "Claw hand deformity",
    "definition": "An abnormality of the hand characterized by metacarpophalangeal (MCP) hyperextension and proximal interphalangeal (PIP) and distal interphalangeal (DIP) flexion. The position of the affected hand is said to resemble a claw.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "joint-contracture-of-the-hand",
        "name": "Joint contracture of the hand",
        "url": "https://dantelabs.com/traits/joint-contracture-of-the-hand"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gnptab",
        "symbol": "GNPTAB",
        "hgnc": "HGNC:29670",
        "name": "N-acetylglucosamine-1-phosphate transferase subunits alpha and beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnptab"
      },
      {
        "slug": "gnptg",
        "symbol": "GNPTG",
        "hgnc": "HGNC:23026",
        "name": "N-acetylglucosamine-1-phosphate transferase subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnptg"
      },
      {
        "slug": "sptan1",
        "symbol": "SPTAN1",
        "hgnc": "HGNC:11273",
        "name": "spectrin alpha, non-erythrocytic 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptan1"
      },
      {
        "slug": "cog8",
        "symbol": "COG8",
        "hgnc": "HGNC:18623",
        "name": "component of oligomeric golgi complex 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog8"
      },
      {
        "slug": "hspb1",
        "symbol": "HSPB1",
        "hgnc": "HGNC:5246",
        "name": "heat shock protein family B (small) member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspb1"
      },
      {
        "slug": "ndrg1",
        "symbol": "NDRG1",
        "hgnc": "HGNC:7679",
        "name": "N-myc downstream regulated 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndrg1"
      },
      {
        "slug": "pdxk",
        "symbol": "PDXK",
        "hgnc": "HGNC:8819",
        "name": "pyridoxal kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdxk"
      },
      {
        "slug": "sigmar1",
        "symbol": "SIGMAR1",
        "hgnc": "HGNC:8157",
        "name": "sigma receptor chaperone 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sigmar1"
      },
      {
        "slug": "hk1",
        "symbol": "HK1",
        "hgnc": "HGNC:4922",
        "name": "hexokinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hk1"
      },
      {
        "slug": "inf2",
        "symbol": "INF2",
        "hgnc": "HGNC:23791",
        "name": "inverted formin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inf2"
      }
    ]
  }
}