{
  "url": "https://dantelabs.com/traits/bronchoconstriction",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "bronchoconstriction",
    "id": "HP:4000007",
    "name": "Bronchoconstriction",
    "definition": "Tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath.",
    "synonyms": [
      "Bronchial constriction",
      "Bronchospasm",
      "Constriction of the bronchi"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-bronchus-physiology",
        "name": "Abnormal bronchus physiology",
        "url": "https://dantelabs.com/traits/abnormal-bronchus-physiology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "galns",
        "symbol": "GALNS",
        "hgnc": "HGNC:4122",
        "name": "galactosamine (N-acetyl)-6-sulfatase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galns"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "hgnc": "HGNC:20",
        "name": "alanyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars1"
      },
      {
        "slug": "cars1",
        "symbol": "CARS1",
        "hgnc": "HGNC:1493",
        "name": "cysteinyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cars1"
      },
      {
        "slug": "dbr1",
        "symbol": "DBR1",
        "hgnc": "HGNC:15594",
        "name": "debranching RNA lariats 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dbr1"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "ercc3",
        "symbol": "ERCC3",
        "hgnc": "HGNC:3435",
        "name": "ERCC excision repair 3, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc3"
      },
      {
        "slug": "gtf2e2",
        "symbol": "GTF2E2",
        "hgnc": "HGNC:4651",
        "name": "general transcription factor IIE subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2e2"
      },
      {
        "slug": "gtf2h5",
        "symbol": "GTF2H5",
        "hgnc": "HGNC:21157",
        "name": "general transcription factor IIH subunit 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2h5"
      },
      {
        "slug": "mplkip",
        "symbol": "MPLKIP",
        "hgnc": "HGNC:16002",
        "name": "M-phase specific PLK1 interacting protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mplkip"
      },
      {
        "slug": "rnf113a",
        "symbol": "RNF113A",
        "hgnc": "HGNC:12974",
        "name": "ring finger protein 113A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf113a"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "tars1",
        "symbol": "TARS1",
        "hgnc": "HGNC:11572",
        "name": "threonyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tars1"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "acan",
        "symbol": "ACAN",
        "hgnc": "HGNC:319",
        "name": "aggrecan",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acan"
      },
      {
        "slug": "alox5",
        "symbol": "ALOX5",
        "hgnc": "HGNC:435",
        "name": "arachidonate 5-lipoxygenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alox5"
      },
      {
        "slug": "ccl11",
        "symbol": "CCL11",
        "hgnc": "HGNC:10610",
        "name": "C-C motif chemokine ligand 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccl11"
      },
      {
        "slug": "hla-g",
        "symbol": "HLA-G",
        "hgnc": "HGNC:4964",
        "name": "major histocompatibility complex, class I, G",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-g"
      },
      {
        "slug": "hnmt",
        "symbol": "HNMT",
        "hgnc": "HGNC:5028",
        "name": "histamine N-methyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnmt"
      },
      {
        "slug": "il13",
        "symbol": "IL13",
        "hgnc": "HGNC:5973",
        "name": "interleukin 13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il13"
      },
      {
        "slug": "muc7",
        "symbol": "MUC7",
        "hgnc": "HGNC:7518",
        "name": "mucin 7, secreted",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/muc7"
      },
      {
        "slug": "ptger2",
        "symbol": "PTGER2",
        "hgnc": "HGNC:9594",
        "name": "prostaglandin E receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptger2"
      },
      {
        "slug": "scgb3a2",
        "symbol": "SCGB3A2",
        "hgnc": "HGNC:18391",
        "name": "secretoglobin family 3A member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scgb3a2"
      },
      {
        "slug": "tbx21",
        "symbol": "TBX21",
        "hgnc": "HGNC:11599",
        "name": "T-box transcription factor 21",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx21"
      },
      {
        "slug": "tnf",
        "symbol": "TNF",
        "hgnc": "HGNC:11892",
        "name": "tumor necrosis factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnf"
      },
      {
        "slug": "tspyl1",
        "symbol": "TSPYL1",
        "hgnc": "HGNC:12382",
        "name": "TSPY like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tspyl1"
      }
    ]
  }
}