{
  "url": "https://dantelabs.com/traits/anotia",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "anotia",
    "id": "HP:0009892",
    "name": "Absent ear",
    "label": "Anotia",
    "definition": "Complete absence of any auricular structures.",
    "synonyms": [
      "Absent ears"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-external-ear",
        "name": "Absent/small external ear",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-external-ear"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cdc45",
        "symbol": "CDC45",
        "hgnc": "HGNC:1739",
        "name": "cell division cycle 45",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc45"
      },
      {
        "slug": "cdc6",
        "symbol": "CDC6",
        "hgnc": "HGNC:1744",
        "name": "cell division cycle 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc6"
      },
      {
        "slug": "cdt1",
        "symbol": "CDT1",
        "hgnc": "HGNC:24576",
        "name": "chromatin licensing and DNA replication factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdt1"
      },
      {
        "slug": "gmnn",
        "symbol": "GMNN",
        "hgnc": "HGNC:17493",
        "name": "geminin DNA replication inhibitor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gmnn"
      },
      {
        "slug": "orc1",
        "symbol": "ORC1",
        "hgnc": "HGNC:8487",
        "name": "origin recognition complex subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orc1"
      },
      {
        "slug": "orc4",
        "symbol": "ORC4",
        "hgnc": "HGNC:8490",
        "name": "origin recognition complex subunit 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orc4"
      },
      {
        "slug": "orc6",
        "symbol": "ORC6",
        "hgnc": "HGNC:17151",
        "name": "origin recognition complex subunit 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orc6"
      },
      {
        "slug": "fancl",
        "symbol": "FANCL",
        "hgnc": "HGNC:20748",
        "name": "FA complementation group L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancl"
      },
      {
        "slug": "hoxa2",
        "symbol": "HOXA2",
        "hgnc": "HGNC:5103",
        "name": "homeobox A2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxa2"
      },
      {
        "slug": "polr1a",
        "symbol": "POLR1A",
        "hgnc": "HGNC:17264",
        "name": "RNA polymerase I subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1a"
      },
      {
        "slug": "fancb",
        "symbol": "FANCB",
        "hgnc": "HGNC:3583",
        "name": "FA complementation group B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancb"
      },
      {
        "slug": "polr1d",
        "symbol": "POLR1D",
        "hgnc": "HGNC:20422",
        "name": "RNA polymerase I and III subunit D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1d"
      },
      {
        "slug": "ddx3x",
        "symbol": "DDX3X",
        "hgnc": "HGNC:2745",
        "name": "DEAD-box helicase 3 X-linked",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddx3x"
      },
      {
        "slug": "sf3b2",
        "symbol": "SF3B2",
        "hgnc": "HGNC:10769",
        "name": "splicing factor 3b subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b2"
      }
    ]
  }
}