{
  "url": "https://dantelabs.com/traits/airway-hyperresponsiveness",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "airway-hyperresponsiveness",
    "id": "HP:0032933",
    "name": "Airway hyperresponsiveness",
    "definition": "An increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-respiratory-system-physiology",
        "name": "Functional respiratory abnormality",
        "url": "https://dantelabs.com/traits/abnormal-respiratory-system-physiology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "alox5",
        "symbol": "ALOX5",
        "hgnc": "HGNC:435",
        "name": "arachidonate 5-lipoxygenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alox5"
      },
      {
        "slug": "ccl11",
        "symbol": "CCL11",
        "hgnc": "HGNC:10610",
        "name": "C-C motif chemokine ligand 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccl11"
      },
      {
        "slug": "hla-g",
        "symbol": "HLA-G",
        "hgnc": "HGNC:4964",
        "name": "major histocompatibility complex, class I, G",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-g"
      },
      {
        "slug": "hnmt",
        "symbol": "HNMT",
        "hgnc": "HGNC:5028",
        "name": "histamine N-methyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnmt"
      },
      {
        "slug": "il13",
        "symbol": "IL13",
        "hgnc": "HGNC:5973",
        "name": "interleukin 13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il13"
      },
      {
        "slug": "muc7",
        "symbol": "MUC7",
        "hgnc": "HGNC:7518",
        "name": "mucin 7, secreted",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/muc7"
      },
      {
        "slug": "scgb3a2",
        "symbol": "SCGB3A2",
        "hgnc": "HGNC:18391",
        "name": "secretoglobin family 3A member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scgb3a2"
      },
      {
        "slug": "tnf",
        "symbol": "TNF",
        "hgnc": "HGNC:11892",
        "name": "tumor necrosis factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnf"
      }
    ]
  }
}