{
  "url": "https://dantelabs.com/traits/acromelia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acromelia",
    "id": "HP:0010884",
    "name": "Acromelia",
    "definition": "Shortening of the extremities affecting primarily the distal parts of the limbs (hands and feet) in relation to the other segments of the limbs.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-extremities",
        "name": "Absent/small extremities",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-extremities"
      }
    ],
    "narrower": [
      {
        "slug": "acromelia-of-the-lower-limbs",
        "name": "Acromelia of the lower limbs",
        "genes": 3,
        "url": "https://dantelabs.com/traits/acromelia-of-the-lower-limbs"
      }
    ],
    "genes": [
      {
        "slug": "tbck",
        "symbol": "TBCK",
        "hgnc": "HGNC:28261",
        "name": "TBC1 domain containing kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbck"
      },
      {
        "slug": "ctsk",
        "symbol": "CTSK",
        "hgnc": "HGNC:2536",
        "name": "cathepsin K",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsk"
      },
      {
        "slug": "hyal2",
        "symbol": "HYAL2",
        "hgnc": "HGNC:5321",
        "name": "hyaluronidase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyal2"
      }
    ]
  }
}